URMC / Labs / Awad Lab / Publications Recent Publications Trombetta RPDunman PMSchwarz EMKates SLAwad HA A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.; mSphere; Vol 3(5). 2018 Oct 31. Childs SMcVicker ZTrombetta RAwad HElfar JGiordano B Patient-Specific 3-Dimensional Modeling and Its Use for Preoperative Counseling of Patients Undergoing Hip Arthroscopy.; Orthopaedic journal of sports medicine; Vol 6(9). 2018 Sep. Schott EMFarnsworth CWGrier ALillis JASoniwala SDadourian GHBell RDDoolittle MLVillani DAAwad HKetz JPKamal FAckert-Bicknell CAshton JMGill SRMooney RAZuscik MJ Targeting the gut microbiome to treat the osteoarthritis of obesity.; JCI insight; Vol 3(8). 2018 Apr 19. Freeberg MATFarhat YMEasa AKallenbach JGMalcolm DWBuckley MRBenoit DSWAwad HA Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.; Scientific reports; Vol 8(1). 2018 Apr 11. Bez MSheyn DTawackoli WAvalos PShapiro GGiaconi JCDa XDavid SBGavrity JAwad HABae HWLey EJKremen TJGazit ZFerrara KWPelled GGazit D In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs.; Science translational medicine; Vol 9(390). 2017 May 17. Feng GOchoa MMaher JRAwad HABerger AJ Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.; Journal of biophotonics. 2017 May 02. Beier EESheu TJResseguie EATakahata MAwad HACory-Slechta DAPuzas JE Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.; Bone research; Vol 5. 2017. de Mesy Bentley KLTrombetta RNishitani KBello-Irizarry SNNinomiya MZhang LChung HLMcGrath JLDaiss JLAwad HAKates SLSchwarz EM Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 Dec 08. Trombetta RInzana JASchwarz EMKates SLAwad HA 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.; Annals of biomedical engineering. 2016 Jun 20. Inzana JASchwarz EMKates SLAwad HA Biomaterials approaches to treating implant-associated osteomyelitis.; Biomaterials; Vol 81. 2016 Mar. Yaseen ZEnglish CStanbury SJChen TMessing SAwad HElfar JC The Effect of the Epitendinous Suture on Gliding in a Cadaveric Model of Zone II Flexor Tendon Repair.; The Journal of hand surgery; Vol 40(7). 2015 Jul. Loiselle AEYukata KGeary MBKondabolu SShi SJonason JHAwad HAO'Keefe RJ Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 33(6). 2015 Jun. Wang CShen JYukata KInzana JAO'Keefe RJAwad HAHilton MJ Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.; Bone; Vol 73. 2015 Apr. Geary MBEnglish CYaseen ZStanbury SAwad HElfar JC Flexor digitorum superficialis repair outside the A2 pulley after zone II laceration: gliding and bowstringing.; The Journal of hand surgery; Vol 40(4). 2015 Apr. Zhang MFeigenson MSheu TJAwad HASchwarz EMJonason JHLoiselle AEO'Keefe RJ Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.; Bone; Vol 72. 2015 Mar. Inzana JASchwarz EMKates SLAwad HA A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery.; Bone; Vol 72. 2015 Mar. Farhat YMAl-Maliki AAEasa AO'Keefe RJSchwarz EMAwad HA TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.; Journal of cellular physiology; Vol 230(2). 2015 Feb. Lee DJSouthgate RDFarhat YMLoiselle AEHammert WCAwad HAO'Keefe RJ Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 33(1). 2015 Jan. Geary MBOrner CABawany FAwad HAHammert WCO'Keefe RJLoiselle AE Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.; PloS one; Vol 10(8). 2015. Inzana JATrombetta RPSchwarz EMKates SLAwad HA 3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection.; European cells & materials; Vol 30. 2015. Yukata KXie CLi TFTakahata MHoak DKondabolu SZhang XAwad HASchwarz EMBeck CAJonason JHO'Keefe RJ Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.; Bone; Vol 62. 2014 May. Inzana JAOlvera DFuller SMKelly JPGraeve OASchwarz EMKates SLAwad HA 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration.; Biomaterials; Vol 35(13). 2014 Apr. Long TZhu ZAwad HASchwarz EMHilton MJDong Y The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.; Biomaterials; Vol 35(9). 2014 Mar. Stanbury SJEnglish CYaseen ZReed JDChen TAwad HElfar JC The Effect of Pulley Reconstruction on Maximum Flexion, Bowstringing, and Gliding Coefficient in the Setting of Zone II Repair of FDS and FDP: a Cadaveric Investigation.; Hand (New York, N.Y.); Vol 9(1). 2014 Mar. Juneja SCVonica AZeiss CLezon-Geyda KYatsula BSell DRMonnier VMLin SArdito TEyre DReynolds DYao ZAwad HAYu HWilson MHonnons SBoyce BFXing LZhang YPerkins AS Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.; Bone; Vol 60. 