Palis Lab The laboratory of Jim Palis and long-time colleagues Paul Kingsley and Kathleen McGrath consists of an interactive group of senior scientists, graduate students, technicians, and summer undergraduate students who participate in weekly lab meetings and lab journal clubs. We are located in the Center for Pediatric Biomedical Research on the first floor of the MRB-X building. Our research efforts are focused on better understanding the cellular and molecular events underlying the ontogeny of the hematopoietic system in the mammalian embryo. Our studies have focused on the emergence and differentiation of hematopoietic progenitors using the mouse embryo and embryonic stem cells as primary model systems. We are also investigating the response of the bone marrow to the toxic effects of ionizing radiation. Gaining insights into the ontogeny of mammalian hematopoiesis and its response to xenotoxic damage will ultimately lead to a better understanding of genetic disorders, bone marrow failure syndromes and leukemias, with a therapeutic goal of improving bone marrow transplantation for the curative treatment of numerous congenital anemias, genetic diseases, and several forms of childhood and adult cancers.