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AIR Research Presented at National Meeting

November 4-8, 2017

The AIR Division was well represented at the American College of Rheumatology’s National Meeting in San Diego, CA November 4-8, 2017. This meeting highlights the most current research findings as they relate to Rheumatology. Ten faculty members and one fellow had a total of 23 presentations which included poster and oral abstract presentations, panel discussions, meet the professor sessions, study sessions and topic presentations.

John Looney, M.D. a Master of the American College of Rheumatology

November 4, 2017

At the 2017 National Meeting of the American College of Rheumatology, John Looney, M.D. was honored with one of the College’s highest honors. He was the recipient of its Master of the ACR designation. Recipients must “have made outstanding contributions to the field of rheumatology through scholarly achievement and/or service to their patients, students, and the rheumatology profession (and) devoted their long careers to furthering rheumatology research and improving clinical standards in the treatment of rheumatic diseases.”

Allen Anandarajah, M.D., MSc Awarded Grant From GRHF for his IQ-LUPUS Project

July 19, 2017

Dr. Allen Anandarajah was awarded a grant from the GRHF for his project to improve care for patients with SLE in the Rochester area who are at high risk for hospital admission. The goals of the project are to improve access to care and adherence to medication use, identify and modify behavioral and social impediments to on-going care and to provide an increased awareness of lupus in patients and the community.

Jennifer Anolik, M.D., Ph.D. to Share the Secret of Her Success

May 17, 2017

Dr. Jennifer Anolik will join 12 other Rochester women as they share the secrets of their success on Wednesday evening, May 17th. For more information, see the attached flyer.

John Looney, M.D. Awarded Grant to Study Bone Marrow IFNβ and Mesenchymal Stromal Cells

March 24, 2017

Dr. John Looney was awarded a grant from the Alliance for Lupus Research and Pfizer’s Center for Therapeutic Innovation Challenge Grant Program to examine the expression and function of IFNβ in SLE patients. Dr. Looney will characterize the regulation and unique functional properties of IFNβ in inducing MSC senescence and loss of immunosuppression function. In addition, the research will define the role of intracellular DNA/RNA sensing pathways in the induction of IFNβ in bone marrow and elucidate the effects of overexpression or silencing of key molecules in the signaling pathway including MAVS, STING, and cGAS on MSC IFNβ production.

Bethany Marston, M.D. Awarded Rheumatology Research Foundation Clinician Scholar Educator Award

March 24, 2017

Dr. Bethany Marston was awarded funding for her proposal "Rheum4Science: An Interactive Online Tutorial for Rheumatology Fellows." She will be converting materials on basic science and clinical research methodology written by experts in the field to consistent, user-friendly, and relevant eLearning modules using best practices for web-based curricula and evaluating the implementation of the Rheum4Science curriculum in practice using self-determination theory. In addition, Dr. Marston will Initiate and evaluate the effects of a Rheum4Science social media discussion group.

Maria Slack, M.D. Awarded American College of Allergy, Asthma & Immunology Young Investigator Award

March 24, 2017

Dr. Maria Slack was awarded funding for her proposal, “Gastrointestinal Dysregulation and Systemic Inflammation in Common Variable Immune Deficiency.” Dr. Slack will be investigating the IgA- and IgM-coated and uncoated microbiome and determining mucosal dysregulation and systemic immune activation in CVID.

Christopher Ritchlin, M.D., MPH attended NIAMS Roundtable Discussion on Gaps and Emerging Opportunities in Psoriatic Arthritis

March 20, 2017

Dr. Christopher Ritchlin recently participated in a NIAMS roundtable discussion focusing on opportunities and areas of need within psoriatic arthritis research.

Attendees of the NIAMS roundtable discussion on psoriatic  arthritis

Recently Published Journal Articles

Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers. Anna K. Bird, Martin Chang, Jennifer Barnard, Bruce I. Goldman, Nida Meednu, Javier Rangel-Moreno and Jennifer H. Anolik; J Immunol. 2017 July 15;199 (2) 458-466; DOI: https://doi.org/10.4049/jimmunol.1700354

Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1. Mease PJ; van der Heijde D; Ritchlin CT; Okada M; Cuchacovich RS; Shuler CL; Lin CY; Braun DK; Lee CH; Gladman DD. Annals of the rheumatic diseases. 2017; 76(1):79-87.

