Alexandra McHale Awarded 2017 Trainee Professional Development Award
Thursday, September 7, 2017
Join us in congratulating Ally for receiving this award from the Society for Neuroscience. The award will support travel to this year’s meeting in Washington, DC, and a special poster session for all trainees at the meeting. Ally will also benefit from admission to Professional Development Workshops, and presentation of her poster in the meeting at-large, Wednesday November 15.
Friday, September 1, 2017
The newest issue of opportunities to explore is now available, The newsletter contains information on events, resources, and more!
Highlight - Registration Closes Next Week
URBEST Retreat and Career Workshops (Lunch Registration Deadline: Friday, September 8th)
Thursday, September 14 | 8:30 am - 4:00 pm | Class of 62 and CEL Classrooms, URMC
This year’s retreat includes guest presenter Randy Ribaudo from SciPhD joining us to present The Art of Negotiation and Networking for Success. Speakers and round-table leaders will be LeRon Nelson, Assistant Professor of Nursing; Ed Brydon, Social Media Strategist at Weill Cornell Medicine; Kirk Macolini, President & Principal Consultant at InteliSpark, LLC; Kurt Schilling, SVP Research and Technologies at The Estée Lauder Companies Inc.; and Judith Dunn, VP Global Head Clinical Development at Roche. There will be ice cream and therapy dogs at this year’s event also! Register for the event online at surveymonkey.com/r/17URBESTRetreat.
Register for URBEST Retreat and Career Workshop
Celebrating a Community of Diverse Students and Trainees at URMC (RSVP by Friday, September 8th)
Sunday, September 17 | 1:00 pm - 4:00 pm | Canal side Shelter Genesee Valley Park
Sponsored by URMC: Clinical and Transitional Science Institute, Executive Committee for Diversity and Inclusion, Office for Inclusion and Cultural Development, School of Medicine and Dentistry, and School of Nursing invite you and your families to join them for food, fun, and games, to celebrate our community of diverse students and trainees at the University of Rochester Medical Center.
RSVP for Celebrating a Community of Diverse Students and Trainees at URMC
Read More: Latest Issue of Opportunities To Explore - September 4-8
Tuesday, August 15, 2017
“Researchers have long fixed their attention on eye-tracking in detecting autism spectrum disorders, but now they may have discovered a new tool that could lead to earlier diagnosis and intervention.” the research is by John Foxe, the Kilian J. and Caroline F. Schmitt Professor in Neuroscience and chair of the Department of Neuroscience.
In a July 12 article in the European Journal of Neuroscience, researchers at the University of Rochester linked differences in the cerebellar vermis (in the rear of the cerebellum, which controls the development of human movement, social skills and emotional development) to the plasticity of saccadic or rapid eye movements within a subgroup of people with disorders on the autism spectrum (ASD).
Rapid eye movements (also known as saccade) may be the key, say Edward G. Freeman, Ph.D., and John J. Foxe Ph.D. These eye movements-typically quick, precise and accurate in healthy eyes-occur when we shift our gaze between objects and are important in interacting with the world. Sometimes though, in people with ASD, the movements can "over- or undershoot the intended target locations," they wrote in the study.Read More: Study Uncovers Potential Tool, Based on Rapid Eye Movements, for Detecting Autism Earlier
Friday, July 28, 2017
Newly appointed Dept. of Neuroscience faculty member, Farran Briggs, Ph.D. has her research highlighted on Wired.
When ferrets get a rabies shot in a neurobiology lab, they don't get infected with the virus—or even inoculated against it. They get a brain hack that might just explain how your brain handles vision, and maybe even your other senses, too.
In a lab at Dartmouth, scientists are experimenting with targeted injections of a modified rabies virus into the brains of ferrets—essentially allowing them to control how the animal responds to simple visual patterns. The goal is to understand the brain's enormously complex visual processing system. But really? Rabies? Ferrets? Are these guys just screwing around?
Lots of visual research depends on lab mice—the most popular of model organisms in biology. But Dartmouth neuroscientist and lead author Farran Briggs wanted to study an animal that uses its vision the same way humans do, in an evolutionary sense: to prey on tasty snacks. Mice aren’t predators, and their vision falls solidly in the ‘legally blind’ range. So these vision researchers turned to the notoriously vicious ferret and its front-facing eyes. They're color blind, but at the neural level, ferrets’ visual systems have “remarkable similarities to a primate, and a human,” says Briggs. (Ferrets also help avoid the ethical issues of experimenting on primates.)Read More: Scientists Inject Ferrets' Brains With Rabies to Study ... Vision?
