Student Researchers
Research Interest:
Investigating mechanisms that regulate transcription during terminal erythroid maturation
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Transcriptional and epigenetic regulation of hematopoietic cell lineage differentiation
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Improving LAIV Efficacy and Understanding Methods Underlying HIV Silencing in Astrocytes
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Elucidation of glutathione related dipeptide metabolism in cancer.
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Investigating the role of transcriptional pause-release factors in metabolically regulating cell lineage differentiation
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Understanding the effects of gestational vitamin B6 deficiency in offspring metabolic health
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Evolving AAVs to target specific cell types for the delivery of specific cell types of the CNS. Elucidating disease mechanisms and identifying therapeutic intervention for neurodegenerative disorders.
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Determining the role of epigenetic mark histone H4 lysine K20 tri-methylation (H4K20me3) at active enhancers upon TGF-beta-induced epithelial-to-mesenchymal transition (EMT) in breast cancer.
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Understanding the mechanism of pre-mRNA splicing regulation by the long non-coding RNA Neat1.
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Focusing on the molecular mechanisms underlying cancer invasion and metastasis, with a particular interest in developing and applying in vitro 3D models of muscle-invasive bladder cancer.
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Regulation of the transcriptional pause and its role in breast cancer.
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Investigating the role of glutathione homeostasis in intestinal disease progression.
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Developing novel thermodynamic parameters for RNA folding stability in simulated cellular environments to improve the accuracy of RNA secondary structure predictions.
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Hunger modulation of the feeding initiation circuit in Drosophila melanogaster.
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Understanding the mismatch of RNA secondary structure based on prediction models
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Studying the post-transcriptional modifications of tRNA and their molecular association with neurodevelopment
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Investigating the role of selective autophagy of organelles in development, differentiation, and disease.
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Focusing on glial cell replacement in the brain, using human glial chimeras to study how healthy and Huntington’s disease glia compete within the same host. By identifying the molecular drivers of competitive dominance, I hope to uncover new targets for glia-based therapies
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Restoring Redox/Fyn/c-Cbl (RFC) pathway function as a therapeutic target in non-small cell lung cancers and ovarian cancers, and using transcriptomic and proteomic data to predict additional cancer types of interest
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Understanding the role of Ki-67 in alveolar epithelium plasticity
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Investigating regulatory mechanisms directing phosphorylation dynamics in U2-dependent splicing.
Research Interest:
Evaluation of single-cell pathway scoring methods and characterization of monocytes in HIV-positive individuals with atherosclerosis.
Research Interest:
The role of SUMOylation of HSF1 in the coordination of the heat shock response
Research Interest:
The interplay between neuroimmune interactions and gestational insults on resulting neurodevelopmental sequelae and disease trajectories.