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Paul Geha, M.D.

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Appointment: (585) 276-3000

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

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I have expertise in the neuroscience of pain, hedonics and feeding, and multimodal neuroimaging. I use a broad range of neuroimaging techniques, and behavioral testing to study the neurobiology of acute and chronic pain, analgesia, and obesity. My research program focuses on understanding mechanisms of neuro-adaptation in chronic pain and obesity, neural response to analgesic treatment, and brain derived long-term predictors of clinical outcomes. My current focus is mapping the brain signature of different chronic pain conditions using different imaging modalities to discover and validate these signatures. My laboratory has recently published (PNAS 2020) the first brain signature of chronic back pain that is highly reproducible across chronic back pain patients' cohorts collected in different laboratories. I have used neuroimaging and behavioral tools in cross-sectional, longitudinal and therapeutic designs to identify brain biomarkers of chronic pain and modulate these biomarkers with analgesic interventions.



  • Psychiatry - American Board of Psychiatry and Neurology


MD | American University of Beirut

Post-doctoral Training & Residency

07/01/2012 - 06/30/2014
Fellowship in Psychiatry at Veterans Affairs Medical Center

07/01/2009 - 06/30/2012
Residency in Psychiatry at Yale New Haven Hospital

07/01/2008 - 06/30/2009
Internship in Internal Medicine & Psychiatry at Yale New Haven Hospital

10/08/2003 - 06/30/2008
Fellowship in Neurophysiology at Northwestern University, Feinberg School of Medicine

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Seymour L. Lustman Award for Psychiatric Research, Dept. of Psychiatry, Yale University School of Medicine
Sponsor: Yale University
Location: New Haven CT

Clinical Trials

Cortical Pathophysiology of Chronic Pain

Lead Researcher: Paul Geha

This study will use subjective rating methods, computer-based games, and brain imaging to study the characteristics of chronic pain and brain processes that cause them. By so doing we hope to obtain new information and understanding of chronic pain across multiple conditions. Eligibility: Ages 18-65; in generally stable health; diagnosed with a pain condition: Chronic back pain (CBP), Osteoarthritis of the knee (OAk), Temporomandibular joint disorder(TMJ), Complex regional pain syndrome (CRPS), or Pelvic Pain (PP).

View Study Details


Journal Articles

Murray K, Lin Y, Makary MM, Whang PG, Geha P. "Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study." Molecular pain. 2021 17:1744806921990938.

Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. "Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain." Proceedings of the National Academy of Sciences of the United States of America.. 2020 May 5; 117(18):10015-10023. Epub 2020 Apr 20.

Geha P, Schulman BR, Dib-Hajj SD, Waxman SG. "Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning." . 2018 3:8-14. Epub 2018 Jan 31.