Skip to main content
menu

  • Hair Cell Reconstruction
  • Electron Magnet view of hair cell
  • images of cochlea

White Lab

Regeneration After Noise Induced Hearing Loss

Photo of Lab Members

The White Lab

Hearing loss results from prolonged noise exposure. Individual genetics determines each person’s threshold for damage, and by the age of 65 around one third of adults complain of hearing loss. Age-related and noise induced hearing loss are both incurable and progressive, and in many cases are due to the accumulated loss of cochlear mechanosensory hair cells. Sensory hair cells are arrayed in a highly structured epithelial sheet, surrounded by supporting cells with differing shapes and functions. Mammals only generate these specialized cells during fetal development. Once sensory hair cells are lost through over-stimulation, they are never replaced. The adjacent supporting cells expand without cell division to fill the space and create a scar that is insensitive to sound vibrations.

Although there are no signs that deafened mammalian cochleae regenerate, other vertebrates like birds can regain auditory function after damage. This regeneration involves two separable processes:

  • a subset of supporting cells adjacent to the lost sensory hair cells re-enter the cell cycle, replenishing the cell number,
  • partly overlapping subset differentiates into new sensory hair cells.
Photo of Mouse Cochlea

Dissected mouse cochlea with hair cells in red and supporting cells in green. Featured on the cover of Nature.

During my post-doctoral collaborations, we found that purified immature mammalian supporting cells can also divide and differentiate into new sensory hair cells under certain conditions in culture. Moreover, mature mammalian supporting cells can differentiate into sensory hair cells, either in vitro or in response to induction with certain genes. Our findings suggest that sensory hair cell regeneration in mammals may be feasible. Understanding the molecular controls that regulate the processes of regeneration, however, will be key to designing therapies for regenerating sensory hair cells.

Patricia M. White, Ph.D.

