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Student Seminars

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Sounds in silence: How glial cells in the ear promote maturation of the auditory system

Dwight Bergles, Ph.D. - The Soloman H. Snyder Department of Neuroscience
Johns Hopkins University School of Medicine

Kavli Neuroscience Discovery Institute

Neural pathways that process sensory information rely on both genetically preprogrammed events and active refinement to establish proper connectivity. Remarkably, active processes begin prior to the onset of sensory experience, when neurons fire spontaneous periodic bursts of action potentials. This highly stereotyped, intrinsically generated activity promotes neuronal survival, maturation and initial refinement of their connections. In the auditory system, spontaneous activity arises within the cochlea prior to hearing onset. During this critical developmental stage, glia-like supporting cells that surround inner hair cells spontaneously release ATP, triggering a cascade of events that ultimately results in hair cell depolarization, glutamate release and bursts of activity in groups of auditory neurons that will ultimately process similar frequencies of sound. We used electrophysiological recordings in isolated cochleae and in vivo imaging of auditory neuron activity from pre-hearing mice to uncover the complex molecular steps used to activate hair cells before hearing onset and the macroscopic patterns of activity exhibited by auditory neurons before hearing begins. I will discuss how glial cells control hair cell activity to promote correlated activity of neurons and astrocytes in this developing sensory system.

 Jan 25, 2021 @ 4:00 p.m.

Host: Neuroscience Graduate Program

NSC 503 Seminars

Anjali Sinha & Allison Murphy - Ph.D. Candidates

 Feb 01, 2021 @ 4:00 p.m.

NSC 503 Seminars

Kate Andersh & Emily Przysinda - Ph.D. Candidates

 Feb 08, 2021 @ 4:00 p.m.

NSC 503 Seminars

Matthew Adusel & Jo Fritzinger - Ph.D. Candidates

 Feb 15, 2021 @ 4:00 p.m.

NSC 503 Seminars

Matthew Adusel & Jo Fritzinger - Ph.D. Candidates

 Feb 15, 2021 @ 4:00 p.m.

NSC 503 Seminars

Linh Le & Mike DuHain - Ph.D. Candidates

 Feb 22, 2021 @ 4:00 p.m.

NSC 503 Seminars

Sarah Yablonski & MaKenna Cealie - Ph.D. Candidates

 Mar 01, 2021 @ 4:00 p.m.

NSC 503 Seminars

Caitlin Sharp & Evan Newbold - Ph.D. Candidates

 Mar 15, 2021 @ 4:00 p.m.

NSC 503 Seminars

Bingyu Sun & John Gonzalez Amoretti - Ph.D. Candidates

 Mar 22, 2021 @ 4:00 p.m.

NSC 503 Seminars

Yanya Ding & Amy Bucklaew - Ph.D. Candidates

 Mar 29, 2021 @ 4:00 p.m.

NSC 503 Seminars

Victoria Popov & Maleelo Shamambo - Ph.D. Candidates

 Apr 05, 2021 @ 4:00 p.m.

NSC 503 Seminars

Ari Seldowitz & Bryan Crum - Ph.D. Candidates

 Apr 12, 2021 @ 4:00 p.m.

ADSE Guest Lecture

Natalia Vergara, Ph.D. - University of Colorado Anschutz Medical Campus
Department of Ophthalmology

 Apr 19, 2021 @ 4:00 p.m.

NSC 503 Seminars

Abigail Sawicki & Mike Giannetto - Ph.D. Candidates

 Apr 26, 2021 @ 4:00 p.m.

NSC 503 Seminars

Paige Nicklas & Dennisha King - Ph.D. Candidates

 May 03, 2021 @ 4:00 p.m.

NSC 503 Seminars

Yunpeng Pang - Ph.D. Candidate

 May 10, 2021 @ 4:00 p.m.