Congratulations to Xiaoyi Liu as the recipient of Top Student/Trainee Abstract Award at the 2024 BCVS Scientific Sessions
Wednesday, July 24, 2024
Xiaoyi Liu, 5th year graduate student in the laboratory of Dr. Eric Small was the recipient of the Top Student/Trainee Abstract Award in The 2024 Early Career Poster Competition for her poster entitled, “P53 regulates the extent of fibroblast proliferation and fibrosis in left ventricle pressure overload”. Xiaoyi was presented this award at The American Heart Association Basic Cardiovascular Sciences (BCVS) 2024 Scientific Sessions, held in Chicago, IL on July 22-25, 2024.
Congratulations to Xiaoyi Liu as the Recipient of a Two-Year Predoctoral Fellowship from the American Heart Association
Monday, January 1, 2024
Xiaoyi Liu, 4th year graduate student in the laboratory of Dr. Eric Small was awarded a two-year American Heart Association Predoctoral Fellowship entitled, “Sprr2b/p53 dependent control of cardiac fibroblast proliferation and fibrosis”.
Project Summary
Heart disease is accompanied by the accumulation of cardiac fibroblasts that deposit extracellular matrix to generate a fibrotic scar. In this project, we will investigate how tumor suppressor proteins, including p53, control the magnitude and timing of cardiac fibroblast proliferation and cardiac fibrosis. We will also test a novel mechanism that regulates ubiquitin-mediated degradation of p53 in cardiac fibroblasts, via interactions with the Sprr2b protein. Ultimately, our findings will identify strategies to limit fibroblast expansion and the development of pathological cardiac fibrosis in heart disease.