Psoriatic Arthritis. Ritchlin, CT, Colbert, RA, Gladman, DD. N Engl J. Med. 2017 Mar 9;376(10):957-970. Doi: 10.1056/NEJMra1505557

Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice. Ahmed M; Jiao H; Domingo-Gonzalez R; Das S; Griffiths KL; Rangel-Moreno J; Nagarajan UM; Khader SA Journal of leukocyte biology. 2017; Epub 2017 Mar 03.

HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population. Treerat P; Prince O; Cruz-Lagunas A; Muñoz-Torrico M; Salazar-Lezama MA; Selman M; Fallert-Junecko B; Reinhardt TA; Alcorn JF; Kaushal D; Zuñiga J; Rangel-Moreno J; Kolls JK; Khader SA Mucosal immunology. 2017; Epub 2017 Mar 01.

Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection. Treerat P; Prince O; Cruz-Lagunas A; Muñoz-Torrico M; Salazar-Lezama MA; Selman M; Fallert-Junecko B; Reinhardt TA; Alcorn JF; Kaushal D; Zuñiga J; Rangel-Moreno J; Kolls JK; Khader SA Mucosal immunology. 2017; Epub 2017 Mar 01.

Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential. Rahimi H; Bell R; Bouta EM; Wood RW; Xing L; Ritchlin CT; Schwarz EM Arthritis research & therapy. 2016; 18():194.

Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies. Thurmond RL; Greenspan A; Radziszewski W; Xu XL; Miao Y; Chen B; Ge T; Zhou B; Baker DG; Pavlova D; Ritchlin CT; Tanaka Y; Takeuchi T; Smolen. The Journal of rheumatology. 2016; 43(9):1637-42.

Targeting the interleukin-23/17 axis in axial spondyloarthritis. Paine A; Ritchlin CT. Current opinion in rheumatology. 2016; 28(4):359-67.

Psoriatic Arthritis and Burden of Disease: Patient Perspectives from the Population-Based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) Survey. Kavanaugh A; Helliwell P; Ritchlin CT. Rheumatology and therapy. 2016; 3(1):91-102.

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis. Coates LC; Kavanaugh A; Mease PJ; Soriano ER; Laura Acosta Felquer M; Armstrong AW; Bautista Molano W; Boehncke WH; Campbell W; Cauli A; Espinoza LR; FitzGerald O; Gladman DD; Gottlieb A; Helliwell PS; Elaine Husni M; Love TJ; Lubrano E; McHugh N; Nash P; Ogdie A; Orbai AM; Parkinson A; O'Sullivan D; Rosen CF; Schwartzman S; Siegel EL; Toloza S; Tuong W; Ritchlin CT. Arthritis & rheumatology. 2016; 68(5):1060-71.

New therapies for psoriasis and psoriatic arthritis. Ritchlin CT; Krueger JG Current opinion in rheumatology. 2016; 28(3):204-10

The Relationship between Focal and Generalized Bone Loss in Rheumatoid Arthritis. Anandarajah AP; El-Taha M; Peng C Current rheumatology reviews. 2016; Epub 2016 Sep 08.

Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice. Rangel-Moreno J; To JY; Owen T; Goldman BI; Smrcka AV; Anolik JH Arthritis & rheumatology. 2016; 68(9):2244-56.

Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation. Solleti SK; Srisuma S; Bhattacharya S; Rangel-Moreno J; Bijli KM; Randall TD; Rahman A; Mariani TJ FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016; 30(7):2615-26.

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Griffiths KL; Ahmed M; Das S; Gopal R; Horne W; Connell TD; Moynihan KD; Kolls JK; Irvine DJ; Artyomov MN; Rangel-Moreno J; Khader Nature communications. 2016; 7():13894.

DC-STAMP: A Key Regulator in Osteoimmunology. Chiu YH, Ritchlin, CT. J Cell Physiol. 2016 Nov;231(11):2402-7. doi: 10.1002/jcp.25389. Epub 2016 Jun 14.

Proceedings from The 8th Annual International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) Conference. Troum OM; Pimienta OL; Olech E; Østergaard M; Thiele R; Seraphine JL; Bruyn GA; Peterfy Seminars in arthritis and rheumatism. 2016; 45(6):e17-23.

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis
Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Anolik JH. Arthritis Rheumatol. 2016 Apr;68(4):805-16. doi: 10.1002/art.39489

Toward Quantitative Assessment of Rheumatoid Arthritis Using Volumetric Ultrasound. Cao K; Mills D; Thiele R; Patwardhan K IEEE transactions on bio-medical engineering. 2016; 63(2):449-58.