Monday, July 24, 2017
A new study out in European Journal of Neuroscience could herald a new tool that helps physicians identify a sub-group of people with Autism spectrum disorders (ASD). The test, which consists of measuring rapid eye movements, may indicate deficits in an area of the brain that plays an important role in emotional and social development.
“These findings build upon a growing field of research that show that eye movement could serve as a window into a part of the brain that plays a role in a number of neurological and development disorders, such as Autism,” said John Foxe, Ph.D., director of the University of Rochester Medical Center Del Monte Neuroscience Institute and co-author of the study.
ASD is characterized by a wide range of symptoms that can vary in severity from person to person. This unpredictability not only presents a challenge for diagnosis, but also how best to devise a course of treatment. Identifying the specific phenotype of the disorder is, therefore, an essential first step to providing effective care.
"Read More: Eye Test Could Help Diagnose Autism
Congratulations Drs. Cavanaugh and O'Donnell
Friday, July 21, 2017
Matt Cavanaugh successfully defended his PhD thesis on Monday, July 17th! Matt will be staying at the URMC as a post-doc with Dr. Steve Feldon. Matt will be running a clinical trial, under Dr. Feldon, on the training program they developed in lab to bring it through the FDA approval process.
John O’Donnell successfully defended his PhD thesis on Monday, July 17th! John will be starting a post-doc with Dr. Joel Perlmutter at Washington University in Saint Louis this fall, studying neuromodulators in cognitive decline in Parkinson's Disease.
NIH Grant to Examine ‘Person-Centered’ Approach to Cognitive Training
Thursday, July 20, 2017
The National Institutes of Health has awarded a grant to URMC researchers exploring methods of making cognitive training more effective for older adults by improving their attitudes toward computers.
Feng Vankee Lin, Ph.D., RN, an SON assistant professor and director of the CogT Lab promoting successful aging, and Benjamin Chapman, Ph.D., MPH, associate professor of Psychiatry, are principal investigators on the $421,000, two-year study.
Computerized cognitive training methods, such as online “brain games” have been widely implemented among adults with mild cognitive impairment (MCI) in recent years. However those interventions have not proven to be a consistently reliable method of improving or maintaining the cognitive health of older adults. Results are highly variable, and one possible explanation lies in how comfortable seniors feel using technology.
“The goal of this study is to generate a proof-of-concept for an intervention that may improve attitudes toward computers among those older adults with MCI,” said Lin, who is now principal or co-investigator on six current NIH grants. “Improving the intervention engagement of those individuals, we think, will then help us develop more effective computerized cognitive interventions in the future. It is the first study that we know of that strives to augment computerized cognitive training by addressing an attitudinal or affective element of the person.”
At the core of the study is the notion of person-centered care – integrating individuals’ preference throughout the process of intervention. The person-centered approached has been shown to improve engagement among older persons, including those with MCI, and pilot data collected at assisted-living facilities suggests that computer-led leisure activities promotes psychological well-being among older persons with MCI and may change their perception about technology. A computer used for fun activities may no longer seem daunting, complex, or irrelevant, but instead be seen as familiar and enjoyable.
“These results are consistent with a number of theories indicating that exposure to pleasurable experiences with an object or task improves several dimensions of attitudes, including affective and cognitive components, as well as behavior and motivation,” Lin said.
Grounded in this pilot data and the theory around it, investigators will lead a small randomized controlled trial among assisted-living residents to assess whether a period of computer-led leisure activities prior to cognitive training improves attitudes toward computers, engagement with the intervention, or cognitive outcomes.
Anton Porsteinsson, M.D., professor of Neurology, is a co-investigator on the grant, which is also receiving recruitment support from Dallas Nelson, M.D., and Sarah Howd, M.D., in the Department of Medicine’s Division of Geriatrics and Aging.
Monday, July 10, 2017
The ubiquitous human herpesvirus 6 (HHV-6) may play a critical role in impeding the brain’s ability to repair itself in diseases like multiple sclerosis. The findings, which appear in the journal Scientific Reports, may help explain the differences in severity in symptoms that many people with the disease experience.
“While latent HHV-6 – which can be found in cells throughout the brain – has been associated with demyelinating disorders like multiple sclerosis it has not been clear what role, if any, it plays in these diseases,” said Margot Mayer-Proschel, Ph.D., an associate professor at the University of Rochester Medical Center Department of Biomedical Genetics and co-author of the study. “These findings show that, while in the process of hiding from the immune system, the virus produces a protein that has the potential to impair the normal ability of cells in the brain to repair damaged myelin.”
