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UR Medicine Recognized for Excellence in Stroke Care

Monday, June 11, 2018

The American Heart Association/American Stroke Association (AHA/ASA) has once again honored the UR Medicine Strong Memorial Hospital for having achieved the highest standard of care for stroke. This award identifies hospitals that provide care that can speed the recovery and reduce death and disability for stroke patients.

Strong Memorial Hospital has received the 2018 AHA/ASA Get With The Guidelines program’s Stroke Gold Plus Quality Achievement Award.  The hospital was also recognized for the Target: Stroke Honor Role Elite Plus designation, which identifies hospitals that have consistently and successfully reduced door-to-needle time – the window of time between a stroke victim’s arrival at the hospital, the diagnosis of an acute ischemic stroke, and the administration of the clot-busting drug tPA.  If given intravenously in the first four and a half hours after the start of stroke symptoms, tPA has been shown to significantly reduce the effects of stroke and lessen the chance of permanent disability.

Read More: UR Medicine Recognized for Excellence in Stroke Care

Wilmot announces new Pilot Award recipients

Monday, April 30, 2018

Wilmot’s competitive seed-grant program aims to fund research projects that will generate preliminary data necessary to potentially apply for federal funding in the future. Thanks to financial support from two community organizations – Adding Candles for a Cure and the Edelman Gardner Cancer Research Foundation – four projects have received funding that started Jan. 1.

Mark Noble, Ph.D., Professor in the departments of Biomedical Genetics and Neuroscience, received a $50,000 grant for his project titled, “A biomarker for a novel glioblastoma (GBM) vulnerability.” The co-investigators for this project are Kevin Walter, M.D., Mahlon Johnson, M.D., Ph.D., Nimish Mohile, M.D., and Peggy Auinger, M.S.

Bradford Mahon, Ph.D., Assistant Professor in the Departments of Neurology and Neurosurgery, received a $50,000 grant for his project seeking to demonstrate feasibility and preliminary efficacy of advanced MRI mapping in improving outcome in patients with glioblastoma. Kevin Walter, M.D., is the co-investigator for this project.

Congratulations to all Wilmot pilot grant recipients.

Bogachan Sahin, M.D., Ph.D., Named Highland Hospital Chief of Neurology

Monday, April 23, 2018

Sahin

Dr. Sahin has been an Assistant Professor of Neurology at the University of Rochester’s School of Medicine and Dentistry since 2013. He earned his undergraduate degree in molecular biology at Princeton University and his M.D. and Ph.D. in Neuroscience at the University of Texas Southwestern Medical Center. Dr. Sahin completed his residency in neurology and fellowship in vascular neurology at Johns Hopkins University.

In 2015, he became the Director of the Vascular Neurology Fellowship Program at the University of Rochester Medical Center and has transformed the fellowship. In 2017, there were 76 Vascular Neurology Fellowship Programs across the United States and only 36 of them were filled. Under Dr. Sahin’s leadership, the University of Rochester’s program has filled for three consecutive years and counting.

“Dr. Sahin is an outstanding clinical neurologist and a passionate educator. We look forward to Dr. Sahin bringing the same positive leadership approach to Highland that he’s brought to the Vascular Neurology Fellowship Program as we continue to integrate and expand our acute care service,” said Robert G. Holloway Jr., M.D., M.P.H., Professor and Chair of the Department of Neurology at the University of Rochester Medical Center.

“Highland Hospital is a New York State Designated Primary Stroke Center and an integral part of our stroke care network in UR Medicine. As a board-certified Vascular Neurologist, Dr. Sahin will also serve as the Stroke Center Director, ensuring Highland Hospital maintains its vital role in providing excellent stroke care to our community,” said Curtis Benesch, M.D., M.P.H., Professor of Neurology and Neurosurgery and Medical Director, URMC Comprehensive Stroke Center.

Dr. Sahin follows Adam Kelly, M.D., who served as Highland Hospital’s Chief of Neurology for almost six years.

Read More: Bogachan Sahin, M.D., Ph.D., Named Highland Hospital Chief of Neurology

National Initiative Focuses on New Treatments for Lewy Body Dementia

Wednesday, April 18, 2018

The University of Rochester Medical Center (URMC) has been selected to participate in a national network created to develop new ways to diagnose and treat Lewy Body Dementia (LBD). The new initiative, which is being organized by the Lewy Body Dementia Association, will seek to raise awareness and advance research for this complex disorder.

