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Research

Spotlight on our Faculty Researchers

Ilan Goldenberg, M.D.

Ilan Goldenberg, MDDr. Goldenberg has been involved in clinical research with cardiac arrhythmias over the past 15 years and published by over 500 papers. He has been serving as PI on more than 50 government supported international clinical trials and registries and industry supported clinical studies and trials. Accordingly, Dr. Goldenberg has substantial experience in clinical trials conduct, organization, design, and data analysis. Over the past 14 years he has been involved in the design and conduction of multicenter clinical trials, collaborating with the Heart Research Follow-Up Program at the University of Rochester and serving at the Director of the Israeli Association for Cardiovascular Trials. In his current position he serves as the Director of the Clinical Cardiovascular Research Center at the University of Rochester, organizing multicenter trials and the International LQTS Registry, with his active role in the CC and DCC capacities. He also has mentored more than 100 trainees, including medical students, residents and fellows, and PhD applicants.

Valentina Kutyifa, M.D., Ph.D.

Valentina Kutyifa, MD, PhDDr. Valentina Kutyifa holds an MD degree, a PhD in cardiac electrophysiology, a Masters degree in health care management, and a certificate in clinical research from Harvard Medical School, and performs research in cardiac arrhythmias, diabetes, heart failure, and sudden cardiac death. Her research work encompasses a wide array of studies related to diabetes, implantable cardioverter–defibrillators, cardiac resynchronization therapy, echocardiography, and technology innovations including the wearable cardioverter–defibrillator, subcutaneous ICD, and left ventricular assist devices.

The Cardiology Division offers a wide range of research projects to our fellows. We have outstanding clinical research opportunities. We are the home to the world's most successful sudden death arrhythmia research group, the Heart Research Follow-up Program. This research team leads the MADIT series of trials and other leading clinical studies in devices which treat lethal arrhythmias and conduction system defects.

The Cardiology Division also offers basic research within the Aab Cardiovascular Research Institute (CVRI). A wide range of basic science projects are available at the CVRI, including research into vascular biology, heart failure, and ion channels. The CVRI also is home to the URMC Howard Hughes Medical Institute (HHMI) Med-into-Grad Graduate Program for translational biomedical research.

View our Division research pages.

Research Spotlight

Cardiac Remodeling Means Improved Survival for Cardiomyopathy Patients

Friday, September 4, 2020

Jeffrey BruckelPatients implanted with cardiac resynchronization therapy have been shown to have improved clinical outcomes, and a more recent study led by Dr. Syed Naqvi now sheds further light on how left ventricular reverse remodeling might play a role in this process, according to a MADIT-CRT sub-study led by the University of Rochester Medical Center.

The study helps to improve our understanding benefits from this device during long-term follow-up, an unexplored area of research. We have seen that patients with LBBB, a common ECG abnormality in cardiomyopathy, CRT-D-induced reduction in LVESV at 1 year is associated with long-term survival benefit. But in patients without the presence of LBBB, there is no survival benefit and potential harm, despite left ventricular reverse remodeling with CRT-D, said Syed Naqvi, M.D., an Interventional Cardiology fellow and recent alumnus of the Cardiovascular Disease Fellowship Program, who led the research.

“These findings will guide clinicians and patients to make more informed decisions about the choice of the implanted device and its long-term benefits,” Naqvi said. “It’s very important to have early, frank, discussions around the goals of care.”

The study was published in JACC Clinical Electrophysiology in 2019 (see article in PubMed).

Fellow Research

2020

Bleszynski P, Goldenberg I, Fernandez G, et al. Risk of Arrhythmic Events Following Alcohol Septal Ablation for Hypertrophic Cardiomyopathy Using Continuous Implantable Cardiac Monitoring. Aug 24, 2020. Epub ahead of print. doi:10.1016/j.hrthm.2020.08.013

Riordan M, Opaskar A, Yoruk A, et al. Predictors of Atrial Fibrillation During Long-Term Implantable Cardiac Monitoring Following Cryptogenic Stroke. J Am Heart Assoc. 2020;9(15):e016040. doi:10.1161/JAHA.120.016040

