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2022202120202019

The Lueck Lab is quoted in Chemical & Engineering News!

Sunday, September 19, 2021

More than 10% of all genetic diseases are caused by mutations that prevent cells from making fully formed proteins. An experimental therapy that uses suppressor transfer RNA (tRNA) could help overwrite these mutations and restore normal protein production.

Read More: The Lueck Lab is quoted in Chemical & Engineering News!

Hocking and Lueck Receive EDI Medicines Discovery Awards

Thursday, April 29, 2021

Harold

Dr. Denise Hocking

Harold

Dr. John Lueck

The Empire Discovery Institute (EDI), a non-profit New York drug discovery and development accelerator involving a partnership between the University of Rochester, the University at Buffalo, and Roswell Park Comprehensive Cancer Center, was created to transform academic discoveries into new medicines for commercialization. The EDI is supported by >$100 million in funds from both Empire State Development and Deerfield Management Company, a healthcare investment firm.

In the inaugural year of EDI's Medicines Discovery Award Program, Drs. Denise Hocking and John Lueck each received awards to support their innovative research programs in drug development. Dr. Hocking's award will support her work support her work in advancing the use of a novel chimeric fibronectin protein for wound healing. Dr. Lueck's award will support his research program's efforts to develop and test engineered tRNAs to treat a wide range of genetic diseases resulting from nonsense mutations.

Additional information of the EDI and the Medicines Discovery Award program can be found using the following link: https://www.urmc.rochester.edu/news/story/deerfield-and-empire-discovery-institute-partner-to-advance-life-sciences-r-d-in-rochester-buffalo

UR Center for RNA Biology RNA Presentation Contest Results

Tuesday, February 2, 2021

Thank you to those who participated in and/or viewed the UR Center for RNA Biology's RNA Presentations on Jan 6th, 13th, and 27th, sponsored by the RNA Society and Lexogen. The judging committee was impressed with the quality of the presentations given on all three dates, making final decisions difficult.

All nine of the graduate student, postdoc, and technician presenters, chosen based on their quality of their abstract, will be receiving a one-year membership to the RNA Society. Of these, four who were chosen based on the quality of their presentation will be awarded $375 each to be used toward the attendance of an RNA-centric meeting, in person or virtually.

The four to be awarded a one-year membership in the RNA Society and $375, in alphabetical order, are:

Kamel Awayda (presented Jan 6th )

Technician, Mitch O'Connell Lab

"Characterization of THUMP Domain-Containing Protein 1, and Putative Modulator of RNA Modification"

Chen Bao (presented Jan 13th)

Biochemistry Grad Student, Dmitri Ermolenko Lab

"mRNA Stem-Loops Can Induce Translational Pause through Two Pathways"

Xavier Rambout, PhD (presented Jan 27th)

Postdoc, Lynne Maquat Lab

"Transcriptional Coactivator PGC-1α Contains a Novel CBP80-Binding Motif that Orchestrates Efficient Target-Gene Expression"

Arica VanderWal (presented Jan 13th)

Biochemistry Grad Student, Mitch O'Connell Lab

"The Role of Csx28 in CRISPR-Cas13b Anti-Bacteriophage Defense"

The remaining to be awarded a one-year membership in the RNA Society, in alphabetical order, are:

Lily Cisco (presented Jan 6th )

Pharm-Phys Grad Student, John Lueck Lab

"Testing Therapeutic Intervention for Myotonic Dystrophy Type 1 in a Novel Mouse Model"

Xueyang He (presented Jan 6th )

Biophysics Grad Student, Paul Boutz Lab

"A Novel Method to Capture and Sequence Intron Lariats"

Shon Koren (presented Jan 6th )

Technician, Gail Johnson Lab

"Tau-Ribosome-tRNA Associations Underlie Common Features of Dys sincening Protein Synthesis in Dementia"

Sean Lindley (presented Jan 13th )

Biology Grad Student, Doug Anderson Lab

"StitchR: Ribozyme-Mediated RNA Trans-Splicing and Expression in Mammalian Cells"

Debanjana Maji (presented Jan 27th )

Biophysics Grad Student, Clara Kielkopf Lab

"Representative Cancer-Relevant U2AF2 Mutations Alter RNA Interactions and Splicing"