“Lewy Body Dementia is a challenging, multifaceted disease and research to find new diagnostic tools and treatments is still in its infancy,” said URMC neurologist Irene Richard, M.D., who will serve as director of the URMC Lewy Body Dementia Association Research Center of Excellence. “This new network of will create an infrastructure of clinician researchers who understand the disease, are able to identify patients to participate in research, and have experience participating in multi-site clinical trials.”

LBD is a progressive brain disorder marked by abnormal protein deposits – called Lewy Bodies – in areas of the brain important for behavior, cognition, and motor control. This complex disease gives rise to a range of symptoms, including cognitive impairment, sleep disturbances, hallucinations, difficulty with blood pressure regulation, and problems with movement and balance. Individuals with the disease will often experience marked fluctuations in their levels of alertness and clarity of thought.

Read More: National Initiative Focuses on New Treatments for Lewy Body Dementia

Robert Holloway & Benjamin George Study Regional Stroke Care

Monday, April 16, 2018

New research shows that stroke patients are increasingly being transferred out of smaller community and rural hospitals and sent to larger medical centers for their care and rehabilitation. While this is a positive sign for patients who need more advanced treatments, the trend has drawbacks in terms of cost and points to the need to improve the coordination of care between hospitals.

“The underlying goal of stroke care is to get the right person to the right hospital at the right time,” said University of Rochester Medical Center (URMC) neurologist Benjamin George, M.D., M.P.H., a co-author of the study which appears this month in the journal Neurology. “The findings of this study show that in recent years community-based hospitals are erring on the side of caution and transferring more patients from their emergency departments to larger hospitals. Given the high cost and burden associated with these transfers, striking a balance between cost and need is essential.”

Read More: Robert Holloway & Benjamin George Study Regional Stroke Care

Telehealth, Exercise the Focus of World Parkinson’s Disease Day

Tuesday, April 10, 2018

The University of Rochester Medical Center (URMC) is helping lead two advocacy efforts to increase awareness of the value of telehealth for individuals with Parkinson’s. These activities coincide with World Parkinson’s Disease Day on April 11.

“The prevalence of Parkinson’s disease is increasing and the number of people with the disease is expected to more than double in the next 20 years,” said neurologist Ray Dorsey, M.D., director of the URMC Center for Health + Technology (CHeT). “Telemedicine, along with other technologies, will be key to meeting this growing demand and will serve to expand access to quality care, help reduce the burden of caregivers, and potentially lower costs.”

CHeT is working with the Parkinson’s Foundation to advocate for telehealth by encouraging all of the Foundation’s 18 Centers of Excellence to provide at least one telemedicine visit on April 11. Dorsey has undertaken several studies over the last decade to demonstrate the feasibility and effectiveness of connecting Parkinson’s patients with specialists using telemedicine. Results of a recent study funded by the Patient-Centered Outcomes Research Institute demonstrated that telemedicine can successfully deliver quality care.

In addition, CHeT has partnered with Burn Along – an online video fitness and wellness platform that offers hundreds of classes at all fitness levels – in inviting individuals with Parkinson’s disease, caregivers, family members, and advocates to participate in free classes to raise awareness of the importance of exercising for Parkinson disease. Studies have shown that exercise can help keep the symptoms of Parkinson’s at bay and may even slow the progression of the disease.

Burn Along has joined with Dance for PD – a Brooklyn-based company that has created dance classes for people with Parkinson’s – to produce videos for distribution on their website. Individuals who sign up for the free classes with Burn Along on April 11 will have access to all of the site’s video content for the entire month of April.

For more information or to sign up for free fitness classes for the month of April, visit: http://fit.burnalong.com/world-parkinson-day/

Read More: Telehealth, Exercise the Focus of World Parkinson’s Disease Day

Mobile Apps Could Hold Key to Parkinson’s Research, Care

Monday, March 26, 2018

By Mark Michaud

A new study out today in the journal JAMA Neurology shows that smartphone software and technology can accurately track the severity of the symptoms of Parkinson’s disease. The findings could provide researchers and clinicians with a new tool to both develop new drugs and better treat this challenging disease.

“This study demonstrates that we can create both an objective measure of the progression of Parkinson’s and one that provides a richer picture of the daily lived experience of the disease,” said University of Rochester Medical Center (URMC) neurologist Ray Dorsey, M.D., a co-author of the study.

One of the difficulties in managing Parkinson’s is that symptoms of the disease can fluctuate widely on a daily basis. This makes the process of tracking the progression of the disease and adjusting treatment a challenge for physicians who may only get a snapshot of a patient’s condition once every several months when they visit the clinic. This variation also limits the insight that researchers can gather on the effectiveness of experimental treatments.

The new study, which was led by Suchi Saria, Ph.D., an assistant professor of Computer Science at Johns Hopkins University, harnesses the capabilities of technology that already resides in most of our pockets all day, every day.

