Flexor Tendon Tissue Engineering
We are developing clinically-translational paradigms in tissue engineering of flexor tendons, whose injuries are frequently associated with debilitating adhesions. We developed the first mouse model of flexor tendoplasty and associated with this model, we developed an elegant, reproducible biomechanical measure of the adhesions which we coined the "Gliding Coefficient". The mouse model enables mechanistic insights into the etiology of the adhesions following tendoplasty and tissue engineered reconstruction
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Tissue Engineering of Massive Bone Allograft Union
A major research area in my lab is Bone Tissue Engineering. Our approach is to apply biomechanical engineering principles towards developing clinically-translatable functional outcome measures to assess the efficacy of novel treatments and tissue engineering approaches to repair massive segmental defects in long bone.
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Bioreactors for Cartilage Tissue Engineering
Bioreactors are used to optimize various culture factors such as nutrient transport, growth factors, oxygen tension and mechanical stimulation in tissue engineering systems. Some bioreactors have used mechanical stimulation to enhance the synthetic activity of the cells while others have used perfusion fluid flow to enhance nutrient transport and produce homogenous constructs.
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Allograft Derived Scaffolds for Cartilage Repair
Despite the abundance of surgical treatment options, current standards of care for cartilage defects repair have many complications that limit long-term benefits. This has led to development of alternative tissue engineering approaches to enhance cartilage regeneration through combinations of cells (including stem cells) and three-dimensional biomaterial scaffolds.
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Models of Skeletal Disease and Trauma
Our laboratory in the Center for Musculoskeletal Research is also interested in structurally and biomechanically evaluating models of human skeletal disease (e.g. OA and osteoporosis), trauma (e.g. long bone fractures and critical segmental defects), and environmental toxicants (e.g. lead and cigarette smoke) using various wild-type and transgenic mouse models. These musculoskeletal phenotyping studies utilize non-invasive imaging using 3D quantitative micro-CT and biomechanical testing among other techniques.
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