URMC / Labs / Maquat Lab / Publications Recent Publications Lucas BALavi EShiue LCho HKatzman SMiyoshi KSiomi MCCarmel LAres MMaquat LE (2018 Jan 16). Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay. Proceedings of the National Academy of Sciences of the United States of America. Rambout XDequiedt FMaquat LE (2017 Dec 18). Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing. Chemical reviews. Popp MWMaquat LE (2017 Nov 07). Nonsense-mediated mRNA Decay and Cancer. Current opinion in genetics & development. Elbarbary RAMiyoshi KHedaya OMyers JRMaquat LE (2017 Jul 15). UPF1 helicase promotes TSN-mediated miRNA decay. Genes & development. Elbarbary RAMaquat LE (2017 Jun 06). Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism. Nature structural & molecular biology. Elbarbary RAMiyoshi KMyers JRDu PAshton JMTian BMaquat LE (2017 May 26). Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science (New York, N.Y.). Gleghorn MLZhao JTurner DHMaquat LE (2016 Jun 10). Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation. Nucleic acids research. Popp MWMaquat LE (2016 Jun 2). Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine. Cell. Maquat LE (2016 Apr). Eukaryotic antisense ahead of its time. Nature reviews. Molecular cell biology. Elbarbary RAMaquat LE (2016 Mar 1). Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock. Genes & development. Elbarbary RALucas BAMaquat LE (2016 Feb 12). Retrotransposons as regulators of gene expression. Science (New York, N.Y.). Kurosaki TMaquat LE (2016 Feb 1). Nonsense-mediated mRNA decay in humans at a glance. Journal of cell science. Elbarbary RAMaquat LE (2015 Apr 1). CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention. Genes & development. Maquat LE (2015 Apr). The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences. RNA (New York, N.Y.). Popp MWMaquat LE (2015 Mar 20). RNA. A TRICK'n way to see the pioneer round of translation. Science (New York, N.Y.). Gong CMaquat LE (2015). Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods in molecular biology (Clifton, N.J.). Jackson KLDayton RDOrchard EAJu SRinge DPetsko GAMaquat LEKlein RL (2015 Jan). Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis. Gene therapy. Popp MWMaquat LE (2015). Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nature communications. Kurosaki TLi WHoque MPopp MWErmolenko DNTian BMaquat LE (2014 Sep 1). A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes & development. Gleghorn MLMaquat LE (2014 Jul). 'Black sheep' that don't leave the double-stranded RNA-binding domain fold. Trends in biochemical sciences. Popp MWMaquat LE (2014 Apr). Defective secretory-protein mRNAs take the RAPP. Trends in biochemical sciences. Elbarbary RAMaquat LE (2014). Dodging two bullets with one dsRNA-binding protein. Cell cycle (Georgetown, Tex.). Popp MWMaquat LE (2014 Jan). The dharma of nonsense-mediated mRNA decay in mammalian cells. Molecules and cells. Belfort MMarraffini LMacfarlan TBoeke JSlotkin KMalik HMaquat L (2014). Mobile DNA: an evolving field. Mobile DNA. Gong CTang YMaquat LE (2013 Oct). mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nature structural & molecular biology. Elbarbary RALi WTian BMaquat LE (2013 Jul 1). STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes & development. Park EMaquat LE (2013 Jul). Staufen-mediated mRNA decay. Wiley interdisciplinary reviews. RNA. Gleghorn MLGong CKielkopf CLMaquat LE (2013 Apr). Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nature structural & molecular biology. Wang JGong CMaquat LE (2013 Apr 1). Control of myogenesis by rodent SINE-containing lncRNAs. Genes & development. Trcek TSato HSinger RHMaquat LE (2013 Mar 1). Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes & development. Kurosaki TMaquat LE (2013 Feb 26). Rules that govern UPF1 binding to mRNA 3' UTRs. Proceedings of the National Academy of Sciences of the United States of America. Park EGleghorn MLMaquat LE (2013 Jan 8). Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proceedings of the National Academy of Sciences of the United States of America. Wang JLucas BAMaquat LE (2013). New gene expression pipelines gush lncRNAs. Genome biology. Popp MWMaquat LE (2013). Organizing principles of mammalian nonsense-mediated mRNA decay. Annual review of genetics. Gong CPopp MWMaquat LE (2012 Oct). Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods (San Diego, Calif.). Schoenberg DRMaquat LE (2012 Apr). Regulation of cytoplasmic mRNA decay. Nature reviews. Genetics. Hwang JMaquat LE (2011 Aug). Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Current opinion in genetics & development. Gong CMaquat LE (2011 Jun 15). "Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell cycle (Georgetown, Tex.). Ju STardiff DFHan HDivya KZhong QMaquat LEBosco DAHayward LJBrown RHLindquist SRinge DPetsko GA (2011 Apr). A yeast model of FUS/TLS-dependent cytotoxicity. PLoS biology. Gleghorn MLMaquat LE (2011 Mar 18). UPF1 learns to relax and unwind. Molecular cell. Gong CMaquat LE (2011 Feb 10). lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature. Hwang JSato HTang YMatsuda DMaquat LE (2010 Aug 13). UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Molecular cell. Maquat LETarn WYIsken O (2010 Aug 6). The pioneer round of translation: features and functions. Cell. Maquat LEHwang JSato HTang Y (2010). CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harbor symposia on quantitative biology. Maquat LEGong C (2009 Dec). Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochemical Society transactions. Sato HMaquat LE (2009 Nov 1). Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes & development. Schoenberg DRMaquat LE (2009 Sep). Re-capping the message. Trends in biochemical sciences. Isken OMaquat LE (2009). Telomeric RNAs as a novel player in telomeric integrity. F1000 biology reports. Gong CKim YKWoeller CFTang YMaquat LE (2009 Jan 01). SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes & development. Isken OMaquat LE (2008 Sep). The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nature reviews. Genetics.