"Read More: Hidden Herpes Virus May Play Key Role in MS, Other Brain Disorders
Friday, June 16, 2017
Ed Freedman and John Foxe have just published preliminary data from a study examining eye movement changes in individuals with Autism Spectrum Disorders (ASD), particularly looking at the role of the cerebellum (DOI: 10.1111/ejn.13625). The cerebellum, Latin for ‘little’ brain, sits at the base of brain, underneath the cerebral cortex. Although it has been called ‘mini’, the cerebellum actually has more neurons, or cells, than the cerebral cortex. Classically considered to play a role in the control of movements and the learning of motor patterns, it is now known to play a role in emotion and cognition through its connection to the rest of the brain. And, there is evidence that the structure of the cerebellum is altered in a sub-population of individuals with ASD.
In the current paper, Ed and John present the results of experiments tracking the rapid eye-movements made when looking from one object to another, or saccades, in individuals with ASD. Accuracy and precision are maintained by careful comparison of the movement command produced by the brain and the results of the actual movement. Any differences between these lead to adjustments of the commands for ensuing saccades. This type of sensorimotor adaptation is dependent on the proper functioning of the cerebellum. However, there is anatomical evidence that some people with an ASD have cerebella with slightly altered structure. If the cerebellar structure is altered, is its function also altered in this sub-group of people? Assessing the ability of people with an ASD to adapt saccade amplitudes is one way to determine whether this function of the cerebellum is altered in ASD.
Another point of interest is determining if the deficits in saccades relate to any of the other key symptoms observed in ASD.
If saccade adaptation deficits do turn out to be a consistent finding in a sub-group of children with ASD, this raises the possibility that saccade adaptation measures may have utility as an early-detection endophenotype. Changes in cerebellar structure most likely occur in utero and very recent work has shown that saccadic adaptation can be measured in children as young as 10-41 months of age is a most encouraging development indeed. - Ed and JohnRead More: Ed Freedman and John Foxe Publish in EJN
Faculty Honored at SON End of Year Awards
Thursday, May 25, 2017
Feng (Vankee) Lin, Ph.D., RN, assistant professor, received the Terry Family Research Fund Education for the Center for Outcomes Measurement and the Elaine C. Hubbard Center for Nursing Research on Aging Endowed Award. The awards will further their research on the neural mechanisms of — and interventions to improve — older adults’ social connectedness.
Wednesday, May 24, 2017
A recent scientific study shows that insufficient amount of sleep leads to the development of Alzheimer's disease. Researchers gain more evidence and are beginning to believe that lack and poor quality of sleep results to the fusion of Amyloids, proteins that bond together to form Alzheimer's plaques.
Dr. Maiken Nedergaard, the lead researcher from the University of Rochester Medical Center, explains the glymphatic system that is present in humans. She says that this system is 10 times more active when in slumber than when awake. The process allows cerebrospinal fluid to flow through spaces around the neurons of people's brains. This a method of purging unwanted proteins (Amyloids) and other wastes into the circulatory system garbage collectors and eventually flushes it out of the body.
In simple terms, Nedergaard explains that the brain has its own sanitation and public works department. It is like a network of sewer facilities mostly done during the brain's nightlife. An example of a housekeeping staff descending to building offices for a cleanup duty to avoid the lumping compound that causes Alzheimer's.Read More: Featured in The Science Times: How Alzheimer's Catches People Skimping Sleep: New Study Explains Cause Of Dementia
Keshov Sharma Presents Late-Breaking Data at Society for Biological Psychiatry in San Diego
Monday, May 22, 2017
Keshov Sharma, a second-year student in the Medical Scientist Training Program (MSTP), presented work collected in part during his laboratory last summer at the SOBP Annual meeting in May. The study, “Dual Neural Connections between the Amygdala and the Ventromedial (BA25) and Dorsomedial (BA24) Prefrontal Cortex in the Macaque”, was inspired by recent data in rodents implicating separate subcircuits between amygdala and infralimbic cortex, and amygdala and the prelimbic cortex, in fear extinction and fear consolidation, respectively. To find a comparable bridge to human fear studies, we designed studies to examine this question in monkeys because of their relatively larger and more subdivided cortical architecture that parallels the human. Analyzing dual retrograde injections into proposed ‘homologues’ of these rodent cortical regions in monkeys, we found that cells projecting to these cortical regions were mostly intermixed in several specific amygdala subnuclei in primates. Moreover, a subpopulation of neurons projected to both prefrontal regions, indicating common neural modulation of these functionally dissociated areas. Thus, amygdala inputs to separable, functionally opposed cortical regions exist in close proximity to one another in specific parts of the amygdala, and some of these cells participate in both ‘subcircuits’. Understanding this organization may provide clues about how to ‘tip the balance’ between fear learning and fear extinction learning in higher species, including humans that suffer from illnesses characterized by aberrant fear learning.