Patricia M. White, Ph.D.
Principal Investigator

Publications

    1. Vaara ST
    2. Serpa Neto A
    3. Bellomo R
    4. Adhikari NKJ
    5. Dreyfuss D
    6. Gallagher M
    7. Gaudry S
    8. Hoste E
    9. Joannidis M
    10. Pettilä V
    11. Wang AY
    12. Kashani K
    13. Wald R
    14. Bagshaw SM
    15. Ostermann M
    16. Bagshaw SM
    17. Wald R
    18. Adhikari NKJ
    19. Bellomo R
    20. Dreyfuss D
    21. Du B
    22. Gallagher MP
    23. Gaudry S
    24. Hoste EA
    25. Lamontagne F
    26. Joannidis M
    27. Liu KD
    28. McAuley DF
    29. McGuinness SP
    30. Nichol AD
    31. Ostermann M
    32. Palevsky PM
    33. Qiu H
    34. Pettilä V
    35. Schneider AG
    36. Smith OM
    37. Vaara ST
    38. Weir M
    39. Bellomo R
    40. Eastwood GM
    41. Peck L
    42. Young H
    43. Kruger P
    44. Laurie G
    45. Saylor E
    46. Meyer J
    47. Venz E
    48. Wetzig K
    49. French C
    50. McGain F
    51. Mulder J
    52. Fennessy G
    53. Koottayi S
    54. Bates S
    55. Towns M
    56. Morgan R
    57. Tippett A
    58. Udy A
    59. Mason C
    60. Licari E
    61. Gantner D
    62. McClure J
    63. Nichol A
    64. McCracken P
    65. Board J
    66. Martin E
    67. Vallance S
    68. Young M
    69. Vladic C
    70. McGloughlin S
    71. Gattas D
    72. Buhr H
    73. Coles J
    74. Hutch D
    75. Wun J
    76. Cole L
    77. Whitehead C
    78. Lowrey J
    79. Masters K
    80. Gresham R
    81. Campbell V
    82. Gutierrez D
    83. Brailsford J
    84. Forbes L
    85. Murray L
    86. Maguire T
    87. NiChonghaile M
    88. Orford N
    89. Bone A
    90. Elderkin T
    91. Salerno T
    92. Chimunda T
    93. Fletcher J
    94. Broadfield E
    95. Porwal S
    96. Knott C
    97. Boschert C
    98. Smith J
    99. Richardson A
    100. Hill D
    101. Duke G
    102. Oziemski P
    103. Cegarra S
    104. Chan P
    105. Welsh D
    106. Hunter S
    107. Roodenburg O
    108. Dyett J
    109. Kokotsis N
    110. Moser M
    111. Yang Y
    112. Padayachee L
    113. Vetro J
    114. Gangopadhyay H
    115. Kaufman M
    116. Ghosh A
    117. Said S
    118. Patel A
    119. Bihari S
    120. Matheson E
    121. Jin X
    122. Shrestha T
    123. Schwartz K
    124. Gallagher MP
    125. Cross R
    126. Cheung W
    127. Wong H
    128. Kol M
    129. Shah A
    130. Wang AY
    131. Endre Z
    132. Bradford C
    133. Janin P
    134. Finfer S
    135. Diel N
    136. Gatward J
    137. Hammond N
    138. Delaney A
    139. Bass F
    140. Yarad E
    141. Buscher H
    142. Reynolds C
    143. Baker N
    144. Joannidis M
    145. Bellmann R
    146. Peer A
    147. Hasslacher J
    148. Koglberger P
    149. Klein S
    150. Zotter K
    151. Brandtner A
    152. Finkenstedt A
    153. Ditlbacher A
    154. Hartig F
    155. Fries D
    156. Bachler M
    157. Schenk B
    158. Wagner M
    159. Staudinger T
    160. Tiller E
    161. Schellongowski P
    162. Bojic A
    163. Hoste EA
    164. Bracke S
    165. De Crop L
    166. Vermeiren D
    167. Thome F
    168. Chiella B
    169. Fendt L
    170. Antunes V
    171. Maisonneuve-Rosemont
    172. Lafrance JP
    173. Lamontagne F
    174. D'Aragon F
    175. St-Arnaud C
    176. Mayette M
    177. Carbonnaeu É
    178. Marchand J
    179. Masse MH
    180. Ladouceur M
    181. Turgeon AF
    182. Lauzier F
    183. Bellemare D
    184. Langis Francoeur C
    185. LeBlanc G
    186. Guilbault G
    187. Grenier S
    188. Cloutier E
    189. Boivin A
    190. Delisle-Thibault C
    191. Giannakouros P
    192. Costerousse O
