Respiratory Pathogens Research Center (RPRC) RPRC Contract Number: HHSN272201200005C The role of the RPRC is to provide the NIAID Division of Microbiology and Infectious Diseases (DMID) with the capability of conducting translational and clinical research focused on the development and optimization of control measures for viral and bacterial respiratory pathogens. Research conducted under the RPRC shall focus primarily on the development of information, tools, and strategies to decrease the significant global health burden of diseases, such as bacterial pneumonia, influenza, bronchiolitis, and RSV. This also includes studies on viral-bacterial co-infections. Activities include the design, conduct, and analysis of translational, clinical, and innovation research projects. Studies within this Center will be iterative in that results from translational studies will help better inform the design and/or conduct of clinical studies and vice versa. Respiratory pathogens of primary focus include influenza viruses, respiratory syncytial virus (RSV), human coronaviruses, human metapneumoviruses, parainfluenza viruses, Group A Streptococcus, Pneumococcus, Bordetella pertussis, as well as emerging and re-emerging respiratory pathogens.