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URMC / Medicine / Nephrology / Research / Keith Nehrke

Keith Nehrke

NSF
IOS-1352836
K. Nehrke PI
Mitochondrial Regulation of Calcium Signaling in C. elegans
05/01/14-04/30/17
NIH
R01-GM087483
K. Nehrke and P. Brookes, co-PIs
C. Elegans and Mitochondrial K+ Channels
01/01/10-12/31/17
NIH
R01-HL127891
K. Nehrke and P. Brookes, co-PIs
The Role of the Mitochondrial UPR in Ischemic Protection
04/01/15-02/29/19

Our laboratory studies mechanisms by which external cues regulate systems functions. Integrative approaches in the nematode C. elegans and mammalian cardiac models focus on how membrane electrolyte flux and pH regulation exhibit environmental responses to inform metabolism, physiology, and ultimately survival. Funded projects center around the role of mitochondria in oscillatory calcium signaling, metabolic plasticity, and sensitivity to ischemia-reperfusion injury.