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NIH Taps URMC to Help Develop New Pain Relievers to Combat Opioid Crisis

Wednesday, October 16, 2019

University of Rochester Medical Center (URMC) researchers have been selected as part of a national initiative by the National Institutes of Health (NIH) to develop new non-addictive treatments for pain to improve patient care and curb the use and abuse of opioids.

The URMC awards are part of a $945 million in grants recently announced under the NIH Helping to End Addition Long-term Initiative (NIH HEAL), which was created to improve treatments for chronic pain, reduce opioid use disorder and overdoses, and achieve long-term recovery from opioid addiction. This initiative represents the largest ever financial commitment by NIH to a single research program.

It is estimated that 50 million adults in the U.S. suffer from chronic pain and 10 million people misuse opioids, including heroin. More than 400,000 Americans have died from overdoses of prescription pain narcotics, heroin, and fentanyl since 1999.

URMC researchers have been selected to carry out clinical trials for new non-addictive pain therapies and provide national leadership to the NIH Early Phase Pain Investigation Clinical Network (EPPIC-Net), which consists of clinical research experts from across different specialties in academia, foundations, and industry.

One URMC project will be led by John Markman, M.D., director of the Department of Neurosurgery's Translational Pair Research Program and Jennifer Gewandter, Ph.D., M.P.H., assistant professor in the Department of Anesthesiology and Perioperative Medicine. The Medical Center will serve as a hub for a group of institutions that includes the Children's Hospitals and Clinics of Minnesota, the University of Miami, Rutgers University, and the Carolinas Pain Institute that will conduct clinical trials for new pain relief therapies. Thirteen dedicated principal investigators at URMC will recruit subjects with a broad range of pain conditions from anesthesiology, dentistry, emergency medicine, gastroenterology, gynecology, neurology, neurosurgery, oncology, orthopedics, pediatrics, rheumatology, and urology.

The URMC-led project is one of 12 hub-and-spoke research clusters chosen as part of the NIH EPPIC-Net program.

"The urgency to develop more effective and safer pain treatments has never been greater," said Markman. "This initiative will enable us to better understand chronic pain mechanisms and the biologic basis for different pain conditions and why some patients respond differently to pain treatments."

Read More: NIH Taps URMC to Help Develop New Pain Relievers to Combat Opioid Crisis

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