Investigators Francis Gigliotti, M.D., Chief Research Interests: Pathogenesis of disease caused by Pneumocystis carinii Infections in the immunocompromised host Pediatric AIDS clinical trials Publications: Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation: Role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol 2006;290(6):L1087-96. Wells J, Haidaris CG, Wright TW, Gigliotti F. Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia. Infect Immun 2006;74(1):390-3. Bhagwat SP, Gigliotti F, Xu H, Wright TW. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am J Physiol Lung Cell Mol Physiol 2006;291:L1256-66. Gigliotti F, Crow EL, Bhagwat SP, Wright TW. Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun 2006;74:6310-16. Samir Bhagwat, Ph.D. Research Interests: Lung injury during Pneumocystis carinii pneumonia Mary T. Caserta, M.D. Research Interests: Pathogenesis of HHV6 and HHV7 infection Transplacental transmission of HHV6 Immune response to HHV6 Publications: Caserta MT, Mock DJ, Dewhurst S. Human Herpesvirus 6. Clin Infect Dis 2001;33:829-833. Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S. Congenital infections with human herpesviruses 6 and 7. J Pediatr 2004;145:472-7. Caserta MT, McDermott MP, Dewhurst S, Schnabel K, Carnahan J, Gilbert L, Lathan G, Lofthus GK, Hall CB. Human Herpesvirus 6 (HHV6) DNA persistence and reactivation in normal children. J Pediatr 2004;145:478-84. Cynthia Christy, M.D. Research Interests: Influenza vaccine and children with asthma Medical student education Publications: Christy C, Aligne CA, Auinger P, Pulcino T, Weitzman M. Lack of effect of influenza vaccine for prevention of asthma exacerbations. Arch Dis Child 2004;89:734-35. Garfunkel LC, Kaczorowski J, Christy C (editors). The Pediatric Clinical Advisor. Mosby-Year Book, Inc., St. Louis, MO (2001). Damian J. Krysan, M.D., Ph.D. Research Interests: Yeast Aspartyl Proteases in Cell Wall Integrity: Investigating the role of a family of aspartyl proteases in yeast cell wall biosynthesis using a variety of biochemical, genetic and cell biological approaches Development of High Throughput Assay for Cell Wall-Targeted Antifungal Drugs: Developing assays to identify small molecules that disrupt cell wall biosynthesis by detecting cell lysis and activation of cell wall integrity stress response pathways Publications: Krysan DJ, Gilsdorf JR. Clinical research abstracts for pediatricians: Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children. J Pediatr 2004;144:406. Krysan DJ. Best Clinical Evidence Section: Effectiveness over time of varicella vaccination. J Pediatr 2002;145:416. Brenda Tesini, M.D. Geoffrey Weinberg, M.D. Research Interests: Pediatric AIDS clinical trials Vaccine-preventable disease epidemiology and laboratory diagnostics Publications: Weinberg GA, Erdman DD, Edwards KM, Hall CB, Walker FJ, Griffin MR, Schwartz B, and the New Vaccine Surveillance Network Study Group. Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis 2004;189:706-10. Griffin MR, Walker FJ, Iwane MK, Weinberg GA, Staat MA, Erdman DD, and the NVSN Study Group. Epidemiology of respiratory infections in young children: Insights from the New Vaccine Surveillance Network (NVSN). Pediatr Infect Dis J 2004;23:S188-S92. Weinberg GA, Burchett SL. Pediatric human immunodeficiency virus (HIV) infection. In: Mandell GL, Bennett JE, Dolin R (eds). Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases, 6th Edition. Philadelphia: Elsevier, 2005, pp. 1638-54. Melanie Wellington, M.D. Research Interets: Host defense against infection with Candida Fungal infections in children Infections in the immunocompromised host Publications: Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun 2003;71(12):7228-31. Bliss JM, Wellington M, Gigliotti F. Antifungal therapy for neonatal candidiasis. Sem Perinatol 2003;27(5):365-84. Terry W. Wright, Ph.D. Research Interests: Pneumocystis carinii biology Pathogenesis of lung injury during Pneumocystis carinii pneumonia Publications: Wells J, Haidaris CG, Wright TW, Gigliotti F. Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen. Infect Immun 2006;74(4):2446-8. Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation: Role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol 2006;290(6):L1087-96. Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O’Reilly MA. P21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol 2006;168(6):1838-47. Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco M, Finkelstein JN, O’Reilly MA. Type II epithelial cells are a critical target for hyperoxia mediated impairment of postnatal lung development. Am Physiol Lung Cell Mol Physiol 2006; in press; [Epub ahead of print].