Introducing the Center for NeuroTherapeutics Discovery
Tuesday, May 16, 2017
The Center for Neural Development and Disease, led by Harris A. (Handy) Gelbard, M.D., Ph.D., since 2008, will now be the Center for NeuroTherapeutics Discovery, reflecting an increased emphasis on translation and the creation of intellectual property that will lead to new therapies for nervous system disorders.
Gelbard, professor of Neurology, Pediatrics, Neuroscience and Microbiology & Immunology, will continue as director. His research, coupled with the work of Charles Thornton, M.D., professor of Neurology and Neuroscience, and Marc Halterman, M.D., Ph.D., associate professor of Neurology, Neuroscience and Pediatrics, will serve as the anchor of the new center. The trio has a strong track record of grants, publications, and patents, as well as academic and commercial relationships that they are actively pursuing to bring new treatments to the public.
“The Center for NeuroTherapeutics Discovery was developed out of the Center for Neural Development and Disease to create more visibility for academic and commercial partnerships as a necessary bridge for bringing new therapeutics forward,” said Gelbard. “This represents a way to do the best and most cutting edge science possible in a time when the traditional avenues towards funding academic research are changing rapidly.”
The center will bring together many investigators from across the Medical Center and River Campus to identify the mechanisms that lead to various neurological disorders, including HIV-associated neurocognitive disorder (Gelbard lab), myotonic dystrophy (Thornton lab) and stroke (Halterman lab). The center remains committed to its members that investigate the molecular signaling events that lead to nervous system disease during development and aging. Industry partnerships and resources will be sought to fast-track existing therapies or create new molecules that affect these disease mechanisms.
Treatments that harness the immune system to help regenerate damaged cells will be a major focus at the center; the team believes that this approach is broadly applicable to a range of acute and chronic neurodegenerative disorders, such as Parkinson’s disease, multiple sclerosis and Alzheimer’s disease.
Dr. Adam Rouse Receives an NIH K99/R00 Award
Friday, May 12, 2017
Dr. Adam Rouse, Post-doctoral Fellow in Neuroscience, recently received an NIH K99/R00 Pathway to Independence Award from the National Institute of Neurological Disorders and Stroke (NINDS). His project “Neural encoding of motor precision for advancing brain-machine interfaces” will study how motor areas of the brain encode different movements and use advanced mathematical models to build brain-machine interfaces that are more precise and intuitive to the user. In addition to his current mentor, Dr. Marc Schieber, Professor in Neurology and Neuroscience, the award will also support Dr. Rouse’s career development with additional mentoring from Dr. Robert Jacobs, Professor in Brain and Cognitive Sciences, and Dr. Sridevi Sarma, Associate Professor in Biomedical Engineering at Johns Hopkins University.
Dean’s Teaching Fellowship Recipients Named
Thursday, April 27, 2017
The 2017-2019 Dean’s Teaching Fellows have been named. Beau Abar, Ph.D., assistant professor of Emergency Medicine, has been named the Paul F. Griner Dean’s Teaching Fellow. Jessica Shand, M.D., MHS, assistant professor of Pediatrics, has been named the George L. Engel Dean’s Teaching Fellow. Katherine Greenberg, M.D., assistant professor of Adolescent Medicine and Obstetrics and Gynecology, has been named the Jules Cohen Dean’s Teaching Fellow. Linda Callahan, Ph.D., assistant professor of Neuroscience, has been named the Lawrence E. Young Dean’s Teaching Fellow.
The Dean’s Teaching Fellowship Program is a competitive endowed two-year program for faculty who are dedicated to academic careers in medical education. The mission of the program is to develop faculty who can prepare medical students, residents, and practicing physicians to become professionals who are responsive to society’s needs and the ever-changing health care system.
The program typically accepts four Fellows a year who attend a three-hour, bi-weekly seminar series focused on different areas of educational theory, research and teaching methods, educational technology, assessment, curriculum design, faculty development, leadership and career planning. During their time in the program, Fellows conduct a scholarly educational project that is directly translatable to their teaching role and will culminate in a publication or presentation at a national meeting.
Thursday, April 27, 2017
Two University of Rochester start-up companies are among those singled out in a new report from the Science Coalition. The report, “American-Made Innovation Sparking Economic Growth,” identifies 102 companies that trace their roots to federally-funded university research.Read More: University start-ups highlighted in national innovation report
“The innovation that drives economic growth in the U.S. is based, in large part, on the scientific discoveries made in research universities and funded by the federal government,” said Rob Clark, University provost and senior vice president for research. “As a nation, it is imperative that we continue to support the fundamental science that leads to new technologies and improves lives.”
