
Welcome to the Thakar Lab

Immune response to infections, vaccination and environmental exposures depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology, and dynamic modeling tools. We typically integrate different datasets including gene expression, metabolomics, single-cell RNA seq, proteomics, serum cytokine levels and known information about signaling and metabolic pathways. Recently, we are also working with adaptive immune receptor repertoire sequencing.

Juilee Thakar, Ph.D.
Principal Investigator
Publications
View All Publications- Development of a pediatric immune cell atlas and characterization of CD4+ T cells in food allergy.; Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology; Vol 37(4), pp. e70337. 2026 Apr.
- Monocytes Defined by Platelet Interactions and Oxidative Stress Signaling Underlie HIV-Associated Atherosclerosis.; Journal of the American Heart Association. 2026 Mar 13.
- Single cell analysis of neonatal naïve CD8α + T cells reveals novel subsets bridging the innate-adaptive spectrum.; bioRxiv : the preprint server for biology. 2026 Mar 09.
- Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy.; Science translational medicine; Vol 17(828), pp. eads1892. 2025 Dec 10.
- Value of Bioinformatics Models for Predicting Translational Control of Angiogenesis.; Circulation research; Vol 136(10), pp. 1147-1165. 2025 May 08.
- Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus.; Frontiers in immunology; Vol 15, pp. 1499551. 2025 Jan 10.
News
Affiliations
- Microbiology & Immunology
- Center for Biomedical Informatics
- NIH T32 Training Grant in Immunology
- Biomedical Genetics and Genomics Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Immunology, Microbiology, and Virology Ph.D. Program
- PhD Program in Pathology - Cell Biology of Disease
- Translational Biomedical Science Ph.D. Program
- Program for Advanced Immune Bioimaging
August 10, 2020
Thakar Lab publishes article on the Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature
August 3, 2019
Celebrating Juilee’s promotion to Associate level and acceptance of Rohith’s paper in PLoS Computational Biology
July 16, 2019
Juilee presented on use of metabolomics to infer signatures of HIV vaccine response at HVTN2019
March 16, 2019
Rohith Palli presenting at Cold Spring Harbor Systems Immunology meeting
Contact Us
Thakar Lab
KMRB 3-9834
601 Elmwood Ave
Rochester, NY 14642