Welcome to the Glading Lab
Research in the Glading lab converges on unraveling how cell adhesion signaling regulates cellular behavior. In order for normal cells to function, they must adhere to their immediate environment, which includes other cells and proteins. In return, cells receive both mechanical and chemical signals from their environment that are important for cellular processes such as migration, proliferation, and gene expression. Defective or improperly regulated adhesion is observed in a wide variety of human diseases, including the major killers cancer and cardiovascular disease.
Currently, our work concentrates on how cell-cell adhesion modulates cell growth, differentiation, and tissue morphology in vascular health and disease. Projects in the lab seek to understand how the structural/mechanical and biochemical signals from adhesion sites regulate blood vessel function and growth using cellular and animal models.
We are extremely happy to be funded by a R01 from NIH NHLBI (HL141131), a R21 from NIH NICHD (HD098576), and a FuzeHUB manufacturing grant from the State of New York.