Skip to main content
Explore URMC

URMC Logo

menu

Clive S. Zent, M.D.

Cancer

Clinical Interests

Hematologic Oncology; Lymphoma, Chronic Lymphocytic Leukemia

Contact Information

Phone Numbers

Appointment: (585) 275-5823

Fax: (585) 273-1042

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

I chose this specialty because I have always had an interest in diseases of the blood. My patients can be confident knowing I provide optimal individual patient care based on precision diagnosis and targeted therapy. Although I treat many types of blood diseases, my area of expertise is chronic lymphocytic leukemia.

Conditions I Treat:

- Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL)
- Hairy cell leukemia
- Prolymphocytic leukemia
- Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia)
- Large granular lymphocytic leukemia

Professional Background

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program.

Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.

Research

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program.

Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.

Credentials

Faculty Appointments

Specialties

  • Hematology - American Board of Internal Medicine
  • Internal Medicine - American Board of Internal Medicine

Education

1983
MBBCh | University of the Witwatersrand

1987-1991
MMed | University of Cape Town
Internal Medicine

Post-doctoral Training & Residency

7/1/1996 - 6/30/1997
Residency in Internal Medicine at University of Arkansas College of Medicine

7/1/1993 - 6/30/1996
Fellowship in Hematology at University of Chicago Medical Center

7/1/1993 - 6/30/1996
Fellowship in Hematology at University of Chicago Medical Center

7/1/1996 - 6/30/1997
Residency in Internal Medicine at University of Arkansas College of Medicine

VIEW ALL expand_more

Awards

2008
Teacher of the Year in Hematology
Sponsor: Mayo Fellows Association, College of Medicine
Location: Mayo Clinic

1995
Kaminer Fellowship (Travel Award)
Sponsor: University of Chicago
Location: Chicago, IL

1983
Degree with Distinction
Sponsor: University of the Witwatersrand
Location: South Africa

VIEW ALL expand_more

Publications

Journal Articles

9/2017
Helber MJ, Moore JE, Williams AM, Meacham PJ, Rothberg PG, Zent CS. "Ibrutinib therapy for lymphoplasmacytic lymphoma." American journal of hematology.. 2017 Sep 0; 92(9):E542-E544. Epub 2017 Jun 09.

8/2017
Taylor RP, Lindorfer MA, Cook EM, Beurskens FJ, Schuurman J, Parren PWHI, Zent CS, VanDerMeid KR, Burack R, Mizuno M, Paul Morgan B. "Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9." Clinical immunology : the official journal of the Clinical Immunology Society.. 2017 Aug 0; 181:24-28. Epub 2017 May 31.

7/11/2017
Williams AM, Baran AM, Meacham PJ, Feldman MM, Valencia HE, Newsom-Stewart C, Gupta N, Janelsins MC, Barr PM, Zent CS. "Analysis of the risk of infection in patients with chronic lymphocytic leukemia in the era of novel therapies." Leukemia & lymphoma.. 2017 Jul 11; :1-8. Epub 2017 Jul 11.

Books & Chapters

2016
Chapter Title: Chronic lymphocytic leukemia/small lymphocytic lymphoma.
Book Title: ASH-SAP American Society of Hematology Self-Assessment Program
Author List: Zent CS, Call TG
Edited By: Steensma DP, Cuker A, Kempton CL
Published By: American Society of Hematology2016

2010
Chapter Title: Chronic lymphocytic leukemia causing multiple mononeuropathies
Book Title: Companion to Peripheral Neuropathy: Illustrated Cases and New Developments
Author List: Mauermann ML, Zent CS, Low PA
Edited By: Dyck PJ, et.al.
Published By: Saunders/Elsevier2010 in Philadelphia

2010
Chapter Title: Disorders of the Blood
Book Title: Textbook of Medicine
Author List: Zent C and Polliack A
Edited By: Warrel D, Cox T, Firth J
Published By: Oxford2010

VIEW ALL PUBLICATIONS