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Research

Spotlight on our Faculty Researchers

Ilan Goldenberg, M.D.

Ilan Goldenberg, MDDr. Goldenberg has been involved in clinical research with cardiac arrhythmias over the past 15 years and published by over 500 papers. He has been serving as PI on more than 50 government supported international clinical trials and registries and industry supported clinical studies and trials. Accordingly, Dr. Goldenberg has substantial experience in clinical trials conduct, organization, design, and data analysis. Over the past 14 years he has been involved in the design and conduction of multicenter clinical trials, collaborating with the Heart Research Follow-Up Program at the University of Rochester and serving at the Director of the Israeli Association for Cardiovascular Trials. In his current position he serves as the Director of the Clinical Cardiovascular Research Center at the University of Rochester, organizing multicenter trials and the International LQTS Registry, with his active role in the CC and DCC capacities. He also has mentored more than 100 trainees, including medical students, residents and fellows, and PhD applicants.

Valentina Kutyifa, M.D., Ph.D.

Valentina Kutyifa, MD, PhDDr. Valentina Kutyifa holds an MD degree, a PhD in cardiac electrophysiology, a Masters degree in health care management, and a certificate in clinical research from Harvard Medical School, and performs research in cardiac arrhythmias, diabetes, heart failure, and sudden cardiac death. Her research work encompasses a wide array of studies related to diabetes, implantable cardioverter–defibrillators, cardiac resynchronization therapy, echocardiography, and technology innovations including the wearable cardioverter–defibrillator, subcutaneous ICD, and left ventricular assist devices.

Peter Bleszynski, M.D

 

 

 

 

The Cardiology Division offers a wide range of research projects to our fellows. We have outstanding clinical research opportunities. We are the home to the world's most successful sudden death arrhythmia research group, the Heart Research Follow-up Program. This research team leads the MADIT series of trials and other leading clinical studies in devices which treat lethal arrhythmias and conduction system defects.

The Cardiology Division also offers basic research within the Aab Cardiovascular Research Institute (CVRI). A wide range of basic science projects are available at the CVRI, including research into vascular biology, heart failure, and ion channels. The CVRI also is home to the URMC Howard Hughes Medical Institute (HHMI) Med-into-Grad Graduate Program for translational biomedical research.

View our Division research pages.

Research Spotlight: Zaid Al Jebaje, M.B.Ch.B.

Outcomes and Complications of Cardiac Resynchronization Therapy in Patients with Continuous-Flow Left Ventricular Assist Devices

May 3, 2022

Zaid Al Jebaje, M.B.Ch.B.The role of cardiac resynchronization therapy (CRT-D) in heart failure patients has been well established, so has the role of continuous-flow left ventricular assist device (CF-LVAD). But the effect of both therapies on clinical outcomes and complications in patients with CF-LVAD is currently not well understood.

The University of Rochester medical center is one of the largest LVAD implant centers in the nation and a leader in the field of electrophysiology devices. A recent study led by Dr. Zaid Al Jebaje showed that In CF-LVAD patients, CRT-D was not associated with improved survival. The study also showed that device-related complications were frequently observed in patients with CRT-D.

Our data suggest that continuing CRT-D therapy in CF-LVAD patients should be considered on an individual basis.” - Dr. Zaid Al Jebaje, M.B.Ch.B.

 

 

 

 

 

 

 

Dr. Al Jebaje is a 2022 University of Rochester Cardiovascular Disease Fellowship graduate who will be joining Henry Ford Health System in Detroit, MI. as an Interventional Cardiology Fellow. The abstract was presented at the Heart Rhythm Society annual meeting July-2021 and published in Heart Rhythm journal in August 2021, DOI: http://dx.doi.org/10.1016/j.hrthm.2021.06.132 

Fellow Research

2022

Godwin MD, Aggarwal A, Hilt Z, Shah S, Gorski J, Cameron SJ. Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals.  JACC Basic Transl Sci. 2021 Dec 8;7(1):14-25. doi: 10.1016/j.jacbts.2021.10.009. eCollection 2022 Jan. PMID: 35128205

2021

Naqvi SY, Joynt M, Prasad S,​ et al. Severe baffle leak after Takeuchi repair successfully treated with coronary bypass and percutaneous baffle closure: a case report. Eur Heart J Case Rep. 2021 Mar  Mar 21;5(3):ytab074. doi: 10.1093/ehjcr/ytab074.

Bleszynski, P, Schwartz, R. Optimizing patient centered care in the cardiac intensive care unit: Harness the safety, effectiveness, and incremental value of radionuclide perfusion, function, and molecular imaging. J. Nucl. Cardiol. 2021 Jun;Epub ahead of print. doi: 10.1007/s12350-021-02691-x.