Clerio Vision was founded in 2014 by Wayne Knox and Jon Ellis with the Institute of Optics, and Krystel Huxlin with the Flaum Eye Institute in the Medical Center. The company is developing a new technology that improves eyesight by “writing” a prescription on the cornea using small pulses from a laser that change the focusing power of the eye. Because the technique doesn’t change the shape of the cornea like LASIK procedures, it can be repeated as needed over a person’s lifetime to correct vision. The research to develop the technology was funded in part with a $200,000 grant from the National Institutes of Health (NIH).
Duje Tadin Awarded NARSAD Independent Investigator Award from the Brain and Behavior Research Foundation
Tuesday, April 25, 2017
Recently Dr. Duje Tadin, Associate Professor in Brain and Cognitive Sciences and at the Center for Visual Science won the NARSAD Independent Investigator Award from the Brain and Behavior Research Foundation. The title of his project is “A critical role of perceptual inefficiencies in working memory abnormalities in schizophrenia”. He also has a pending application to the Simons Foundation’s SFARI Pilot Awards program with a project titled “Functional consequences of elevated internal noise in autism.”
2017 Curtis Award
Monday, April 24, 2017
Neuroscience Graduate Program student Jessica Hogestyn, a student in the Mayer-Pröschel Lab, has been selected as one of the winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. Her nomination material exemplified her ability as an outstanding educator with bright future.
Monday, April 24, 2017
Researchers have discovered that a protein implicated in human longevity may also play a role in restoring hearing after noise exposure. The findings, where were published in the journal Scientific Reports, could one day provide researchers with new tools to prevent hearing loss.
The study reveals that a gene called Forkhead Box O3 (Foxo3) appears to play a role in protecting outer hair cells in the inner ear from damage. The outer hair cells act as a biological sound amplifier and are critical to hearing. When exposed to loud noises, these cells undergo stress. In some individuals, these cells are able to recover, but in others the outer hair cells die, permanently impairing hearing. While hearing aids and other treatments can help recovered some range of hearing, there is currently no biological cure for hearing loss.
“While more than a hundred genes have been identified as being involved in childhood hearing loss, little is known about the genes that regulate hearing recovery after noise exposure,” said Patricia White, Ph.D., a research associate professor in the University of Rochester Medical Center Department of Neuroscience and lead author of the study. “Our study shows that Foxo3 could play an important role in determining which individuals might be more susceptible to noise-induced hearing loss.”Read More: Gene May Hold Key to Hearing Recovery
Congratulations Drs. McConnell and Wang
Wednesday, April 19, 2017
It has been a very busy and successful spring for the NGP students. Evan McConnell, MD/PhD student successfully defended his PhD thesis on Wednesday, April 12 and Xiaowei Wang passed her final PhD examination on Monday, April 17, 2017. Both students come from Dr. Maiken Nedergaard lab.
Congratulations to both!
Wednesday, April 12, 2017
New study details “physical therapy” for eyes
DeMay fixes his gaze on a live image of his own eye
in preparation for the next round of training.
Patients who went partially blind after suffering a stroke regained large swaths of rudimentary sight after undergoing visual training designed by researchers at the University of Rochester Medical Center’s Flaum Eye Institute.
A new study out today in Neurology®, the medical journal of the American Academy of Neurology, provides the first evidence that rigorous visual training recovers basic vision in cortically blind patients with long-standing stroke damage in the primary visual cortex. Damage to this area of the brain prevents visual information from getting to other brain regions that help make sense of it, causing loss of sight in one-quarter to one-half of an individual’s normal field of view. Somewhere between 250,000 and 500,000 people suffer vision loss due to damage to the visual cortex each year.
“We are the only people in the U.S. currently using this type of training to recover vision lost after damage to the primary visual cortex,” said study senior author Krystel Huxlin, Ph.D., director of Research and James V. Aquavella, M.D. Professor of Ophthalmology at URMC’s Flaum Eye Institute. “If you talk to the majority of clinicians, they still believe nothing can be done.”Read More: Retraining the Brain to See After Stroke
Congratulations Dr. Mai
Monday, April 10, 2017
Nguyen Mai, an MD/PhD student in Dr. Marc Halterman's lab, has successfully defended her thesis.You can watch a stream of her defense from the URMC Panopto site.
Congratulations Dr. Nguyen!
