URMC / Labs / Awad Lab / Publications Recent Publications Kenney HMChen KLSchnur LFox JIWood RWXing LRitchlin CTRahimi HSchwarz EMAwad HA High-throughput micro-CT analysis identifies sex-dependent biomarkers of erosive arthritis in TNF-Tg mice and differential response to anti-TNF therapy.; PloS one; Vol 19(7), pp. e0305623. 2024 Jul 05. Lee WTecle NKnapp EAwad HOh I Biomechanical Effects of Subtalar Joint Fusion and Medial Ligament Reconstruction in Simulated Progressive Collapsing Foot Deformity.; Foot & ankle international. 2024 Jan 19. Awad HAjalik RAlenchery RLinares IWright TMiller BMcGrath J Human tendon-on-a-chip for modeling vascular inflammatory fibrosis.; Research square. 2023 Dec 13. Little DAmadio PCAwad HCone SGDyment NAFisher MBHuang AHKoch DWKuntz AFMadi RMcGilvrey KSchnabel LVShetye SSThomopoulos SZhao CSoslowsky LJ Preclinical Tendon and Ligament Models: Beyond the 3Rs (Replacement, Reduction, and Refinement) to 5W1H (Why, Who, What, Where, When, How).; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Aug 12. Lake SPSnedeker JGWang VMAwad HScreen HRCThomopoulos S Guidelines for ex vivo mechanical testing of tendon.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jun 13. Alenchery RGAjalik REJerreld KMidekksa FZhong SAlkatib BAwad HA PAI-1 mediates TGF-β1 induced myofibroblast activation in tenocytes via mTOR signaling.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 May 04. Kaplan NBBarra MFJubril AKnapp EAwad HGinnetti J Effects of Acetabular Screws on the Initial Stability of Porous Coated Acetabular Implants in Revision Total Hip Arthroplasty.; Cureus; Vol 15(4), pp. e38257. 2023 Apr 28. Sautchuk RYu CMcArthur MMassie CBrookes PSPorter GAAwad HEliseev RA ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2023 Feb 13. Massie CKnapp EAwad HABerger AJ Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones.; Journal of biomechanics; Vol 161, pp. 111852. 2023 Jan 25. Kenney HMPeng YChen KLAjalik RSchnur LWood RWSchwarz EMAwad HA A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets.; Bone reports; Vol 16. 2022 Jun. Sautchuk RKalicharan BHEscalera-Rivera KJonason JHPorter GAAwad HAEliseev RA Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation.; eLife; Vol 11. 2022 May 30. Ramsdale EMohamed MYu VOtto EJuba KAwad HMoorthi KPlumb SPatil AVogelzang NDib EMohile S Polypharmacy, Potentially Inappropriate Medications, and Drug-Drug Interactions in Vulnerable Older Adults With Advanced Cancer Initiating Cancer Treatment.; The oncologist. 2022 Mar 28. Kallenbach JGFreeberg MATAbplanalp DAlenchery RGAjalik REMuscat SMyers JAAshton JMLoiselle ABuckley MRvan Wijnen AJAwad HA Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.; Scientific reports; Vol 12(1). 2022 Feb 22. McCloskey MCZhang VZAhmad SDWalker SRomanick SSAwad HAMcGrath JL Sourcing cells for in vitro models of human vascular barriers of inflammation.; Frontiers in medical technology; Vol 4, pp. 979768. 2022 Jan 21. Knapp EAwad HA Cantilever Bending of Murine Femoral Necks.; Journal of visualized experiments : JoVE. 2022 Jan 05. Young MWalsh DJMasters EGondil VSLaskey EKlaczko MAwad HMcGrath JSchwarz EMMelander CDunman PM Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors.; Antibiotics (Basel, Switzerland); Vol 11(10). 2022 Jan 04. Ajalik REAlenchery RGCognetti JSZhang VZMcGrath JLMiller BLAwad HA Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery.; Frontiers in bioengineering and biotechnology; Vol 10. 2022. Chen KMassie CAwad HABerger AJ Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands.; Biomedical optics express; Vol 12(12). 2021 Dec 01. Greenstein ASChen REBrown AMKnapp ERoberts AAwad HAVoloshin I Chondral Damage After Arthroscopic Repair Techniques for Acute Bony Bankart Lesions: A Biomechanical Study.; The American journal of sports medicine. 2021 Jul 08. Greenstein ASChen REKnapp EBrown AMRoberts AAwad HAVoloshin I A Biomechanical, Cadaveric Evaluation of Single- Versus Double-Row Repair Techniques on Stability of Bony Bankart Lesions.; The American journal of sports medicine. 2021 Feb 05. Massie CKnapp EChen KBerger AJAwad HA Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy.; Journal of biomechanics; Vol 116. 2021 Jan 13. Trombetta RPKnapp EKAwad HA A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutes.; Methods in molecular biology (Clifton, N.J.); Vol 2230. 2021. Masters EAMuthukrishnan GHo LGill ALde Mesy Bentley KLGalloway CAMcGrath JLAwad HAGill SRSchwarz EM Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis.; Frontiers in microbiology; Vol 12. 2021. Best KTNichols AECKnapp EHammert WCKetonis CJonason JHAwad HALoiselle AE NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.; Science signaling; Vol 13(658). 2020 Nov 17. Masters EAde Mesy Bentley KLGill ALHao SPGalloway CASalminen ATGuy DRMcGrath JLAwad HAGill SRSchwarz EM Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.; PLoS pathogens; Vol 16(10). 2020 Oct 22. Hollenberg AMSmith COShum LCAwad HEliseev RA Lactate Dehydrogenase Inhibition with Oxamate Exerts Bone Anabolic Effect.