Skip to main content
Explore URMC

  • Photo of Julie Fudge describing some histology slide on computer
  • Photo of technician working on confocal microscope
  • Photo of technician working with petri dishes

Fudge Lab

Anatomy and Neurochemistry of Major Psychiatric Illnesses

A longstanding focus of our laboratory is examining how pathways through the amygdala are positioned to mediate symptomatology of severe mental illnesses. Over the last decade, multiple human neuroimaging studies show that amygdala dysfunction—its structure, function, or both—is a component of many psychiatric syndromes. Broadly speaking, this is not surprising since the amygdala has long been known to code the salience of external experience. However, the amygdala participates in many diverse and specific functions including fear conditioning and extinction, safety signaling, recognition of emotion in facial expression, and affective responses to primary rewards and punishments. Many of these functions have seemingly opposing goals, raising the question of whether discrete or similar amygdala subregions or cell groups participate in recognizing safety versus reward, or fear learning and extinction. Moreover, the amygdala is a highly heterogeneous structure whose various nuclei have significant differences in structure and connectivity among animal species. Ongoing studies in our laboratory use nonhuman primate models to identify how input/output pathway through the amygdala converge and segregate in order to understand how various types of emotional coding might take place in the human. Because many psychiatric symptoms are brought about by stressful life experiences, we work n collaboration with other nonhuman primate groups, to examine the molecular and cellular features of specific amygdala circuits and subcircuits that are especially important in stress responses. Our work is important in helping to design and interpret outcomes of human neuroimaging work, and we also work with several groups studying manifestations of psychiatric disease in humans.

A new area of study in our laboratory involves models of stress in adolescent rats. Since circuit formation in the amygdala is ongoing during childhood and adolescence, we have several studies investigating the roles of stress on typical amygdala development, and correlated behavioral outcomes.

We invite you to visit our research projects page to see specific projects ongoing in the laboratory.

A word to undergraduates…

We are getting back to our pre-COVID routines, including undergraduate rotations!  See details

Iman MahouiCongratulations to Iman Mahoui, URMC MD candidate, for winning an Academic Year Out fellowship! 

Iman will be joining our lab to study how specific groups of DA neurons connect to the amygdala, and whether these cells are influenced by the stress peptide, CRF.  We look forward to welcoming her formally this summer and moving forward on this exciting project!

Chisom IbeNeURocity Scholar Chisom Ibe 

Summer’s end and a wonderful presentation by Chisom Ibe (right), NeURocity Summer Scholar, on microglia responses to early life stress in macaque amygdala!  Co-mentored by grad student Dennisha King (left) every step of the way.

Julie Fudge, M.D.

Julie Fudge, M.D.
Principal Investigator


Contact Us

  Fudge Lab,
601 Elmwood Ave,
Rochester, NY 14642