Tankut S, Goldenberg I, Kutyifa V, Zareba W, Bragazzi NL, McNitt S, Huang DT, Aktas MK, Younis A. Cardiac Resynchronization Therapy and Ventricular Tachyarrhythmia Burden. Heart Rhythm. 2021 May;18(5):762-769. doi: 10.1016/j.hrthm.2020.12.034.

Goldenberg I, Younis A, Huang DT, Yoruk A, et al Use of oral contraceptives in women with congenital long QT syndrome. Heart Rhythm. 2021 Jul 30:S1547-5271(21)01987-1. doi: 10.1016/j.hrthm.2021.07.058. 

2020

Bleszynski P, Goldenberg I, Fernandez G, et al. Risk of Arrhythmic Events Following Alcohol Septal Ablation for Hypertrophic Cardiomyopathy Using Continuous Implantable Cardiac Monitoring. Heart Rhythm. 2021 Jan;18(1):50-56. doi:10.1016/j.hrthm.2020.08.013.

Riordan M, Opaskar A, Yoruk A, et al. Predictors of Atrial Fibrillation During Long-Term Implantable Cardiac Monitoring Following Cryptogenic Stroke. J Am Heart Assoc. 2020;9(15):e016040. doi:10.1161/JAHA.120.016040.

Lee EC, McNitt S, Martens J, et al. Long-term milrinone therapy as a bridge to heart transplantation: Safety, efficacy, and predictors of failure. Int J Cardiol. 2020;313:83-88. doi:10.1016/j.ijcard.2020.04.055.

Armenia EM, Schwartz RG. ISCHEMIA questions and MITNEC answers: Defining and standardizing clinical ischemic jeopardy with SPECT myocardial perfusion imaging J Nucl Cardiol. 2020; Epub ahead of print. doi:10.1007/s12350-020-02237-7.

Mahlof EN, Bisognano JD. Reducing cardiovascular risk caused by air pollution: individuals can make a difference.  J Hum Hypertens 2020 Dec;34(12):805-806. doi:10.1038/s41371-020-00404-4.

Lee EC, Goldenberg I, Vidula H. Response to "How to consider optimal therapeutic strategy for bridge to heart transplantation" Int J Cardiol. 2020 Dec 1;320:126. doi:10.1016/j.ijcard.2020.07.003.

Aktas M, Bennett AL, Younis A, et al. Implantable cardioverter-defibrillator programming after first occurrence of ventricular tachycardia in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Heart Rhythm O2. 2020 May 11;1(2):77-82. doi: 10.1016/j.hroo.2020.04.001.

Elbadawi A, Naqvi SY, Saad M, et al. In-Hospital Outcomes with Transfemoral Versus Transapical Access for Transcatheter Aortic Valve Replacement in Patients with Peripheral Arterial Disease. Cardiovasc Revasc Med. 2020;21(5):604-609. doi:10.1016/j.carrev.2019.09.009.

Chen YL, Wright C, Pietropaoli AP, et al. Right ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis. 2020;49(1):34-41. doi:10.1007/s11239-019-01922-w.

Vidula H, Lee E, McNitt S, et al. Cardiac Resynchronization Therapy and Risk of Recurrent Hospitalizations in Patients Without Left Bundle Branch Block: The Long-Term Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy. Circ Heart Fail. 2020;13(7):e006925. doi:10.1161/CIRCHEARTFAILURE.120.006925.

Kutyifa V, Naqvi SY, Vidula H, et al. Clinical Significance of Early Hospital Readmission in Continuous-Flow Left Ventricular Assist Device Patients. ASAIO J. 2020;66(7):760-765. doi:10.1097/MAT.0000000000001065.

Bisognano J, Bennett A. American Heart Association Hypertension Learning Guide Comprehensive Guide on Hypertension: Hypertensive Crisis. May 2020.

Bisognano J, Bennett A. American Heart Association Hypertension Learning Guide Comprehensive Guide on Hypertension: Coexisting Heart Disease. May 2020.

Kamran H, Hornacek D, Mix D, Wright C, Cameron SJ. A survey of commonly misunderstood vascular medicine physical exam findings among medical trainees. Vasc Med. 2020;25(4):351-353. doi:10.1177/1358863X20924100.

Van Galen J, Pava L, Wright C, et al. Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism [published online ahead of print, 2020 Mar 6]. Platelets. 2020;1-3. doi:10.1080/09537104.2020.1732329.

2019

Naqvi SY, Jawaid A, Vermilye K, et al. Left Ventricular Reverse Remodeling in Cardiac Resynchronization Therapy and Long-Term Outcomes. JACC Clin Electrophysiol. 2019;5(9):1001-1010. doi:10.1016/j.jacep.2019.07.012.

Seif E, Sherazi S, Bravo-Jaimes K, Cheyne C, Alexis JD. Driving Pulseless: A Driving Survey of Patients With Left Ventricular Assist Devices and Their Providers [published correction appears in J Card Fail. 2019 Jul;25(7):582]. J Card Fail. 2019;25(3):220-221. doi:10.1016/j.cardfail.2019.02.003

Wright C, Elbadawi A, Chen YL, et al. The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department. J Thromb Thrombolysis. 2019;48(2):331-335. doi:10.1007/s11239-019-01875-0.

