News

NGP Student Publishes First-Author Paper in Analytical Biochemistry

Friday, January 24, 2020

Congratulations to Jake Rudlong, NGP student, for his first author review!

Rudlong J, Cheng A, Johnson GVW (2019 Dec 19). The role of transglutaminase 2 in mediating glial cell function and pathophysiology in the central nervous system. Analytical Biochemistry.

Two NGP Students First Author Nature Paper on Alzheimer's Disease

Thursday, January 23, 2020

Udaysankar Chockanathan and Emily J. Warner are the lead authors on the paper, "Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease" published in the journal Nature.

Abstract:  While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer’s disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population’s coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.

Excellent work Uday and Emily!