Thursday, March 30, 2017
New research reveals the complex circuits involved in regulating the neurotransmitter dopamine in our brains. Traditionally thought to be limited to reward seeking, the new study shows that parts of the ‘emotional’ brain may also manipulate dopamine to help us pay attention and react to new information in the environment.
The study, which appears in the journal Neuropsychopharmacology, was led by Julie Fudge, M.D., with the University of Rochester Medical Center (URMC) Department of Neuroscience.
The research focuses on an area of the brain called the amygdala, which is known to be important for social and emotional development and behaviors. The amygdala receives sensory information – sight, sound, and smells – and processes it by combining it with information stored in our memories. It evaluates changes or new information to help determine whether it is worthy of our attention or if it can be ignored. The new study shows that one way the amygdala can accomplish this is by communicating with the brain’s dopamine producing cells.Read More: Study Shed New Light on Brain’s Decision-making Process
Berkeley Fahrenthold successfully defends her PhD thesis
Monday, March 20, 2017
Berkeley Fahrenthold, a graduate student in Dr. Rick Libby's lab, successfully defended her PhD thesis titled,"Assessment of the involvement of intrinsic and extrinsic cell death pathways in retinal ganglion cell death after excitotoxic injury".
Congratulations Dr. Fahrenthold!!!
Monday, March 20, 2017
Professor Edward Brown has received NIH funding for his research project titled, "Using Second Harmonic Generation to Predict Metastatic Outcome in Colon Adenocarcinoma."
"In summary, we previously discovered that an optical scattering phenomenon from primary tumor samples provides an independent prognostic indicator of time to metastasis in colon cancer patients," Professor Brown says. "With this grant we will explore if and how this can be used to improve prediction of outcomes for individual patients, leading to improved therapy decisions."
When treating a colon adenocarcinoma (CA) patient, after surgical resection of the tumor the clinician must formulate a plan for adjuvant systemic therapy. This decision is based upon an assessment of the risk of systemic disease recurrence, and is currently informed by pathological factors such as stage, histological grade, and lymph node status. Improvement of the accuracy of risk assessment for individual patients is an area of recognized need. Much of the current information used to assess risk focuses on the cells within tumors, including their morphological properties. Less attention is paid to the extracellular matrix through which metastasizing cells must travel. Second harmonic generation (SHG) is an optical scattering phenomenon whose directionality (as quantified by the “F/B” ratio) is affected by the diameter, spacing, and disorder of fibrils within collagen fibers. Our preliminary data suggests that F/B analysis of tumor samples provides prognostic information about future metastasis that is “matrix-focused” and hence complementary to current “cell-focused” methods. Consequently we hypothesize that F/B is a clinically useful predictor of metastatic outcome in colon adenocarcinoma. In a preliminary study in 44 Stage I colon adenocarcinoma samples we found that F/B of the primary tumor is a significant prognostic indicator of progression free survival time. Significantly, the quartile of patients with the lowest F/B ratio had a 15 year progression free survival percentage of below 50%. In other words, in this study F/B could identify a subset of Stage I patients who had survival statistics similar to Stage III patients. Stage I patients are rarely prescribed adjuvant chemotherapy while Stage III patients are almost always prescribed it. This suggests that F/B can identify patients who would have benefitted from adjuvant chemotherapy and who were left untreated based upon current prognostic indicators. The prognostic trend was also evident in a cohort of 72 Stage II colon adenocarcinoma samples, although it was not significant. This project will move this idea closer to the clinic by first (Aim 1) using archived samples and follow up data in separate training and validation sets to develop predictive algorithms that include F/B, in addition to clinical and genomic information. Second it will (Aim 2) quantify the effect of adjuvant chemotherapy on the predictive ability of the algorithms, as well as quantify their ability to predict chemotherapeutic efficacy. We predict that F/B analysis will be an effective tool that can reach the clinic rapidly after this study to improve metastatic risk assessment. Improving the accuracy of risk estimation for an individual patient will allow clinicians to treat those patients who are destined for metastases, improving outcomes, while avoiding treatment for those patients who are not, reducing overtreatment.Read More: Professor Ed Brown receives NIH grant for research project, "Using Second Harmonic Generation to Predict Metastatic Outcome in Colon Adenocarcinoma"
Monday, March 6, 2017
Caring for a loved one with dementia can be very
stressful, but two URMC research studies are
exploring ways to help caregivers manage stress
and improve their own health.
Caring for a loved one with Alzheimer’s disease or dementia can not only be very stressful, but can negatively affect the well-being of the caregiver. A pair of studies at the University of Rochester Medical Center is exploring ways to help caregivers manage stress and improve their own health so they can more effectively provide care for their loved one.