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020 Jul 30. Dyment NABarrett JGAwad HABautista CABanes AJButler DL A brief history of tendon and ligament bioreactors: Impact and future prospects.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Jun 24. MacDonald ACiufo DVess EKnapp EAwad HAKetz JPFlemister ASOh I Peritalar Kinematics With Combined Deltoid-Spring Ligament Reconstruction in Simulated Advanced Adult Acquired Flatfoot Deformity.; Foot & ankle international. 2020 Jun 04. Best KTStudentsova VAckerman JENichols AECMyers MCobb JKnapp EAwad HALoiselle AE Effects of Tamoxifen on Tendon Homeostasis and Healing: Considerations for the use of Tamoxifen-Inducible Mouse Models.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Jun 02. Pelled GLieber RAvalos PCohn-Yakubovich DTawackoli WRoth JKnapp ESchwarz EMAwad HAGazit DGazit Z Teriparatide (rPTH1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy.; Journal of tissue engineering and regenerative medicine. 2020 Jun 01. Vokes JObudzinski SKnapp EO'Malley SAwad HO'Malley N The Effects of Splitting an Above Elbow Cast: A biomechanical study.; Injury. 2020 May 23. Shares BHSmith COSheu TJSautchuk RSchilling KShum LCPaine AHuber AGira EBrown EAwad HEliseev RA Inhibition of the mitochondrial permeability transition improves bone fracture repair.; Bone. 2020 Apr 28. O'Keefe RJTuan RSLane NEAwad HABarry FBunnell BAColnot CDrake MTDrissi HDyment NAFortier LAGuldberg REKandel RLittle DGMarshall MFMao JJNakamura NProffen BLRodeo SARosen VThomopoulos SSchwarz EMSerra R American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 38(3). 2020 Mar. Chen RESoin SPEl-Shaar RNicandri GTAwad HAMaloney MDVoloshin I What Regions of the Distal Clavicle Have the Greatest Bone Mineral Density and Cortical Thickness? A Cadaveric Study.; Clinical orthopaedics and related research; Vol 477(12). 2019 Dec. O'Keefe RJTuan RSLane NEBarry FBunnell BAColnot CDrake MTDrissi HFortier LAGuldberg RELittle DGMarshall MFMao JJNakamura NRobey PGRosen VRowe DWSchwarz EM American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2019 Sep 23. Chen RESoin SPEl-Shaar RNicandri GTAwad HAMaloney MDVoloshin I What Regions of the Distal Clavicle Have the Greatest Bone Mineral Density and Cortical Thickness? A Cadaveric Study.; Clinical orthopaedics and related research. 2019 Aug 29. Freeberg MATEasa ALillis JABenoit DSWvan Wijnen AJAwad HA Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2019 Aug 19. Best KTLee FKKnapp EAwad HALoiselle AE Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing.; Scientific reports; Vol 9(1). 2019 Jul 29. Trombetta RPde Mesy Bentley KLSchwarz EMKate SLAwad HA A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis.; European cells & materials; Vol 37. 2019 Jun 27. Masters EASalminen ATBegolo SLuke ENBarrett SOverby CTGill ALde Mesy Bentley KLAwad HAGill SRSchwarz EMMcGrath JL An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis.; Nanomedicine : nanotechnology, biology, and medicine. 2019 Jun 24. Feigenson MJonason JHShen JLoiselle AEAwad HAO'Keefe RJ Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.; Annals of biomedical engineering. 2019 Apr 12. Trombetta RPNinomiya MJEl-Atawneh IMKnapp EKde Mesy Bentley KLDunman PMSchwarz EMKates SLAwad HA Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.; Pharmaceutics; Vol 11(2). 2019 Feb 22. Chen RESoin SPEl-Shaar RAwad HAMaloney MDVoloshin I Reconstruction of the Superior Glenoid Labrum With Biceps Tendon Autograft: A Cadaveric Biomechanical Study.; Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association; Vol 35(2). 2019 Feb. Masters EATrombetta RPde Mesy Bentley KLBoyce BFGill ALGill SRNishitani KIshikawa MMorita YIto HBello-Irizarry SNNinomiya MBrodell JDLee CCHao SPOh IXie CAwad HADaiss JLOwen JRKates SLSchwarz EMMuthukrishnan G Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".; Bone research; Vol 7. 2019. Trombetta RPDunman PMSchwarz EMKates SLAwad HA A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.; mSphere; Vol 3(5). 2018 Oct 31. Shu CChen KLynch MMaher JRAwad HABerger AJ Spatially offset Raman spectroscopy for in vivo bone strength prediction.; Biomedical optics express; Vol 9(10). 2018 Oct 01. Childs SMcVicker ZTrombetta RAwad HElfar JGiordano B Patient-Specific 3-Dimensional Modeling and Its Use for Preoperative Counseling of Patients Undergoing Hip Arthroscopy.; Orthopaedic journal of sports medicine; Vol 6(9). 2018 Sep. Schott EMFarnsworth CWGrier ALillis JASoniwala SDadourian GHBell RDDoolittle MLVillani DAAwad HKetz JPKamal FAckert-Bicknell CAshton JMGill SRMooney RAZuscik MJ Targeting the gut microbiome to treat the osteoarthritis of obesity.; JCI insight; Vol 3(8). 2018 Apr 19. Freeberg MATFarhat YMEasa AKallenbach JGMalcolm DWBuckley MRBenoit DSWAwad HA Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.; Scientific reports; Vol 8(1). 2018 Apr 11. Yukata KXie CLi TFBrown MLKanchiku TZhang XAwad HASchwarz EMBeck CAJonason JHO'Keefe RJ Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice.; Bone. 2018 Feb 02.