    193. Cailhier JF
    194. Carrier FM
    195. Ghamraoui A
    196. Lebrasseur M
    197. Benettaib F
    198. Salamé M
    199. Boumahni D
    200. Tung Sia Y
    201. Naud JF
    202. Roy I
    203. Stelfox HT
    204. Ruddell S
    205. Manns BJ
    206. Duggan S
    207. Carney D
    208. Barchard J
    209. Whitlock RP
    210. Belley-Cote E
    211. Savija N
    212. Sabev A
    213. Campbell T
    214. Creary T
    215. Devereaux K
    216. Brodutch S
    217. Rigatto C
    218. Paunovic B
    219. Mooney O
    220. Glybina A
    221. Harasemiw O
    222. Di Nella M
    223. Harmon J
    224. Mehta N
    225. Lakatos L
    226. Haslam N
    227. Lellouche F
    228. Simon M
    229. Tung Y
    230. Lizotte P
    231. Bourchard PA
    232. Rochwerg B
    233. Karachi T
    234. Millen T
    235. Muscedere J
    236. Maslove D
    237. Gordon Boyd J
    238. Sibley S
    239. Drover J
    240. Hunt M
    241. Georgescu I
    242. Wax R
    243. Lenga I
    244. Sridhar K
    245. Steele A
    246. Fusco K
    247. Ghate T
    248. Tolibas M
    249. Robinson H
    250. Weir MA
    251. Taneja R
    252. Ball IM
    253. Garg A
    254. Campbell E
    255. Ovsenek A
    256. Bagshaw SM
    257. van Diepen S
    258. Baig N
    259. Magder S
    260. Yao H
    261. Alam A
    262. Campisi J
    263. MacIntyre E
    264. Rokosh E
    265. Scherr K
    266. Lapinsky S
    267. Mehta S
    268. Shah S
    269. Niven DJ
    270. Stelfox HT
    271. Ruddell S
    272. Russell M
    273. Jim K
    274. Brown G
    275. Oxtoby K
    276. Hall A
    277. Benoit L
    278. Sokolowski C
    279. Prasad B
    280. Rao J
    281. Giebel S
    282. Kutsogiannis DJ
    283. Thompson P
    284. Thompson T
    285. Cirone R
    286. Kavikondala K
    287. Soth M
    288. Clarke F
    289. Takaoka A
    290. Wald R
    291. Mazer D
    292. Burns K
    293. Friedrich J
    294. Klein D
    295. Sandhu G
    296. Santos M
    297. Khalid I
    298. Hodder J
    299. Dodek P
    300. Ayas N
    301. Alcuaz V
    302. Suen G
    303. Rewa O
    304. Singh G
    305. Norris S
    306. Gibson N
    307. Arias C
    308. Shami A
    309. Pelletier C
    310. Adhikari NKJ
    311. Zahirieh A
    312. Amaral A
    313. Marinoff N
    314. Kaur N
    315. Perez A
    316. Wang J
    317. Haljan G
    318. Condin C
    319. McIntyre L
    320. Gomes B
    321. Porteous R
    322. Watpool I
    323. Hiremath S
    324. Clark E
    325. Herridge MS
    326. Backhouse F
    327. Elizabeth Wilcox M
    328. Walczak K
    329. Ki V
    330. Sharman A
    331. Romano M
    332. Bagshaw SM
    333. Noel Gibney RT
    334. Romanovsky AS
    335. Rewa O
    336. McCoshen L
    337. Baig N
    338. Wood G
    339. Ovakim D
    340. Auld F
    341. Carney G
    342. Duan M
    343. Ji X
    344. Guo D
    345. Qi Z
    346. Lin J
    347. Zhang M
    348. Dong L
    349. Liu J
    350. Liu P
    351. Zhi D
    352. Bai G
    353. Qiu Y
    354. Yang Z
    355. Bai J
    356. Liu Z
    357. Zhuang H
    358. Wang H
    359. Li J
    360. Zhao M
    361. Zhou X
    362. Shi X
    363. Ye B
    364. Liu M
    365. Wu J
    366. Fu Y
    367. Long D
    368. Pan Y
    369. Wang J
    370. Mei H
    371. Zhang S
    372. Wen M
    373. Yang E
    374. Mu S
    375. Li J
    376. Hu T
    377. Qin B
    378. Li M
    379. Wang C
    380. Dong X
    381. Wang K
    382. Wang H
    383. Yang J
    384. Du B
    385. Wang C
    386. Wang D
    387. Li N
    388. Yu Z
    389. Xu S
    390. Yao L
    391. Hou G
    392. Liu Z
    393. Lu L
    394. Lian Y
    395. Wang C
    396. Zhang J
    397. Ding R