Kathi Heffner, Ph.D., associate professor in the School of Nursing and Department of Psychiatry, and Jan Moynihan, Ph.D., the George L. Engel Professor in Psychosocial Medicine in the Departments of Psychiatry and Microbiology and Immunology, were awarded more than $5.66 million in NIH funding for two five-year randomized clinical intervention trials focusing on reducing the effects of caregiving on immune health.
Heffner is principal investigator on a cognitive training intervention trial looking at different types of brain training activities and whether they have an effect on the aging of the caregiver’s immune system. Moynihan is leading a study on mindfulness-based stress reduction (MBSR), to see if mindfulness can lead to better immune response to the influenza vaccine.Read More: Clinical Trials Aim to Reduce Stress Burden for Dementia Caregivers
SFN Rochester Chapter News
Thursday, March 2, 2017
The grant application to support the Rochester Society for Neuroscience chapter was recently funded due to efforts by Past President, Doug Portman. Thanks to Doug’s efforts and excellent leadership over the last two years, we can continue our efforts to increase neuroscience awareness and education in our community.
The current Chapter President, Liz Romanski, would like to congratulate the organizers and volunteers for hosting a very successful, first ever, Rochester Brain Bee on February 11, 2017 (picture attached). Ten students from high schools in the Rochester area competed in the Brain Bee, answering questions spanning a large body of neuroscience facts covering brain development, cognition, disease processes, neuroimaging, etc. The three finalists in the Brain Bee were:
- Neli Kotlyar, Pittsford Mendon High School (grade 10)
- Maha Khokhar, Pittsford Sutherland High School (grade 12)
- Kathryn Gentile, Pittsford Mendon High School (grade 11)
Heather Natola and Nicole Peltier were the organizers of the Brain Bee, and were assisted by volunteers from the Brain Awareness committee including Neuroscience graduate students Jessie Hogestyn and Josh Hinkle, and BCS grad students Alyssa Kersey, Carol Jew, and Matt Overlan. The winner of the Brain Bee will fly to Baltimore, MD in March for the National Brain Bee. Funding was made possible by the Society for Neuroscience Chapter, the Neuroscience Graduate Program, and the Department of Neuroscience with prizes from local businesses and donations from Drs. Huxlin and Nehrke. Great job all!
Professor Edward Brown and Professor Catherine K. Kuo receive grant from Department of Defense office of the Congressionally Directed Medical Research Programs
Thursday, February 23, 2017
The Department of Defense office of the Congressionally Directed Medical Research Programs has awarded Professor Edward Brown and Professor Catherine K. Kuo a grant for their research project titled, "Understanding the Role of Matrix Microstructure in Metastasis.” The goal of this project is to evaluate molecular mechanisms underlying the ability of an optical scattering phenomenon to predict metastatic outcome in patient samples.
Tuesday, February 21, 2017
Nina Schor, M.D., Ph.D., William H. Eilinger Chair of Pediatrics and the pediatrician-in-chief at UR Medicine’s Golisano Children’s Hospital, has been named the recipient of the Child Neurology Society’s 2017 Hower Award, the organization’s highest honor.
The award is given annually to a child neurologist for being an outstanding teacher, scholar, and for making high levels of contributions to the field and to the Child Neurology Society. Schor, who has spent much of her career researching neuroblastoma, one of the most common childhood cancers, will be recognized at the society’s annual meeting in October, in Kansas City, Mo. She will also have the honor of giving the annual Hower lecture.
“I am so honored and excited to accept this award and present the associated lecture to an audience comprised of my colleagues, friends, mentors, and trainees,” said Schor.
The Child Neurology Society is the preeminent non-profit professional association of pediatric neurologists in the United States, Canada, and worldwide. Schor, the University of Rochester Medical Center’s seventh Chair of the Department of Pediatrics, joined the university in 2006.Read More: Schor to Receive Child Neurology Society's Highest Honor
Project Explores Machine Learning to Help Predict Alzheimer’s Disease
Friday, February 17, 2017
Feng Vankee Lin, assistant professor of Nursing, and Rajeev Raizada, assistant professor of Brain and Cognitive Sciences, have been awarded a Collaborative Pilot Award in Health Analytics from the Goergen Institute for Data Science.
The one-year project will use big data in an effort to develop an algorithm for predicting Alzheimer’s disease. The project will analyze large brain-imaging datasets and use multiple machine-learning approaches to uncover diagnostic patterns and create a more reliable predictive model for detecting Alzheimer’s disease.
“It will help initiate a new research area focusing on neuroimaging methodology development in relation to Alzheimer’s disease,” said Lin.
