Welcome to the Takimoto Lab
The main focus of our research is to reveal molecular mechanism of parainfluenza and influenza virus infection, replication, and assembly and host-virus interactions. We analyze structures and functions of viral proteins as well as interactions between viral and cellular proteins to reveal the mechanism of virus growth and to identify the factors that restrict host range of the viruses. Our study will unveil the process of viral replication and assembly, which are essential for developing antiviral agents.
Current Research Projects
- Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses.Virology. 501, 127-135. (2016 Dec 01).
- Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity.J Virol. 90, 7131-41. (2016 Aug 15).
- Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses.Virology. 487, 11-8. (2016 Jan 01).