2014 Mar. David MAJones KHInzana JAZuscik MJAwad HAMooney RA Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes.; PloS one; Vol 9(3). 2014. Brown MLYukata KFarnsworth CWChen DGAwad HHilton MJO'Keefe RJXing LMooney RAZuscik MJ Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.; PloS one; Vol 9(6). 2014. Hasslund SDadali TUlrich-Vinther MSøballe KSchwarz EMAwad HA Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions.; Journal of tissue engineering; Vol 5. 2014. Hasslund SO'Keefe RJAwad HA A mouse model of flexor tendon repair.; Methods in molecular biology (Clifton, N.J.); Vol 1130. 2014. Chaubey AGrawe BMeganck JADyment NInzana JJiang XConnolley CAwad HRowe DKenter KGoldstein SAButler D Structural and biomechanical responses of osseous healing: a novel murine nonunion model.; Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology; Vol 14(4). 2013 Dec. Inzana JAKung MShu LHamada DXing LPZuscik MJAwad HAMooney RA Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur.; Bone; Vol 57(1). 2013 Nov. Maher JRInzana JAAwad HABerger AJ Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones.; Journal of biomedical optics; Vol 18(7). 2013 Jul. Chu JYChen TAwad HAElfar JHammert WC Comparison of an all-inside suture technique with traditional pull-out suture and suture anchor repair techniques for flexor digitorum profundus attachment to bone.; The Journal of hand surgery; Vol 38(6). 2013 Jun. Madsen WYaseen ZLaFrance RChen TAwad HMaloney MVoloshin I Addition of a suture anchor for coracoclavicular fixation to a superior locking plate improves stability of type IIB distal clavicle fractures.; Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association; Vol 29(6). 2013 Jun. Chen THilton MJBrown EBZuscik MJAwad HA Engineering superficial zone features in tissue engineered cartilage.; Biotechnology and bioengineering; Vol 110(5). 2013 May. Dhillon RSXie CTyler WCalvi LMAwad HAZuscik MJO'Keefe RJSchwarz EM PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 28(3). 2013 Mar. Inzana JAMaher JRTakahata MSchwarz EMBerger AJAwad HA Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis.; Journal of biomechanics; Vol 46(4). 2013 Feb 22. Juneja SCSchwarz EMO'Keefe RJAwad HA Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis.; Connective tissue research; Vol 54(3). 2013. Takahata MMaher JRJuneja SCInzana JXing LSchwarz EMBerger AJAwad HA Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk.; Arthritis and rheumatism; Vol 64(11). 2012 Nov. Chen TBuckley MCohen IBonassar LAwad HA Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels.; Biomechanics and modeling in mechanobiology; Vol 11(5). 2012 May. Takahata MAwad HAO'Keefe RJBukata SVSchwarz EM Endogenous tissue engineering: PTH therapy for skeletal repair.; Cell and tissue research; Vol 347(3). 2012 Mar. Takahata MSchwarz EMChen TO'Keefe RJAwad HA Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 27(1). 2012 Jan. Loiselle AEFrisch BJWolenski MJacobson JACalvi LMSchwarz EMAwad HAO'Keefe RJ Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.; PloS one; Vol 7(7). 2012. Farhat YMAl-Maliki AAChen TJuneja SCSchwarz EMO'Keefe RJAwad HA Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing.; PloS one; Vol 7(12). 2012. Zhao LHuang JZhang HWang YMatesic LETakahata MAwad HChen DXing L Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1.; Stem cells (Dayton, Ohio); Vol 29(10). 2011 Oct. Sampson ERHilton MJTian YChen DSchwarz EMMooney RABukata SVO'Keefe RJAwad HPuzas JERosier RNZuscik MJ Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.; Science translational medicine; Vol 3(101). 2011 Sep 21. Papuga MOKwok EYou ZRubery PTDougherty PEPryhuber GBeck CAHilton MJAwad HASchwarz EM TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 29(9). 2011 Sep. Yazici CTakahata MReynolds DGXie CSamulski RJSamulski JBeecham EJGertzman AASpilker MZhang XO'Keefe RJAwad HASchwarz EM Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 19(8). 2011 Aug. Maher JRTakahata MAwad HABerger AJ Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis.; Journal of biomedical optics; Vol 16(8). 2011 Aug. Sampson ERBeck CAKetz JCanary KLHilton MJAwad HSchwarz EMChen DO'Keefe RJRosier RNZuscik MJ Establishment of an index with increased sensitivity for assessing murine arthritis.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 29(8). 2011 Aug.