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Yang H., Hou H., Pahng A., Gu H., Nairn A.C., Tang Y.P., Colombo P.J. and Xia H. Protein phosphatase-1 inhibitor-2 is a novel memory suppressor. Journal of Neuroscience (2015) Nov 11; 35(45):15082-15087.

Hou H., Chávez A.E., Wang C.C., Yang H., Gu H., Sidddoway B.A, Hall B.J., Castillo P.E. and Xia H.  The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. Journal of Neuroscience (2014) Oct 15; 34(42):14006-14012. PMID: 25319697

Siddoway, B.A., Hou, H., Yang, J., Sun, L., Yang, H., Wang, G. and Xia, H. Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity. Neuroscience Letter (2014) Sep 8;583C:142-147.

Siddoway, B.A., Hou, H., Xia H. Molecular mechanisms of synaptic downscaling.Neuropharmacology(2014) Mar, 78:38-44. PMID: 23911745.

Siddoway B., Hou H., Yang H., Petralia R.S. and Xia H Identification of a bidirectionally-regulated, sequence-specific phosphoproteome in mammalian neurons that regulates protein expression. Journal of Neurochemistry (2014) Mar, 128(6):841-51. PMID: 24117848.

Hou H., Sun L., Siddoway B., Petralia R.S., Yang H., Gu H., Nairn A. and Xia H. Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5. Journal of Cell Biology(2013) Nov. 11, 203(3). PMCID: PMC3824016

Our work was highlighted in the JCB:

2014 10:36:57 AMMoreover, AAAs and EurekAlert has sent out a Public release regarding our work:

Siddoway B., Altimimi F.H., Hou H., Petralia R., Stellwagen, D. and Xia H. An essential role of inhibitor-2 regulated protein phosphatase-1 in synaptic downscaling. Journal of Neuroscience(2013) July 3, 33(27):11206-11211.  PMCID: PMC3718377.

Siddoway, B., Hou, H., Xia H.  Glutamatergic Synapses: Molecular organization.  Encyclopedia of Life Sciences(2011), DOI: 10.1002/9780470015902.a0000235.pub2.

Dong C., Yang L., Zhang X., Gu H., Lam M.L., Claycomb W.C., Xia H., Wu G. Rab8 interacts with distinct motifs in a2B- and b2-adrenergic receptors and differentially modulates their transport.J Biol Chem. 2010 Apr 27, 285: 20369-20380  PMCID: PMC2888448

Gao, J., Siddoway, B., Huang, Q., Xia, H: Inactivation of CREB mediated gene transcription by HDAC targeted protein phosphatase. Biochem Biophys Res Commun. (2009) 379:1-5.

Hu, X.D., Huang, Q., Yang, X., Xia, H: Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus Journal of Neuroscience(2007) 27:4674-86.

Hu, X.D., Huang, Q., Roadcap, D.W., Shenolikar, S.S., Xia, H: Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. Journal of Neurochemistry(2006) 98:1841-51.

Deisseroth, K., Mermelstein, P.G., Xia, H. and Tsien, R.W: Signaling from synapse to nucleus: the logic behind the mechanisms. Curr Opin Neurobiol (2003) 13:76-80.

Xia, H., von Zastrow, M., Malenka, R.C: A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. J Biol Chem (2002) 277:47765-47769.

Braithwaite, S., Xia, H., Malenka, R.C: Differential Roles of NSF and GRIP in AMPA receptor cycling. Proc Natl Acad Sci USA (2002) 99:7096-7101.

Morishita, W., Connor, J.H., Xia, H., Quinlan, E., Shenolikar, S., Malenka, R.C: Regulation of synaptic strength by protein phosphatase 1 Neuron(2001) 32:1133-1148.

Xia, H., Hornby, Z.D., Malenka, R.C: An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits. Neuropharmacology (2001) 41:714-723.

Selected Papers:

Gao, J., Hu, X.D., Xia, H: Neurabin is a PKA substrate critical for LTD induction.
(manuscript in preparation)

Huang, Q., Lee, I-P., Medina, V., Xia, H: Structural determinant in cycloxygenase-2 in its nuclear envelope and ER localization. (manuscript in preparation)

Gao, J., Siddoway, B., Xia, H: Differential effects of neurabin and spinophilin in spine maturation. (manuscript in preparation)

Carroll, R.C., Beattie, E.C., Xia, H., Lscher, C., Altschuler, Y., Nicoll, R.A., Malenka, R.A., von Zastrow, M: Dynamin-dependent endocytosis of ionotropic glutamate receptors, Proc Natl Acad Sci USA  (1999) 96:14112-14117.

Xia, H., Fitzgerald, J., Bredt, D.S., Forsayeth, J.R: Detection of mycoplasma infection of mammalian cells, Biotechniques (1997) 22:934-936.

Brenman, J., Xia, H., Chao, D., Black, S., Bredt, D.S: Regulation of neuronal nitric oxide synthase through alternative transcripts, Dev Neurosci(1997) 19:224-231.

Chao, D.S., Silvagno, F., Xia, H., Cornwell, T.L., Lincoln, T.M., Bredt, D.S: Nitric oxide synthase and cyclic GMP-dependent protein kinase concentrated at the neuromuscular endplate, Neuroscience (1997) 76:665-672.

Xia, H., Winocur, S., Kuo, W., Waltherr, M., Bredt, D.S: Actinin-associated LIM protein: identification of a domain interaction between a PDZ motif and spectrin-like repeat, J Biol Chem(1997) 139:507-515.

Brenman, J.E., Chao, D.S., Gee, S.H., McGee, A.W., Craven, S.E., Santillano, D.R., Wu, Z., Huang, F., Xia, H., Peters, M., Froehner, S.C., Bredt, D.S: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains, Cell(1996) 84:757-767.

Holtzman, D.M., Lee, S., Li, Y., Chua-Couzens, J., Xia, H., Bredt, D.S., Mobley, W.C: Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF, Neurochem Res(1996) 21:861-868.

Silvagnano, F.*, Xia, H.*, Bredt, D.S: Neuronal nitric oxide synthase-m, an alternatively spliced isoform uniquely expressed in differentiated skeletal muscle, J Biol Chem (1996) 271:11204-11208.

Xia, H., Bredt, D.S: Cloned and expressed nitric oxide synthase proteins, Meth Enzymol(1996) 268:427-436.

Brenman, J., Chao, D., Xia, H., Aldape, K., Bredt, D.S: Nitric Oxide synthase complexed with dystrophin in skeletal muscle and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy,Cell (1995) 82:743-752.