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Jennifer Anolik Receives Lupus Research Alliance Grant

Wednesday, April 26, 2023

Jennifer Anolik, MD, PhD, has received funding through the Lupus Mechanisms and Targets Award from the Lupus Research Alliance. The award is granted to those who have proposed research projects that will explore new potential treatment approaches to prevent lupus from developing, or slow down disease progression. The project’s co-Principal Investigator is Javier Rangel-Moreno, PhD.

The Lupus Mechanisms and Targets Award is for research that focuses on investigating molecular pathways or targets leading to the development of new or improved therapies for patients with cutaneous and systemic lupus erythematosus. The award is for $600,000 over three years.

Anolik’s project will investigate if sodium-glucose cotransporter-2 (SGLT2) inhibitors—a class of drugs approved to treat type 2 diabetes and associated kidney disease—can improve outcomes in lupus nephritis, which is inflammation in the kidneys caused by lupus that affects 40 to 70 percent of lupus patients. Current treatment approaches target inflammation with little impact on fibrosis and injury. Anolik will study mice with lupus nephritis to see if SGLT2 inhibitors reduce kidney hypoxia, inflammatory CD8 T cells, and kidney injury. She will also begin to investigate the effects of treatment with SGLT2i on clinical outcomes and pathogenic CD8 T cells in the blood and urine of patients with lupus nephritis.

“Kidney failure is a major complication for lupus patients,” said Anolik. “We hope that SGLT2 inhibitors will eventually be a new strategy to help prevent this.”

One of Anolik’s lupus patients was in need of a new kidney, then learned she needed a new heart at the same time. This patient underwent a rare dual-organ transplant, and is now thriving thanks to a multi-departmental collaboration.

Faculty and Fellows from Allergy Present Their Work at AAAAI 23

Tuesday, March 28, 2023

The American Academy of Allergy, Asthma & Immunology (AAAAI) held its annual conference last month in San Antonio. The academy can boast of more than 7,000 allergists and immunologists across 74 countries, many of whom convened for the meeting to share research, best practices, and resources in their field.

Several URMC faculty and fellows flew down to share their work and participate in sessions.

“The conference is a great way to reconnect with colleagues in person and exchange ideas about developments in the field,” said Jessica Stern, MD. She was able to highlight collaborative work on improving health inequities in allergic disease. She is working on the national and local level to encourage all learners and faculty to use an equity lens in their work. At the AAAAI meeting different forums and styles were used to deliver this information in an engaging and accessible way.

Drs. Anolik and Rangel-Moreno Receive Lupus Research Funding from the Lupus Research Alliance

Thursday, March 9, 2023

Jennifer Anolik, MD, PhD and Javier Rangel-Moreno, PhD have received funding for their project "SGLT2 Inhibition as a Novel Treatment for Lupus Nephritis,” from the Lupus Research Alliance. Drs. Anolik and Rangel-Moreno will study mice with lupus nephritis to see if SGLT2 inhibitors reduce kidney hypoxia, inflammatory CD8 T cells, and kidney injury.

Drs. Long, Kleiner and Looney Publish Review of Immune Dysregulation

Tuesday, January 17, 2023

Andrew Long, MD, Anatole Kleiner, MD and John Looney, MD recently published a comprehensive review article, “Immune Dysregulation,” in the Journal of Allergy and Clinical Immunology. Read the article.