Faculty
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism. 
Toxicology of inhaled particulate matter on the lung, cardiovascular, and central nervous systems
Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages. 
Defining molecular pathways by which inhaled allergens and particulates activate lung mucosal immunity.
Pneumocystis carinii pneumonia; Infections in the immunocompromised host
Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Effect of lifestyle, human milk, and infant microbiome of development of immune system and allergic diseases.
Cellular and molecular mechanisms of lung fibrosis; new treatments for interstitial lung diseases
Defining the impact of environmental exposures on immune system development and function, with emphasis on how early life exposures shape health and disease later in life.
Investigates prenatal and early life nutritional and environmental exposures that impact the development of asthma and affect lung growth.
Genetic and environmental susceptibility to developmental lung injury.
Airway epithelial stem cells in chemical inhalation exposures.
Defining how gene environment interactions shape alveolar lung development and the risk for lung disease over the lifespan.
Biokinetics, Effects, Mechanisms and Risk of Inhaled Particles: Dosimetry; Neuronal Nano-Particle Translocation Nose to Brain; Translation Human to Rodent and vice-versa.
Team approaches to patient-centered, clinical and translational investigation in sepsis and critical illness
Multiple molecular modality identification of lung cell types, subtypes and states in health and disease with focus on diseases of children.
The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Environmental lung diseases COPD and IPF pathogenesis and therapeutic targets: effects of lung cellular mitochondrial dysfunction, senescence, and molecular clock.
Molecular determinants of and clinical outcomes related to normal and abnormal development of the adaptive immune system in human infants.
Immune responses to respiratory viruses and experimental vaccines
Thrombosis and platelet activation in vascular pathology of pulmonary hypertension; clinical trial design in pulmonary hypertension