Naqvi SY, Jain H, Prasad S, Stuver T. Management of Paravalvular Leak After Rapid Deployment Edwards Intuity Elite Valve. JACC Cardiovasc Interv. 2019;12(5):e39-e40. doi:10.1016/j.jcin.2018.12.023.

Naqvi SY, Wittlin SD, Schwartz RG. Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges. J Nucl Cardiol. 2019;26(4):1103-1106. doi:10.1007/s12350-017-1177-4.

Matsumoto C, Yoruk A, Wang L, Gaziano JM, Sesso HD. Fish and omega-3 fatty acid consumption and risk of hypertension. J Hypertens. 2019;37(6):1223-1229. doi:10.1097/HJH.0000000000002062.

Bishop GJ, Gorski J, Lachant D, Cameron SJ. Chronic thromboembolic pulmonary hypertension is a clot you cannot swat. J Vasc Surg Cases Innov Tech. 2019;5(4):402-405. Published 2019 Sep 17. doi:10.1016/j.jvscit.2019.07.004.

Ghisi GLM, Chaves GSDS, Bennett A, Lavie CJ, Grace SL. The Effects of Cardiac Rehabilitation on Mortality and Morbidity in Women: A META-ANALYSIS ATTEMPT. J Cardiopulm Rehabil Prev. 2019;39(1):39-42. doi:10.1097/HCR.0000000000000351.

Elbadawi A, Elgendy IY, Naqvi SY, et al. Temporal Trends and Outcomes of Hospitalizations With Prinzmetal Angina: Perspectives From a National Database. Am J Med. 2019;132(9):1053-1061.e1. doi:10.1016/j.amjmed.2019.04.005.

Elbadawi A, Naqvi SY, Elgendy IY, et al. Ethnic and Gender Disparities in the Uptake of Transcatheter Aortic Valve Replacement in the United States [published online ahead of print, 2019 Jun 25]. Cardiol Ther. 2019;8(2):151-155. doi:10.1007/s40119-019-0138-1.

2018

Yoruk A, Boulos PK, Bisognano JD. The State of Hypertension in Sub-Saharan Africa: Review and Commentary. Am J Hypertens. 2018;31(4):387-388. doi:10.1093/ajh/hpx196.

Jawaid A, Naqvi SY, Wiener R. Atrial myxoma presenting as acute ischaemic stroke and chronic right lower leg claudication. BMJ Case Rep. 2018;11(1):e227427. Published 2018 Dec 13. doi:10.1136/bcr-2018-227427.

Naqvi SY, Jawaid A, Goldenberg I, Kutyifa V. Non-response to Cardiac Resynchronization Therapy. Curr Heart Fail Rep. 2018;15(5):315-321. doi:10.1007/s11897-018-0407-7.

Naqvi SY, Salama IG, Yoruk A, Chen L. Ambulatory Intra Aortic Balloon Pump in Advanced Heart Failure. Card Fail Rev. 2018;4(1):43-45. doi:10.15420/cfr.2018:22:1.

Seif E, Chen L, Goldman B. MD. Fulminant Myocarditis; a review of the current literature. US Cardiology Review (USC) issue 12.1, 2018.

Naqvi SY, Wittlin SD, Schwartz RG. Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges. J Nucl Cardiol. 2019;26(4):1103-1106. doi:10.1007/s12350-017-1177-4.

Chong-Yik R, Bennett AL, Milani RV, Morin DP. Cost-Saving Opportunities with Appropriate Utilization of Cardiac Telemetry. Am J Cardiol. 2018;122(9):1570-1573. doi:10.1016/j.amjcard.2018.07.016.

Kutyifa V, Naqvi SY, Brown M, et al. Comparison of Long-Term Survival Benefits With Cardiac Resynchronization Therapy in Patients With Mild Heart Failure With Versus Without Diabetes Mellitus (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT]). Am J Cardiol. 2018;121(12):1567-1574. doi:10.1016/j.amjcard.2018.02.040.

Saha T, Naqvi SY, Goldberg S. Hybrid Revascularization: A Review. Cardiology. 2018;140(1):35-44. doi:10.1159/000488190.

Elbadawi A, Wright C, Patel D, et al. The impact of a multi-specialty team for high risk pulmonary embolism on resident and fellow education. Vasc Med. 2018;23(4):372-376. doi:10.1177/1358863X18767753.

Tafreshi S, Naqvi SY, Thomas S. Extra-adrenal pheochromocytoma presenting as inverse takotsubo-pattern cardiomyopathy treated with surgical resection. BMJ Case Rep. 2018;11(1):e226384. Published 2018 Dec 9. doi:10.1136/bcr-2018-226384.