    398. Qi G
    399. Wang Q
    400. Wang P
    401. Meng Z
    402. Chen M
    403. Hu X
    404. He X
    405. Zhao S
    406. Hang L
    407. Li R
    408. Qin S
    409. Lu K
    410. Dun S
    411. Liu C
    412. Zhou Q
    413. Chen Z
    414. Mei J
    415. Zhang M
    416. Xu H
    417. Lin J
    418. Shi Q
    419. Fu L
    420. Zeng Q
    421. Ma H
    422. Yan J
    423. Gao L
    424. Liu H
    425. Zhang L
    426. Li H
    427. He X
    428. Fan J
    429. Guo L
    430. Liu Y
    431. Wang X
    432. Sun J
    433. Liu Z
    434. Yang J
    435. Ding L
    436. Sheng L
    437. Liu X
    438. Yan J
    439. Wang Q
    440. Wang Y
    441. Zhao D
    442. Zhao S
    443. Hu C
    444. Li J
    445. Deng F
    446. Qiu H
    447. Yang Y
    448. Mo M
    449. Pan C
    450. Wu C
    451. Huang Y
    452. Huang L
    453. Liu A
    454. Pettilä V
    455. Vaara ST
    456. Korhonen AM
    457. Törnblom S
    458. Sutinen S
    459. Pettilä L
    460. Heinonen J
    461. Lappi E
    462. Suhonen T
    463. Karlsson S
    464. Hoppu S
    465. Jalkanen V
    466. Kuitunen A
    467. Levoranta M
    468. Långsjö J
    469. Ristimäki S
    470. Malila K
    471. Wootten A
    472. Varila S
    473. Järvisalo MJ
    474. Inkinen O
    475. Kentala S
    476. Leivo K
    477. Haltia P
    478. Dreyfuss D
    479. Ricard JD
    480. Messika J
    481. Tiagarajah A
    482. Emery M
    483. Dechanet A
    484. Gernez C
    485. Roux D
    486. Martin-Lefevre L
    487. Fiancette M
    488. Vinatier I
    489. Claude Lacherade J
    490. Colin G
    491. Lebert C
    492. Azais MA
    493. Yehia A
    494. Pouplet C
    495. Henry-Lagarrigue M
    496. Seguin A
    497. Crosby L
    498. Maizel J
    499. Titeca-Beauport D
    500. Combes A
    501. Nieszkowska A
    502. Masi P
    503. Demoule A
    504. Mayaux J
    505. Dres M
    506. Morawiec E
    507. Decalvele M
    508. Demiri S
    509. Faure M
    510. Marios C
    511. Mallet M
    512. Amélie Ordon M
    513. Morizot L
    514. Cantien M
    515. Pousset F
    516. Gaudry S
    517. Poirson F
    518. Cohen Y
    519. Argaud L
    520. Cour M
    521. Bitker L
    522. Simon M
    523. Hernu R
    524. Baudry T
    525. De La Salle S
    526. Robine A
    527. Sedillot N
    528. Tchenio X
    529. Bouisse C
    530. Roux S
    531. Barbar D
    532. Trusson R
    533. Tamion F
    534. Grangé S
    535. Carpentier D
    536. Chevrel G
    537. Ensenyat-Martin L
    538. Marque S
    539. Quenot JP
    540. Andreu P
    541. Dargent A
    542. Large A
    543. Chudeau N
    544. Landais M
    545. Derrien B
    546. Christophe Callahan J
    547. Guitton C
    548. Le Moal C
    549. Robert A
    550. Asehnoune K
    551. Cinotti R
    552. Grillot N
    553. Demeure D
    554. Vinsonneau C
    555. Rahmani I
    556. Marzouk M
    557. Dekeyser T
    558. Sejourne C
    559. Verlay M
    560. Thevenin F
    561. Delecolle L
    562. Didier Thevenin L
    563. Souweine B
    564. Coupez E
    565. Adda M
    566. Eraldi JP
    567. Marchalot A
    568. De Prost N
    569. Mekontso Dessap A
    570. Razazi K
    571. Meziani F
    572. Boisrame-Helms J
    573. Clere-Jehl R
    574. Delabranche X
    575. Kummerlen C
    576. Merdji H
    577. Monnier A
    578. Rabouel Y
    579. Rahmani H
    580. Allam H
    581. Chenaf S
    582. Franja V
    583. Pons B
    584. Carles M
    585. Martino F
    586. Richard R
    587. Zuber B
    588. Lacave G
    589. Lakhal K
    590. Rozec B
    591. Dang Van H
    592. Boulet É
    593. Dubos R
    594. Fadel F
    595. Cleophax C
