URMC / Labs / Benoit Lab / Publications Recent Publications Malcolm DWFreeberg MATWang YSims KRAwad HABenoit DSW (2017 Nov 13). Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types. Biomacromolecules. Vella JBTrombetta RPHoffman MDInzana JAwad HBenoit DSW (2017 Oct 16). Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure. Journal of biomedical materials research. Part A. Wang YNewman MRAckun-Farmmer MBaranello MPSheu TJPuzas JEBenoit DSW (2017 Sep 26). Fracture-Targeted Delivery of β-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing. ACS nano. Wang YMalcolm DWBenoit DSW (2017 Sep). Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing. Biomaterials. Vats KMarsh GHarding KZampetakis IWaugh REBenoit DS (2017 Apr). Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions. Journal of biomedical materials research. Part A. Shubin ADFelong TJSchutrum BEJoe DSOvitt CEBenoit DS (2016 Dec 27). Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics. Acta biomaterialia. Han SProctor ARVella JBBenoit DSChoe R (2016 Sep 01). Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches. Biomedical optics express. Malcolm DWSorrells JEVan Twisk DThakar JBenoit DS (2016 Jun). Evaluating side effects of nanoparticle-mediated siRNA delivery to mesenchymal stem cells using next generation sequencing and enrichment analysis. Bioengineering & translational medicine. Zhou JHorev BHwang GKlein MIKoo HBenoit DS (2016 May 14). Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms. Journal of materials chemistry. B, Materials for biology and medicine. Newman MRBenoit DS (2016 Apr 8). Local and targeted drug delivery for bone regeneration. Current opinion in biotechnology. Benoit DSKoo H (2016 Apr). Targeted, triggered drug delivery to tumor and biofilm microenvironments. Nanomedicine (London, England). Van Hove AHBurke KAntonienko EBrown EBenoit DS (2015 Nov 10). Enzymatically-responsive pro-angiogenic peptide-releasing poly(ethylene glycol) hydrogels promote vascularization in vivo. Journal of controlled release : official journal of the Controlled Release Society. Hoffman MDBenoit DS (2015 Nov). Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion. Journal of tissue engineering and regenerative medicine. Van Hove AHAntonienko EBurke KBrown EBenoit DS (2015 Jul 7). Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels. Advanced healthcare materials. Han SJohansson JMireles MProctor ARHoffman MDVella JBBenoit DSDurduran TChoe R (2015 Jul 1). Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model. Biomedical optics express. Liyanage WVats KRajbhandary ABenoit DSNilsson BL (2015 Jun 30). Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications. Chemical communications (Cambridge, England). Shubin ADFelong TJGraunke DOvitt CEBenoit DS (2015 Jun). Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications. Tissue engineering. Part A. Hoffman MDBenoit DS (2015 Jun). Emulating native periosteum cell population and subsequent paracrine factor production to promote tissue engineered periosteum-mediated allograft healing. Biomaterials. Burke KADawes RPCheema MKVan Hove ABenoit DSPerry SWBrown E (2015 May). Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels. Journal of biomedical optics. Chen AXHoffman MDChen CSShubin ADReynolds DSBenoit DS (2015 Apr). Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. Journal of biomedical materials research. Part A. Horev BKlein MIHwang GLi YKim DKoo HBenoit DS (2015 Mar 24). pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence. ACS nano. Van Hove AHBenoit DS (2015). Depot-Based Delivery Systems for Pro-Angiogenic Peptides: A Review. Frontiers in bioengineering and biotechnology. Han SHoffman MDProctor ARVella JBMannoh EABarber NEKim HJJung KWBenoit DSChoe R (2015). Non-Invasive Monitoring of Temporal and Spatial Blood Flow during Bone Graft Healing Using Diffuse Correlation Spectroscopy. PloS one. Van Hove AHBeltejar MJBenoit DS (2014 Dec). Development and in vitro assessment of enzymatically-responsive poly(ethylene glycol) hydrogels for the delivery of therapeutic peptides. Biomaterials. Hoffman MDVan Hove AHBenoit DS (2014 Aug). Degradable hydrogels for spatiotemporal control of mesenchymal stem cells localized