Lee EC, McNitt S, Martens J, et al. Long-term milrinone therapy as a bridge to heart transplantation: Safety, efficacy, and predictors of failure. Int J Cardiol. 2020;313:83-88. doi:10.1016/j.ijcard.2020.04.055

Armenia EM, Schwartz RG. ISCHEMIA questions and MITNEC answers: Defining and standardizing clinical ischemic jeopardy with SPECT myocardial perfusion imaging [published online ahead of print, 2020 Jul 1]. J Nucl Cardiol. 2020;10.1007/s12350-020-02237-7. doi:10.1007/s12350-020-02237-7

Mahlof EN, Bisognano JD. Reducing cardiovascular risk caused by air pollution: individuals can make a difference. J Hum Hypertens (2020). doi:10.1038/s41371-020-00404-4

Lee EC, Goldenberg I, Vidula H. Response to "How to consider optimal therapeutic strategy for bridge to heart transplantation" [published online ahead of print, 2020 Jul 11]. Int J Cardiol. 2020;S0167-5273(20)33451-3. doi:10.1016/j.ijcard.2020.07.003

Aktas M, Bennett AL. Implantable Cardioverter Defibrillator Programming After First Occurrence of Ventricular Tachycardia in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Heart Rhythm O2. May 11, 2020.

Elbadawi A, Naqvi SY, Saad M, et al. In-Hospital Outcomes with Transfemoral Versus Transapical Access for Transcatheter Aortic Valve Replacement in Patients with Peripheral Arterial Disease. Cardiovasc Revasc Med. 2020;21(5):604-609. doi:10.1016/j.carrev.2019.09.009

Chen YL, Wright C, Pietropaoli AP, et al. Right ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis. 2020;49(1):34-41. doi:10.1007/s11239-019-01922-w

Vidula H, Lee E, McNitt S, et al. Cardiac Resynchronization Therapy and Risk of Recurrent Hospitalizations in Patients Without Left Bundle Branch Block: The Long-Term Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy. Circ Heart Fail. 2020;13(7):e006925. doi:10.1161/CIRCHEARTFAILURE.120.006925

Kutyifa V, Naqvi SY, Vidula H, et al. Clinical Significance of Early Hospital Readmission in Continuous-Flow Left Ventricular Assist Device Patients. ASAIO J. 2020;66(7):760-765. doi:10.1097/MAT.0000000000001065

Bisognano J, Bennett A. American Heart Association Hypertension Learning Guide Comprehensive Guide on Hypertension: Hypertensive Crisis. May 2020.

Bisognano J, Bennett A. American Heart Association Hypertension Learning Guide Comprehensive Guide on Hypertension: Coexisting Heart Disease. May 2020.

Kamran H, Hornacek D, Mix D, Wright C, Cameron SJ. A survey of commonly misunderstood vascular medicine physical exam findings among medical trainees. Vasc Med. 2020;25(4):351-353. doi:10.1177/1358863X20924100

Van Galen J, Pava L, Wright C, et al. Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism [published online ahead of print, 2020 Mar 6]. Platelets. 2020;1-3. doi:10.1080/09537104.2020.1732329

2019

Naqvi SY, Jawaid A, Vermilye K, et al. Left Ventricular Reverse Remodeling in Cardiac Resynchronization Therapy and Long-Term Outcomes. JACC Clin Electrophysiol. 2019;5(9):1001-1010. doi:10.1016/j.jacep.2019.07.012

Seif E, Sherazi S, Bravo-Jaimes K, Cheyne C, Alexis JD. Driving Pulseless: A Driving Survey of Patients With Left Ventricular Assist Devices and Their Providers [published correction appears in J Card Fail. 2019 Jul;25(7):582]. J Card Fail. 2019;25(3):220-221. doi:10.1016/j.cardfail.2019.02.003

Wright C, Elbadawi A, Chen YL, et al. The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department. J Thromb Thrombolysis. 2019;48(2):331-335. doi:10.1007/s11239-019-01875-0

Naqvi SY, Jain H, Prasad S, Stuver T. Management of Paravalvular Leak After Rapid Deployment Edwards Intuity Elite Valve. JACC Cardiovasc Interv. 2019;12(5):e39-e40. doi:10.1016/j.jcin.2018.12.023

Naqvi SY, Wittlin SD, Schwartz RG. Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges. J Nucl Cardiol. 2019;26(4):1103-1106. doi:10.1007/s12350-017-1177-4