    596. Dufour N
    597. Grant C
    598. Thuong M
    599. Reignier J
    600. Canet E
    601. Nicolet L
    602. Boulain T
    603. Nay MA
    604. Benzekri D
    605. Barbier F
    606. Bretagnol A
    607. Kamel T
    608. Mathonnet A
    609. Muller G
    610. Skarzynski M
    611. Rossi J
    612. Pradet A
    613. Dos Santos S
    614. Guery A
    615. Muller L
    616. Felix L
    617. Bohé J
    618. Thiéry G
    619. Aissaoui N
    620. Vimpere D
    621. Commeureuc M
    622. Diehl JL
    623. Guerot E
    624. Liangos O
    625. Wittig M
    626. Zarbock A
    627. Küllmar M
    628. van Waegeningh T
    629. Rosenow N
    630. Nichol AD
    631. Brickell K
    632. Doran P
    633. Murray PT
    634. Landoni G
    635. Lembo R
    636. Zangrillo A
    637. Monti G
    638. Tozzi M
    639. Marzaroli M
    640. Lombardi G
    641. Paternoster G
    642. Vitiello M
    643. McGuinness S
    644. Parke R
    645. Butler M
    646. Gilder E
    647. Cowdrey KA
    648. Wallace S
    649. Hallion J
    650. Woolett M
    651. Neal P
    652. Duffy K
    653. Long S
    654. McArthur C
    655. Simmonds C
    656. Chen Y
    657. McConnochie R
    658. Newby L
    659. Knight D
    660. Henderson S
    661. Mehrtens J
    662. Morgan S
    663. Morris A
    664. Vander Hayden K
    665. Burke T
    666. Bailey M
    667. Freebairn R
    668. Chadwick L
    669. Park P
    670. Rolls C
    671. Thomas L
    672. Buehner U
    673. Williams E
    674. Albrett J
    675. Kirkham S
    676. Jackson C
    677. Browne T
    678. Goodson J
    679. Jackson D
    680. Houghton J
    681. Callender O
    682. Higson V
    683. Keet O
    684. Dominy C
    685. Young P
    686. Hunt A
    687. Judd H
    688. Lawrence C
    689. Olatunji S
    690. Robertson Y
    691. Latimer-Bell C
    692. Hendry D
    693. Mckay-Vucago A
    694. Beehre N
    695. Lesona E
    696. Navarra L
    697. Robinson C
    698. Jang R
    699. Junge A
    700. Lambert B
    701. Schneider AG
    702. Thibault M
    703. Eckert P
    704. Kissling S
    705. Polychronopoulos E
    706. Poli E
    707. Altarelli M
    708. Schnorf M
    709. Abed Mallaird S
    710. Heidegger C
    711. Perret A
    712. Montillier P
    713. Sangla F
    714. Neils S
    715. De Watteville A
    716. Phull MK
    717. George A
    718. Hussain N
    719. Pogreban T
    720. Lobaz S
    721. Daniels A
    722. Cunningham M
    723. Kerr D
    724. Nicholson A
    725. Shanmugasundaram P
    726. Abrams J
    727. Manso K
    728. Hambrook G
    729. McKerrow E
    730. Salva J
    731. Foulkes S
    732. Wise M
    733. Morgan M
    734. Brooks J
    735. Cole J
    736. Michelle Davies T
    737. Hill H
    738. Thomas E
    739. Vizcaychipi M
    740. Baharlo B
    741. Carungcong J
    742. Costa P
    743. Martins L
    744. Kapoor R
    745. Hazelton T
    746. Moon A
    747. Musselwhite J
    748. Shelley B
    749. McCall P
    750. Ostermann M
    751. Arbane G
    752. Bociek A
    753. Marotti M
    754. Lim R
    755. Campos S
    756. Grau Novellas N
    757. Cennamo A
    758. Slack A
    759. Wyncoll D
    760. Camporota L
    761. Sparkes S
    762. Tilley R
    763. Rattray A
    764. Moreland G
    765. Duffy J
    766. McGonigal E
    767. Hopkins P
    768. Finney C
    769. Smith J
    770. Noble H
    771. Watson H
    772. Harris CL
    773. Clarey E
    774. Corcoran E
    775. Beck J
    776. Howcroft C
    777. Youngs N
    778. Wilby E
    779. Ogg B
    780. Wolverson A
    781. Lee S
    782. Butler S
    783. Okubanjo M
    784. Hindle J
    785. Welters I