at decellularized bone allografts. Acta biomaterialia. Baranello MPBauer LBenoit DS (2014 Jul 14). Poly(styrene-alt-maleic anhydride)-based diblock copolymer micelles exhibit versatile hydrophobic drug loading, drug-dependent release, and internalization by multidrug resistant ovarian cancer cells. Biomacromolecules. Vats KBenoit DS (2013 Dec). Dynamic manipulation of hydrogels to control cell behavior: a review. Tissue engineering. Part B, Reviews. Brison JRobinson MABenoit DSMuramoto SStayton PSCastner DG (2013 Nov 19). TOF-SIMS 3D imaging of native and non-native species within HeLa cells. Analytical chemistry. Hoffman MDXie CZhang XBenoit DS (2013 Nov). The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing. Biomaterials. Tsai HYVats KYates MZBenoit DS (2013 Oct 1). Two-dimensional patterns of poly(N-isopropylacrylamide) microgels to spatially control fibroblast adhesion and temperature-responsive detachment. Langmuir : the ACS journal of surfaces and colloids. Arany SBenoit DSDewhurst SOvitt CE (2013 Jun). Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. Hoffman MDBenoit DS (2013 Mar). Emerging ideas: Engineering the periosteum: revitalizing allografts by mimicking autograft healing. Clinical orthopaedics and related research. Van Hove AHWilson BDBenoit DS (2013). Microwave-assisted functionalization of poly(ethylene glycol) and on-resin peptides for use in chain polymerizations and hydrogel formation. Journal of visualized experiments : JoVE. Benoit DSBoutin ME (2012 Nov 12). Controlling mesenchymal stem cell gene expression using polymer-mediated delivery of siRNA. Biomacromolecules. Arany SXu QHernady EBenoit DSDewhurst SOvitt CE (2012 Jun). Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. Journal of cellular biochemistry. Benoit DSSrinivasan SShubin ADStayton PS (2011 Jul 11). Synthesis of folate-functionalized RAFT polymers for targeted siRNA delivery. Biomacromolecules. Brison JBenoit DSMuramoto SRobinson MStayton PSCastner DG (2011 Jan). ToF-SIMS imaging and depth profiling of HeLa cells treated with bromodeoxyuridine. Surface and interface analysis : SIA. Duvall CLConvertine AJBenoit DSHoffman ASStayton PS (2010 Apr 5). Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer. Molecular pharmaceutics. Benoit DSHenry SMShubin ADHoffman ASStayton PS (2010 Apr 5). pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1. Molecular pharmaceutics. Henry SMConvertine AJBenoit DSHoffman ASStayton PS (2009 Jun). End-functionalized polymers and junction-functionalized diblock copolymers via RAFT chain extension with maleimido monomers. Bioconjugate chemistry. Convertine AJBenoit DSDuvall CLHoffman ASStayton PS (2009 Feb 10). Development of a novel endosomolytic diblock copolymer for siRNA delivery. Journal of controlled release : official journal of the Controlled Release Society. Benoit DSSchwartz MPDurney ARAnseth KS (2008 Oct). Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. Nature materials. Rydholm AEHeld NLBenoit DSBowman CNAnseth KS (2008 Jul). Modifying network chemistry in thiol-acrylate photopolymers through postpolymerization functionalization to control cell-material interactions. Journal of biomedical materials research. Part A. Benoit DSTripodi MCBlanchette JOLanger SJLeinwand LAAnseth KS (2007 May). Integrin-linked kinase production prevents anoikis in human mesenchymal stem cells. Journal of biomedical materials research. Part A. Benoit DSDurney ARAnseth KS (2007 Jan). The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation. Biomaterials. Benoit DSCollins SDAnseth KS (2007). Multifunctional hydrogels that promote osteogenic hMSC differentiation through stimulation and sequestering of BMP2. Advanced functional materials. Benoit DSNuttelman CRCollins SDAnseth KS (2006 Dec). Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration. Biomaterials. Benoit DSDurney ARAnseth KS (2006 Jun). Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation. Tissue engineering. Nuttelman CRBenoit DSTripodi MCAnseth KS (2006 Mar). The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs. Biomaterials. Benoit DSAnseth KS (2005 Sep). The effect on osteoblast function of colocalized RGD and PHSRN epitopes on PEG surfaces. Biomaterials.