URMC / Labs / Awad Lab / Publications Recent Publications Bez MSheyn DTawackoli WAvalos PShapiro GGiaconi JCDa XDavid SBGavrity JAwad HABae HWLey EJKremen TJGazit ZFerrara KWPelled GGazit D (2017 May 17). In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Science translational medicine. Beier EESheu TJResseguie EATakahata MAwad HACory-Slechta DAPuzas JE (2017). Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice. Bone research. Trombetta RInzana JASchwarz EMKates SLAwad HA (2016 Jun 20). 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery. Annals of biomedical engineering. Inzana JASchwarz EMKates SLAwad HA (2016 Mar). Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials. Yaseen ZEnglish CStanbury SJChen TMessing SAwad HElfar JC (2015 Jul). The Effect of the Epitendinous Suture on Gliding in a Cadaveric Model of Zone II Flexor Tendon Repair. The Journal of hand surgery. Loiselle AEYukata KGeary MBKondabolu SShi SJonason JHAwad HAO'Keefe RJ (2015 Jun). Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Wang CShen JYukata KInzana JAO'Keefe RJAwad HAHilton MJ (2015 Apr). Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone. Geary MBEnglish CYaseen ZStanbury SAwad HElfar JC (2015 Apr). Flexor digitorum superficialis repair outside the A2 pulley after zone II laceration: gliding and bowstringing. The Journal of hand surgery. Zhang MFeigenson MSheu TJAwad HASchwarz EMJonason JHLoiselle AEO'Keefe RJ (2015 Mar). Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone. Inzana JASchwarz EMKates SLAwad HA (2015 Mar). A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone. Farhat YMAl-Maliki AAEasa AO'Keefe RJSchwarz EMAwad HA (2015 Feb). TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair. Journal of cellular physiology. Lee DJSouthgate RDFarhat YMLoiselle AEHammert WCAwad HAO'Keefe RJ (2015 Jan). Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Geary MBOrner CABawany FAwad HAHammert WCO'Keefe RJLoiselle AE (2015). Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair. PloS one. Inzana JATrombetta RPSchwarz EMKates SLAwad HA (2015). 3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection. European cells & materials. Yukata KXie CLi TFTakahata MHoak DKondabolu SZhang XAwad HASchwarz EMBeck CAJonason JHO'Keefe RJ (2014 May). Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone. Inzana JAOlvera DFuller SMKelly JPGraeve OASchwarz EMKates SLAwad HA (2014 Apr). 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials. Long TZhu ZAwad HASchwarz EMHilton MJDong Y (2014 Mar). The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice. Biomaterials. Stanbury SJEnglish CYaseen ZReed JDChen TAwad HElfar JC (2014 Mar). The Effect of Pulley Reconstruction on Maximum Flexion, Bowstringing, and Gliding Coefficient in the Setting of Zone II Repair of FDS and FDP: a Cadaveric Investigation. Hand (New York, N.Y.). Juneja SCVonica AZeiss CLezon-Geyda KYatsula BSell DRMonnier VMLin SArdito TEyre DReynolds DYao ZAwad HAYu HWilson MHonnons SBoyce BFXing LZhang YPerkins AS (2014 Mar). Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone. David MAJones KHInzana JAZuscik MJAwad HAMooney RA (2014). Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes. PloS one. Brown MLYukata KFarnsworth CWChen DGAwad HHilton MJO'Keefe RJXing LMooney RAZuscik MJ (2014). Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. PloS one. Hasslund SDadali TUlrich-Vinther MSøballe KSchwarz EMAwad HA (2014). Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions. Journal of tissue engineering. Chaubey AGrawe BMeganck JADyment NInzana JJiang XConnolley CAwad HRowe DKenter KGoldstein SAButler D (2013 Dec). Structural and biomechanical responses of osseous healing: a novel murine nonunion model. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology. Inzana JAKung MShu LHamada DXing LPZuscik MJAwad HAMooney RA (2013 Nov). Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone. Maher JRInzana JAAwad HABerger AJ (2013 Jul). Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones. Journal of biomedical optics. Chu JYChen TAwad HAElfar JHammert WC (2013 Jun). Comparison of an all-inside suture technique with traditional pull-out suture and suture anchor repair techniques for flexor digitorum profundus attachment to bone. The Journal of hand surgery. Madsen WYaseen ZLaFrance RChen TAwad HMaloney MVoloshin I (2013 Jun). Addition of a suture anchor for coracoclavicular fixation to a superior locking plate improves stability of type IIB distal clavicle fractures. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. Chen THilton MJBrown EBZuscik MJAwad HA (2013 May). Engineering superficial zone features in tissue engineered cartilage. Biotechnology and bioengineering. Dhillon RSXie CTyler WCalvi LMAwad HAZuscik MJO'Keefe RJSchwarz EM (2013 Mar). PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Inzana JAMaher JRTakahata MSchwarz EMBerger AJAwad HA (2013 Feb 22). Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis. Journal of biomechanics. Juneja SCSchwarz EMO'Keefe RJAwad HA (2013). Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis. Connective tissue research. Takahata MMaher JRJuneja SCInzana JXing LSchwarz EMBerger AJAwad HA (2012 Nov). Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis and rheumatism. Chen TBuckley MCohen IBonassar LAwad HA (2012 May). Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels. Biomechanics and modeling in mechanobiology. Takahata MAwad HAO'Keefe RJBukata SVSchwarz EM (2012 Mar). Endogenous tissue engineering: PTH therapy for skeletal repair. Cell and tissue research. Takahata MSchwarz EMChen TO'Keefe RJAwad HA (2012 Jan). Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Loiselle AEFrisch BJWolenski MJacobson JACalvi LMSchwarz EMAwad HAO'Keefe RJ (2012). Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. PloS one. Farhat YMAl-Maliki AAChen TJuneja SCSchwarz EMO'Keefe RJAwad HA (2012). Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing. PloS one. Zhao LHuang JZhang HWang YMatesic LETakahata MAwad HChen DXing L (2011 Oct). Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem cells (Dayton, Ohio). Sampson ERHilton MJTian YChen DSchwarz EMMooney RABukata SVO'Keefe RJAwad HPuzas JERosier RNZuscik MJ (2011 Sep 21). Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Science translational medicine. Papuga MOKwok EYou ZRubery PTDougherty PEPryhuber GBeck CAHilton MJAwad HASchwarz EM (2011 Sep). TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Yazici CTakahata MReynolds DGXie CSamulski RJSamulski JBeecham EJGertzman AASpilker MZhang XO'Keefe RJAwad HASchwarz EM (2011 Aug). Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Molecular therapy : the journal of the American Society of Gene Therapy. Maher JRTakahata MAwad HABerger AJ (2011 Aug). Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. Journal of biomedical optics. Sampson ERBeck CAKetz JCanary KLHilton MJAwad HSchwarz EMChen DO'Keefe RJRosier RNZuscik MJ (2011 Aug). Establishment of an index with increased sensitivity for assessing murine arthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Yee MWhite RJAwad HABates WAMcGrath-Morrow SAO'Reilly MA (2011 Jun). Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice. The American journal of pathology. Katzel EBKoltz PFTierney RWilliams JPAwad HAO'keefe RJLangstein HN (2011 Jun). The impact of Smad3 loss of function on TGF-β signaling and radiation-induced capsular contracture. Plastic and reconstructive surgery. Katzel EBWolenski MLoiselle AEBasile PFlick LMLangstein HNHilton MJAwad HAHammert WCO'Keefe RJ (2011 May). Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Zhang MHo HCSheu TJBreyer MDFlick LMJonason JHAwad HASchwarz EMO'Keefe RJ (2011 Apr). EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Reynolds DGTakahata MLerner ALO'Keefe RJSchwarz EMAwad HA (2011 Mar 1). Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. Bone. Jacobson JAYanoso-Scholl LReynolds DGDadali TBradica GBukata SPuzas EJZuscik MJRosier RO'Keefe RJSchwarz EMAwad HA (2011 Feb). Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue engineering. Part A. Yanoso-Scholl LJacobson JABradica GLerner ALO'Keefe RJSchwarz EMZuscik MJAwad HA (2010 Dec 1). Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. Journal of biomedical materials research. Part A.