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Team Science Showcase: Cracking the Code of Chronic Pain

Friday, September 26, 2025

The path to discovery knows no walls. Labs must be nimble, intuitive, and creative to make advancements that will lead to a better understanding of the human body and treatments for disease.

When tackling a complex problem like chronic pain, which the Centers for Disease Control and Prevention estimates affects more than 50 million adults in the United States, researchers from a myriad of specialties need to join forces to ask questions and piece together answers. At the University of Rochester, dentists, neuroscientists, surgeons, psychiatrists, anesthesiologists, nurse practitioners, and others are partnering to gain knowledge and insights that could transform treatment, care, and outcomes.

“I’ve never had any collaborative environment like here. Not everyone can work with you, but everybody will listen and try to find connections,” said Eli Eliav, DMD, PhD, MBA, director of the Eastman Institute for Oral Health at the University of Rochester. “To conduct pain research, a multidisciplinary approach is key. There will never be one molecule or one drug that will solve all the pain problems in the world."

The Team(s)

At the Neuromedicine Pain Center at the University of Rochester Medical Center, neurosurgeons, neurologists, and anesthesiologists partner to create the best care and treatment plans for patients. They also work with neuroscientists like Paul Geha, MD, associate professor of Psychiatry and Neuroscience and a member of the Del Monte Institute for Neuroscience.

He and Jennifer Gewandter, PhD, MPH, associate professor of Anesthesiology and Perioperative Medicine, along with neurosurgeon Steven Soler, MD, recruit people living with pain who are undergoing spinal cord stimulation—a surgery with an average success rate of 50 percent. Prior to implantation of a spinal cord stimulator, patients must undergo psychological testing to make sure important diagnoses, like PTSD or substance abuse, aren’t missed. Their research aims to add outcome prediction to the psychological clearance step with a more comprehensive test.

“Being able to work with Jennifer, who is an expert in clinical trials, helps us maintain that connection between the more mechanistic work we do on the research side with the actual applications in treatment,” Geha said.