Press Releases & Research Commentary
October 5, 2016
More than $4.5 million in new grants to the lab of University of Rochester Medical Center scientist Maiken Nedergaard, M.D., D.M.Sc., underscore the important role the brain's waste disposal system may play in a range of neurological disorders. The new awards will advance understanding of how small vessel disease and traumatic brain injury can give rise to cognitive and behavioral problems.
Nedergaard and her colleagues first unveiled the brain's unique method of removing waste – dubbed the glymphatic system – in a paper in Science Translational Medicine in 2012. The research revealed that the brain possesses a circulation network that piggybacks on blood vessels and uses cerebral spinal fluid to flush away waste products from brain tissue. Since that time, the team has gone on to show that the glymphatic system works primarily while we sleep, could be a key player in diseases like Alzheimer's, and is disrupted after traumatic brain injury.
August 8, 2016
New research in the journal Neuron reveals how the brain is able to meet its massive energy demands with a
just in timesystem that delivers oxygen that fuels nerve cells. The findings could shed light on diseases like Alzheimer's and help explain the cognitive decline that accompanies the disease.
Our brains require a tremendous amount of energy and in order to meet this demand the flow of blood must be precisely choreographed to ensure that oxygen is being delivered where it is needed and when it is needed,said Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study.
This study demonstrates that microvessels in the brain play a key role in reacting to spikes in demand and accelerating the flow of blood to respond to neuronal activity.
June 30, 2016
Sleep is critical for rest and rejuvenation. A human being will actually die of sleep deprivation before starvation--it takes about two weeks to starve, but only 10 days to die if you go without sleep.
The CDC has also classified insufficient sleep as a public health concern. Those who don't get enough sleep are more likely to suffer from chronic diseases that include hypertension, diabetes, depression, obesity, and cancer.
It's thus vital to get enough shuteye, but it turns out your sleep position also has a significant impact on the quality of rest you get.
Now, a neuroscience study suggests that of all sleep positions, one is most helpful when it comes to efficiently cleaning out waste from the brain: sleeping on your side.
The study, published in the Journal of Neuroscience, used dynamic contrast-enhanced MRI to image the brain's "glymphatic pathway." This is the system by which cerebrospinal fluid filters through the brain and swaps with interstitial fluid (the fluid around all other cells in the body).
"It is interesting that the lateral [side] sleep position is already the most popular in humans and most animals--even in the wild," said University of Rochester's Maiken Nedergaard. "It appears that we have adapted the lateral sleep position to most efficiently clear our brain of the metabolic waste products that build up while we are awake."
April 29, 2016
A study out today in the journal Science sheds new light on the biological mechanisms that control the sleep-wake cycle. Specifically, it shows that a simple shift in the balance of chemicals found in the fluid that bathes and surrounds brain cells can alter the state of consciousness of animals.
The study, which focuses on a collection of ions that reside in the cerebral spinal fluid (CSF), found that not only do these changes play a key role in stimulating or dampening the activity of nerve cells, but they also appear to alter cell volume causing brain cells to shrink while we sleep, a process that facilitates the removal of waste.
Understanding what drives arousal is essential to deciphering consciousness and the lack thereof during sleep,said Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study.
We found that the transition from wakefulness to sleep is accompanied by a marked and sustained change in the concentration of key extracellular ions and the volume of the extracellular space.
The current scientific consensus is that the brain is
woken upby a set of neurotransmitters – which include compounds such as acetylcholine, hypocretin, histamine, serotonin, noradrenaline, and dopamine – that originate from structures deep within the brain and the brain stem. This cocktail of chemical messengers serve to activate – or arouse – a set of neurons in the cerebral cortex and other parts of the brain responsible for memory, thinking, and learning, placing the brain in a state of wakefulness.
January 11, 2016
New research shows that the cells responsible for protecting the brain from infection and inflammation are also responsible for repairing the system of defenses that separates the brain from the rest of the body. These findings have significant clinical implications because certain cardiovascular drugs could possibly impede the brain's ability to repair itself after a stroke or other injury.
This study shows that the resident immune cells of the central nervous system play a critical and previously unappreciated role in maintaining the integrity of the blood-brain barrier,said Maiken Nedergaard, M.D., D.M.Sc., co-director of the Center for Translational Neuromedicine at the University of Rochester Medical Center (URMC) and lead author of the study.
When this barrier is breached it must be rapidly repaired in order to maintain the health of the brain and aid in recovery after an injury – a process that could be impaired by drugs that are intended to prevent this damage in the first place.
- NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.Brain Struct Funct. (2016 Sep 01).
- Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.Neurobiol Dis. 93, 215-25. (2016 Sep 01).
- Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.J Cereb Blood Flow Metab. 36, 1537-52. (2016 Sep 01).