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Clive S. Zent, M.D.

Cancer

Clinical Interests

Hematologic Oncology Lymphoma, Chronic Lymphocytic Leukemia

Contact Information

Phone Numbers

Administrative: (585) 273-3258

Appointment: (585) 275-5823

Fax: (585) 273-1042

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

I chose this specialty because I have always had an interest in diseases of the blood. My patients can be confident knowing I provide optimal individual patient care based on precision diagnosis and targeted therapy. Although I treat many types of blood diseases, my area of expertise is chronic lymphocytic leukemia. Conditions I Treat: - Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL) - Hairy cell leukemia - Prolymphocytic leukemia - Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia) - Large granular lymphocytic leukemia

Professional Background

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program. Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.

Research

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program. Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.

Credentials

Faculty Appointments

Specialties

  • Hematology - American Board of Internal Medicine
  • Internal Medicine - American Board of Internal Medicine

Education

1987-1991
MMed | University of Cape Town
Internal Medicine

1983
MBBCh | University of the Witwatersrand

Post-doctoral Training & Residency

2/1/1987 - 1/31/1991
Residency in Internal Medicine at Groote Schuur Hospital - University of Cape Town

1/1/1984 - 12/31/1984
Internship in Internal Medicine at University of Witwatersrand

7/1/1993 - 6/30/1996
Fellowship in Internal Medicine: Hematology at University of Chicago Medical Center

7/1/1996 - 6/30/1997
Residency in Internal Medicine at University of Arkansas College of Medicine

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Awards

2008
Teacher of the Year in Hematology
Sponsor: Mayo Fellows Association, College of Medicine
Location: Mayo Clinic

1995
Kaminer Fellowship (Travel Award)
Sponsor: University of Chicago
Location: Chicago, IL

1983
Degree with Distinction
Sponsor: University of the Witwatersrand
Location: South Africa

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Publications

Journal Articles

4/2017
Zent CS, Elliott MR. "Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity." The FEBS journal.. 2017 Apr 0; 284(7):1021-1039. Epub 2016 Nov 29.

2/17/2017
Murphy EJ, Neuberg DS, Rassenti LZ, Hayes G, Redd R, Emson C, Li K, Brown JR, Wierda WG, Turner S, Greaves AW, Zent CS, Byrd JC, McConnel C, Barrientos J, Kay N, Hellerstein MK, Chiorazzi N, Kipps TJ, Rai KR. "Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia." Leukemia.. 2017 Feb 17; Epub 2017 Feb 17.

2/2/2017
Grever MR, Abdel-Wahab O, Andritsos LA, Banerji V, Barrientos J, Blachly JS, Call TG, Catovsky D, Dearden C, Demeter J, Else M, Forconi F, Gozzetti A, Ho AD, Johnston JB, Jones J, Juliusson G, Kraut E, Kreitman RJ, Larratt L, Lauria F, Lozanski G, Montserrat E, Parikh SA, Park JH, Polliack A, Quest GR, Rai KR, Ravandi F, Robak T, Saven A, Seymour JF, Tadmor T, Tallman MS, Tam C, Tiacci E, Troussard X, Zent CS, Zenz T, Zinzani PL, Falini B. "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia." Blood.. 2017 Feb 2; 129(5):553-560. Epub 2016 Nov 30.

Books & Chapters

2010
Chapter Title: Chronic lymphocytic leukemia causing multiple mononeuropathies
Book Title: Companion to Peripheral Neuropathy: Illustrated Cases and New Developments
Author List: Mauermann ML, Zent CS, Low PA
Edited By: Dyck PJ, et.al.
Published By: Saunders/Elsevier2010 in Philadelphia

2010
Chapter Title: Disorders of the Blood
Book Title: Textbook of Medicine
Author List: Zent C and Polliack A
Edited By: Warrel D, Cox T, Firth J
Published By: Oxford2010

1997
Chapter Title: Treatment options for hairy cell leukemia
Book Title: Interferons: biological activities and clinical efficacy
Author List: Zent CS and Golomb HM
Edited By: Aul C, Schneider W
Published By: Springer1997 in Berlin

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