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PTH 504 - Current Topics in Experimental Pathology

This course uses the seminar format to introduce students to diverse experimental and intellectual approaches to studying disease processes.  There are two required components: attendance at seminars given by other investigators and presentation of a student’s own work in the form of a seminar.  

The Pathology and Laboratory Medicine seminar series is usually held on Mondays at noon with scientists from both outside and within the University presenting their current research. Current seminar schedule.   

The Student Seminar Series is usually held on Fridays at noon with trainees from the Cell Biology of Disease program as speakers.  Each student gains experience in oral presentations by presenting his/her research work to the faculty and fellow students on a yearly basis.

Fall and spring semesters.  Credit: One hour.  Course Director: Richard Libby.

PTH 507 - Cancer Biology

The goal of this course is to provide a solid background and current understanding of cancer biology and cancer-related research.  The lectures will cover key topics in cancer biology, including intrinsic regulatory mechanisms of cancer cell proliferation, the impact of microenvironment on tumor growth and metastasis, and the diagnosis and prognosis of cancer. Leading cancer biologists will deliver lectures on each topic and lead in-depth discussions centered on groundbreaking findings.  As an advanced-level course, this course will emphasize original experiments, critical thinking and reading of the primary literature rather than abstract facts and memorization.  Active participation and in-class discussions among students are expected.  

This course is offered as a mandatory requirement for post-doctoral fellows on the Cancer Center Training Grant and as an upper level elective for graduate students campus-wide.

Fall semester. Two 1-1/2 hour sessions per week. Credit: three hours. Course Director: Helene McMurray.  No audits allowed.

PTH 509/510 - Cell Biology of Human Disease I and II

This two-semester course is the signature course of the graduate program in Pathology.  Its objective is to provide students with an introduction to human disease processes with an emphasis on molecular, cellular and genetic approaches to investigate human diseases and disease-related animal models.  Significant emphasis will be placed on the current understanding of disease processes, limitations, and strategies for innovative experimentation that should lead to breakthrough discoveries and cures.  They will complete the course with an understanding of the basic principles of human disease processes at the whole animal, organ, cellular, and molecular levels.

Lectures are complemented by interactive labs and journal clubs to expand on what is taught in class.  In journal club sessions, students will learn to critically read and evaluate scientific papers and will gain experience in presenting to their peers.  Discussions will address various diseases including but not limited to cardiovascular, neurological and musculoskeletal abnormalities, autoimmunity, endocrine defects and cancer.

Two 1 1/2-hour lectures and one 1 1/2-hour lab or journal club per week. Credit: four hours. Prerequisite: permission of the course director.  Course Directors: Catherine Ovitt (fall) and Cheryl Ackert-Bicknell (spring). No audits allowed.

PTH 595 - Ph.D. Research

Ph.D. research, done under the direction of a faculty member affiliated with the Cell Biology of Disease Ph.D. program at the University of Rochester.

Credit: to be arranged.