Matsumoto C, Yoruk A, Wang L, Gaziano JM, Sesso HD. Fish and omega-3 fatty acid consumption and risk of hypertension. J Hypertens. 2019;37(6):1223-1229. doi:10.1097/HJH.0000000000002062

Bishop GJ, Gorski J, Lachant D, Cameron SJ. Chronic thromboembolic pulmonary hypertension is a clot you cannot swat. J Vasc Surg Cases Innov Tech. 2019;5(4):402-405. Published 2019 Sep 17. doi:10.1016/j.jvscit.2019.07.004

Ghisi GLM, Chaves GSDS, Bennett A, Lavie CJ, Grace SL. The Effects of Cardiac Rehabilitation on Mortality and Morbidity in Women: A META-ANALYSIS ATTEMPT. J Cardiopulm Rehabil Prev. 2019;39(1):39-42. doi:10.1097/HCR.0000000000000351

Elbadawi A, Elgendy IY, Naqvi SY, et al. Temporal Trends and Outcomes of Hospitalizations With Prinzmetal Angina: Perspectives From a National Database. Am J Med. 2019;132(9):1053-1061.e1. doi:10.1016/j.amjmed.2019.04.005

Elbadawi A, Naqvi SY, Elgendy IY, et al. Ethnic and Gender Disparities in the Uptake of Transcatheter Aortic Valve Replacement in the United States [published online ahead of print, 2019 Jun 25]. Cardiol Ther. 2019;8(2):151-155. doi:10.1007/s40119-019-0138-1

2018

Yoruk A, Boulos PK, Bisognano JD. The State of Hypertension in Sub-Saharan Africa: Review and Commentary. Am J Hypertens. 2018;31(4):387-388. doi:10.1093/ajh/hpx196

Jawaid A, Naqvi SY, Wiener R. Atrial myxoma presenting as acute ischaemic stroke and chronic right lower leg claudication. BMJ Case Rep. 2018;11(1):e227427. Published 2018 Dec 13. doi:10.1136/bcr-2018-227427

Naqvi SY, Jawaid A, Goldenberg I, Kutyifa V. Non-response to Cardiac Resynchronization Therapy. Curr Heart Fail Rep. 2018;15(5):315-321. doi:10.1007/s11897-018-0407-7

Naqvi SY, Salama IG, Yoruk A, Chen L. Ambulatory Intra Aortic Balloon Pump in Advanced Heart Failure. Card Fail Rev. 2018;4(1):43-45. doi:10.15420/cfr.2018:22:1

Seif E, Chen L, Goldman B. MD. Fulminant Myocarditis; a review of the current literature. US Cardiology Review (USC) issue 12.1, 2018.

Naqvi SY, Wittlin SD, Schwartz RG. Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges. J Nucl Cardiol. 2019;26(4):1103-1106. doi:10.1007/s12350-017-1177-4

Chong-Yik R, Bennett AL, Milani RV, Morin DP. Cost-Saving Opportunities with Appropriate Utilization of Cardiac Telemetry. Am J Cardiol. 2018;122(9):1570-1573. doi:10.1016/j.amjcard.2018.07.016

Kutyifa V, Naqvi SY, Brown M, et al. Comparison of Long-Term Survival Benefits With Cardiac Resynchronization Therapy in Patients With Mild Heart Failure With Versus Without Diabetes Mellitus (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT]). Am J Cardiol. 2018;121(12):1567-1574. doi:10.1016/j.amjcard.2018.02.040

Saha T, Naqvi SY, Goldberg S. Hybrid Revascularization: A Review. Cardiology. 2018;140(1):35-44. doi:10.1159/000488190

Elbadawi A, Wright C, Patel D, et al. The impact of a multi-specialty team for high risk pulmonary embolism on resident and fellow education. Vasc Med. 2018;23(4):372-376. doi:10.1177/1358863X18767753

Tafreshi S, Naqvi SY, Thomas S. Extra-adrenal pheochromocytoma presenting as inverse takotsubo-pattern cardiomyopathy treated with surgical resection. BMJ Case Rep. 2018;11(1):e226384. Published 2018 Dec 9. doi:10.1136/bcr-2018-226384