    786. Williams K
    787. Johnson E
    788. Patrick-Heselton J
    789. Shaw D
    790. Waugh V
    791. Stewart R
    792. Mwaura E
    793. Wren L
    794. Mew L
    795. Sutherland SB
    796. Adderley J
    797. Ruddy J
    798. Harkins M
    799. Kaye C
    800. Scott T
    801. Mitchell W
    802. Anderson F
    803. Willox F
    804. Jagannathan V
    805. Clark M
    806. Purv S
    807. Sharman A
    808. Meredith M
    809. Ryan L
    810. Conner L
    811. Peters C
    812. Harvey D
    813. Roshdy A
    814. Collins A
    815. Sim M
    816. Henderson S
    817. Chee N
    818. Pitts S
    819. Bowman K
    820. Dilawershah M
    821. Vamplew L
    822. Howe E
    823. Rogers P
    824. Hernandez C
    825. Prendergast C
    826. Benton J
    827. Rosenberg A
    828. Forni LG
    829. Grant A
    830. Carvelli P
    831. Raithatha A
    832. Bird S
    833. Richardson M
    834. Needham M
    835. Hirst C
    836. Ball J
    837. Leaver S
    838. Howlett L
    839. Castro Delgado C
    840. Farnell-Ward S
    841. Farrah H
    842. Gray G
    843. Joseph G
    844. Robinson F
    845. Tridente A
    846. Harrop C
    847. Shuker K
    848. McLaughlan D
    849. Ramsey J
    850. Meehan S
    851. Oliver Rose B
    852. Reece-Anthony R
    853. Gurung B
    854. Whitehouse T
    855. Snelson C
    856. Veenith T
    857. Johnston A
    858. Cooper L
    859. Carrera R
    860. Ellis K
    861. Fellows E
    862. Harkett S
    863. Bergin C
    864. Spruce E
    865. Despy L
    866. Goundry S
    867. Dooley N
    868. Mason T
    869. Clark A
    870. Dignam G
    871. Ward G
    872. Attwood B
    873. Parsons P
    874. Mason S
    875. Margarson M
    876. Lord J
    877. McGlone P
    878. Hodgson LE
    879. Chadbourn I
    880. Gomez R
    881. Margalef J
    882. Pretorius R
    883. Hamshere A
    884. Carter J
    885. Cahill H
    886. Grainger L
    887. Howard K
    888. Forshaw G
    889. Guy Z
    890. Kashani KB
    891. Albright RC
    892. Amsbaugh A
    893. Stoltenberg A
    894. Niven AS
    895. Lynch M
    896. O'Mara A
    897. Naeem S
    898. Sharif S
    899. McKenney Goulart J
    900. Lynch M
    901. O'Mara A
    902. Naeem S
    903. Sharif S
    904. McKenney Goulart J
    905. Tolwani A
    906. Lyas C
    907. Latta L
    908. Bihorac A
    909. Hashemighouchani H
    910. Efron P
    911. Ruppert M
    912. Cupka J
    913. Kiley S
    914. Carson J
    915. White P
    916. Omalay G
    917. Brown S
    918. Velez L
    919. Marceron A
    920. Neyra JA
    921. Carlos Aycinena J
    922. Elias M
    923. Ortiz-Soriano VM
    924. Hauschild C
    925. Dorfman R
    Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.; Critical care explorations; Vol 6(2), pp. e1053. 2024 Feb 19.
    1. Na D
    2. Zhang J
    3. Beaulac HJ
    4. Piekna-Przybylska D
    5. Nicklas PR
    6. Kiernan AE
    7. White PM
    Corrigendum: Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.; Frontiers in neuroscience; Vol 17, pp. 1250244. 2023 Jul 18.
    1. Na D
    2. Zhang J
    3. Beaulac HJ
    4. Piekna-Przybylska D
    5. Nicklas PR
    6. Kiernan AE
    7. White PM
    Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.; Frontiers in neuroscience; Vol 17, pp. 1106570. 2023 May 26.
    1. Piekna-Przybylska D
    2. Na D
    3. Zhang J
    4. Baker C
    5. Ashton JM
    6. White PM
    Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation.; Frontiers in cellular neuroscience; Vol 16, pp. 1096872. 2023 Jan 06.

View All Publications

Contact Us

  Patricia White Lab
MC 6-8529
601 Elmwood Ave,
Rochester, NY 14642