Welcome to the Muthukrishnan Lab
Welcome to the Muthukrishnan Laboratory at the University of Rochester Medical Center. The research program in the Muthukrishnan Lab aims to understand the immunobiology of musculoskeletal infections, which remains among the most severe and devastating risk associated with orthopaedic surgery. Currently, there are no available immunotherapies to combat these debilitating infections. Our lab is focused on uncovering host-pathogen interactions and the osteoimmunology of orthopaedic infections to aid in novel immunotherapy development. We utilize humanized mouse models, genetic mouse models of human disease, primary human patient samples, high dimensional flow cytometry, next-generation sequencing (scRNAseq, single cell immune profiling), and in vivo imaging techniques to study bone infections.
Gowrishankar Muthukrishnan, Ph.D.
Principal Investigator
Publications
View All Publications- Circulating CD38+ regulatory T cells are decreased in bone fracture non-union with chronic subclinical infection.; Scientific reports. 2026 Apr 27.
- The 2025 International Consensus Meeting on Musculoskeletal Infection: Research Priorities and Future Directions.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 44(4), pp. e70179. 2026 Apr.
- 2025 International Consensus Meeting on Musculoskeletal Infection: Summary From Biofilm Workgroup on Treatment of Biofilm-Related Infection and Preclinical Models.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 44(3), pp. e70169. 2026 Mar.
- Beyond the skin barrier: commensal S. epidermidis imprint systemic immunity to invasive biofilm infection.; bioRxiv : the preprint server for biology. 2026 Jan 09.
Contact Us
Muthukrishnan Lab
MC 1-8545
601 Elmwood Ave
Rochester, NY 14642