Researchers recruited 129 individuals who remotely completed a series of tasks on a smartphone application. The Android app called HopkinsPD, which was originally developed by Max Little, Ph.D., an associate professor of Mathematics at Aston University in the U.K., consists of a series of tasks which measure voice fluctuations, the speed of finger tapping, walking speed, and balance.

The Android app is a predecessor to the mPower iPhone app which was developed by Little, Dorsey, and Sage Bionetworks and has been download more than 15,000 times from Apple’s App Store since its introduction in 2015.

As a part of the study, the researchers also conducted in-person visits with 50 individuals with Parkinson’s disease and controls in the clinic at URMC. Participants were asked to complete the tasks on the app and were also seen by a neurologist and scored using a standard clinical evaluation tool for the disease. This aspect of the study was overseen by URMC’s Center for Health + Technology.

Read More: Mobile Apps Could Hold Key to Parkinson’s Research, Care

John Markman Elected to American Pain Society Board

Friday, March 16, 2018

markman

John Markman, M.D.

John Markman, M.D., professor of Neurosurgery and Neurology, was elected to the board of the American Pain Society in March of 2018.

The American Pain Society is the nation’s leading organization of scientists, physicians, and allied professionals focused on increasing knowledge of pain and transforming clinical practice and policy to reduce pain-related suffering. Markman founded and directs the University’s Neuromedicine Pain Management Center and Translational Pain Research Program. Together these programs were previously recognized as a Center of Excellence by the American Pain Society.

Congratulations Dr. Markman!

In Wine, There’s Health: Low Levels of Alcohol Good for the Brain

Friday, February 2, 2018

By Mark Michaud

While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study, which appears in the journal Scientific Reports, shows that low levels of alcohol consumption tamp down inflammation and helps the brain clear away toxins, including those associated with Alzheimer’s disease.

“Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system,” said Maiken Nedergaard, M.D., D.M.Sc., co-director of the Center for Translational Neuromedicine at the University of Rochester Medical Center (URMC) and lead author of the study. “However, in this study we have shown for the first time that low doses of alcohol are potentially beneficial to brain health, namely it improves the brain’s ability to remove waste.”

The finding adds to a growing body of research that point to the health benefits of low doses of alcohol. While excessive consumption of alcohol is a well-documented health hazard, many studies have linked lower levels of drinking with a reduced risk of cardiovascular diseases as well as a number of cancers.

Read More: In Wine, There’s Health: Low Levels of Alcohol Good for the Brain

Lungs Mays Hold Key to Thwarting Brain Damage after a Stroke

Wednesday, January 31, 2018

By Mark Michaud

The harm caused by a stroke can be exacerbated when immune cells rush to the brain an inadvertently make the situation worse. Researchers at the University of Rochester Medical Center (URMC) are studying new ways to head off this second wave of brain damage by using the lungs to moderate the immune system’s response.

“It has become increasingly clear that lungs serve as an important regulator of the body’s immune system and could serve as a target for therapies that can mitigate the secondary damage that occurs in stroke,” said URMC neurologist Marc Halterman, M.D., Ph.D. “We are exploring a number of drugs that could help suppress the immune response during these non-infection events and provide protection to the brain and other organs.”

Halterman’s lab, which is part of the Center for NeuroTherapeutics Discovery, has been investigating domino effect that occurs after cardiac arrest. When blood circulation is interrupted, the integrity of our intestines becomes compromised, releasing bacteria that reside in the gut into the blood stream. This prompts a massive immune response which can cause systemic inflammation, making a bad situation worse.

While looking at mouse models of stroke, his lab observed that a similar phenomenon occurs. During a stroke blood vessels in the brain leak and the proteins that comprise the wreckage of damaged neurons and glia cells in the brain make their way into blood stream. The immune system, which is not used to seeing these proteins in circulation, responds to these damage-associated molecular patterns and ramps up to respond. Mobilized immune cells make their way into the brain and, finding no infection, nevertheless trigger inflammation and attack healthy tissue, compounding the damage.

The culprit in this system-wide immune response is neutrophils, a white cell in the blood system that serves as the shock troops of the body’s immune system. Because our entire blood supply constantly circulates through the lungs, the organ serves as an important way station for neutrophils. It is here that the cells are often primed and instructed to go search for new infections. The activated neutrophils can also cause inflammation in the lungs, which Halterman suspects may be mistakenly identified as post-stroke pneumonia. The damage caused by activated neutrophils can also spread to other organs including the kidneys, and liver.

Read More: Lungs Mays Hold Key to Thwarting Brain Damage after a Stroke