The award includes a $35,000 grant for the project, which runs from Feb. 1, 2017 to Jan. 31, 2018.
Located in Wegmans Hall, the Goergen Institute for Data Science is a hub for interdisciplinary data science research. Its work in health analytics – using data to predict individual health outcomes – includes advances in using data to help analyze the brain more effectively and sharing the data with other researchers to discover more ways to improve outcomes for patients.
Shawn Newlands Appointed Associate CMO for Ambulatory Care
Thursday, February 9, 2017
In a move that reflects the importance of our expanding outpatient network, Shawn Newlands, M.D., Ph.D., M.B.A, has been appointed to the newly created role of Associate Chief Medical Officer for URMC’s ambulatory care enterprise.
“In many ways, this role formalizes and expands the successful work Shawn already does as chair of URMFG’s Clinical Operations Committee, where he has helped build a solid framework for faculty input and oversight of guidelines, policies and other decisions that impact the delivery of patient care in our ambulatory settings,” said Michael F. Rotondo, M.D., F.A.C.S., CEO of URMFG. “As a proven leader who builds consensus and finds the middle ground amid disparate views, he will be a focused and effective guide for our ambulatory enterprise.”
Monday, January 30, 2017
Major Step toward Longer-Lasting HIV Treatment
A drug developed at the University of Rochester Medical Center extends the effectiveness of multiple HIV therapies by unleashing a cell’s own protective machinery on the virus. The finding, published today in the Journal of Clinical Investigation, is an important step toward the creation of long-acting HIV drugs that could be administered once or twice per year, in contrast to current HIV treatments that must be taken daily.
The drug, called URMC-099, was developed in the laboratory of UR scientist Harris A. (“Handy”) Gelbard, M.D., Ph.D. When combined with “nanoformulated” versions of two commonly used anti-HIV drugs (also called antiretroviral drugs), URMC-099 lifts the brakes on a process called autophagy.
Normally, autophagy allows cells to get rid of intracellular “trash,” including invading viruses. In HIV infection, the virus prevents cells from turning on autophagy; one of the many tricks it uses to survive. When the brake on autophagy is lifted, cells are able to digest any virus that remains after treatment with antiretroviral therapy, leaving cells free of virus for extended periods of time.
Harris A. (“Handy”) Gelbard, M.D., Ph.D.
“This study shows that URMC-099 has the potential to reduce the frequency of HIV therapy, which would eliminate the burden of daily treatment, greatly increase compliance and help people better manage the disease,” said Gelbard, professor and director of UR’s Center for Neural Development and Disease, who has studied HIV/AIDS for the past 25 years. The finding builds on previous research that Gelbard conducted with Howard E. Gendelman, M.D., professor and chair of the Department of Pharmacology/Experimental Neuroscience at the University of Nebraska Medical Center.Read More: URMC Drug Extends Effectiveness of HIV Therapy
Liz Romanski to serve as President of Rochester Chapter of Society for Neuroscience
Wednesday, January 25, 2017
Liz Romanski, Associate Professor of Neuroscience at the University of Rochester, will serve as President of the Rochester Chapter of the Society for Neuroscience for the 2017-2108 term.
The Chapter is involved in a number of activities designed to strengthen Neuroscience research, education, and outreach in the Rochester area. In addition to Dr. Romanski, the Chapter's current leadership council includes Secretary/Treasurer Chris Holt, Faculty Councilor Amy Kiernan, Past Presidents Krystel Huxlin and Doug Portman, Postdoctoral Councilor Sarah Heilbronner, Graduate Student Councilor Heather Natola, and Administrative Coordinator Ania Dworzanski.
Tuesday, January 24, 2017
A study led by Jessica Cantlon, associate professor of brain and cognitive sciences, suggests that primates have the ability to distinguish large and small quantities of objects, irrespective of the surface area they appear to occupy.
Adults and children in the US, adults from a 'low numeracy' tribe in Bolivia and rhesus monkeys ALL possessed the ability to distinguish between large and small quantities of objects, regardless of the surface area they occupy. This ability is likely a shared evolutionary trait, according to a study. The nonverbal visual tests could be used in assessing early math education in young children.Read More: What humans, primates both know when it comes to numbers
Julianne Feola successfully defends thesis
Wednesday, January 18, 2017
Congratulations to Julianne Feola on completing her PhD degree on Monday, January 17, 2017. Julie was a student in Dr. Gail Johnson lab. She wrote a PhD thesis on The Role of Astrocytic Transglutaminase 2 in mediating Cellular Viability Processes.
Best luck, Julie!