The Pathology PhD program has research groups investigating a wide variety of topics in cancer biology. The James P. Wilmot Cancer Institute (WCI) is leading efforts in cancer biology at the University and includes faculty from many different clinical and basic science departments. Areas under current investigation include radiation biology, solid tumor biology, blood cancers, cancer biomarkers, cancer susceptibility factors, cancer genomics, cancer immunology, and cancer therapeutics.
- Brian Altman, PhD (Biomedical Genetics, WCI)
- Jeevisha Bajaj, PhD (Biomedical Genetics, WCI)
- Laura Calvi MD (Medicine, WCI)
- Darren R. Carpizo, MD, PhD (Surgery, WCI)
- Chawnshang Chang PhD (Pathology and Laboratory Medicine, WCI)
- Roman Eliseev, MD, PhD (Orthopaedics, WCI)
- Benjamin Frisch, PhD (Pathology and Laboratory Medicine, WCI)
- Scott Gerber, PhD (Surgery, WCI)
- Stephen Hammes MD, PhD (Medicine, WCI)
- Isaac Harris, PhD (Biomedical Genetics, WCI)
- Minsoo Kim PhD (Microbiology and Immunology, WCI)
- Yi-Fen Lee PhD (Urology, WCI)
- Archibald Perkins MD, PhD (Pathology and Laboratory Medicine, WCI)
- Paula Vertino, PhD (Biomedical Genetics, WCI)
- Zhenqiang Yao, PhD (Pathology and Laboratory Medicine, WCI)
- Shuyuan Yeh PhD (Urology, WCI)
Cell Biology and Genetics of Human Disease
The Pathology PhD program includes research groups studying a vast array of disorders affecting the cardiovascular system. Many are members of the Cardiovascular Research Institute (CVRI). These groups use state of the art cell biological and clinical tools to investigate heart and blood vessel function and disease states, with particular focus on determining the molecular pathways controlling cardiac and vessel disease, developing new diagnostic tools for early detection of cardiovascular disease, and using regenerative biology to speed recovery.
- Bradford Berk, MD (Medicine – Cardiology, CVRI)
- Paul Brookes, PhD (Anesthesiology)
- Alison Elder, PhD (Environmental Medicine)
- Angela Glading, PhD (Pharmacology & Physiology)
- Craig Morrell, DVM, PhD (CVRI)
- Jinjiang Pang, B.Med., Ph.D (CVRI)
- Eric Small, PhD (CVRI)
- Chen Yan, PhD (CVRI)
- Peng Yao, PhD (CVRI)
Lung Biology and Disease
The Pathology PhD program includes research groups interested in the underlying cell biology and physiology of lung development and disease. Many are members of the Lung Biology and Disease Program. There are active research programs probing developmental lung disorders, complications following surgery, the effects of environmental exposure on lung function, and age related lung disease. Research topics include lung cancer, neonatal lung disease that results from premature birth, chronic obstructive pulmonary disease (COPD), infection, environmental exposure of airborne toxins, asthma, and lung scarring.
Metabolic Disorders, Reproduction and Physiology
Many of our Pathology PhD program researchers are focused on disorders of metabolic processes and basic cellular physiology. Work in these areas include extensive efforts studying diabetes, diabetic retinopathy, cellular stress, mitochondrial biology and disorders, fertility and obesity.
- Brian Altman, PhD (Biomedical Genetics)
- Dirk Bohmann, PhD (Biomedical Genetics)
- Paul Brookes, PhD (Anesthesiology)
- Chawnshang Chang PhD (Pathology and Laboratory Medicine)
- Kavaljit Chhabra, M. Pharm., PhD (Medicine)
- Roman A. Eliseev, M.D., Ph.D. (Medicine)
- Lauren Hablitz, Ph.D. (Neurology - Neuromedicine)
- Stephen Hammes, MD, PhD (Medicine)
- Hae-Ryung Park, PhD (Environmental Medicine)
Neurologic and Sensory Systems Biology
The University of Rochester has active research programs investigating the biology underlying neurologic and sensory system function. Using a variety of advanced cell biological techniques, these groups study low vision and blindness, hearing and balance disorders, and oral disease. There is a wide spectrum of research in these areas, from developmental disorders affecting children to age-related sensory loss.
The University of Rochester has researchers investigating many different neurological diseases. These groups, which span over 10 departments and multiple centers, study both neurological disease (e.g. Alzheimer’s disease, stroke, spinal cord injury, psychiatric disorders) and fundamental biology of the brain that contributes to disease onset and progression (e.g. glial biology, neuroinflammation, glymphatic system). Furthermore, neurodegenerative diseases are studied using a variety of models systems, and in patients.
Hematology and Immunology
The Pathology PhD program has research groups investigating a variety of topics related to inflammation, blood borne disease, and immune system dysfunction. These groups work in numerous departments and centers throughout the University of Rochester. Current areas being actively studied include autoimmune disorders, leukemia, immune responses to bacterial and viral infections, tumor immunology and susceptibility to allergy.
- Kirsti Jarvinen-Seppo, MD, PhD (Pediatrics)
- Minsoo Kim, PhD (Microbiology and Immunology)
- Benjamin Korman, MD (Medicine)
- Craig Morrell, DVM, PhD (Medicine)
- James Palis MD (Pediatrics)
- Homaira Rahimi, MD (Pediatrics)
- Regina Rowe, MD, PhD (Pediatrics)
- Laurie Steiner, MD (Pediatrics)
- Juilee Thakar, PhD (Microbiology & Immunology)
- Terry Wright, PhD (Microbiology and Immunology, Pediatrics)
Orthopaedics and Musculoskeletal Research
The Pathology PhD program faculty study various aspects of the musculoskeletal system. Many of these faculty are members of the URMC Center for Musculoskeletal Research, one the nation’s top NIH funded centers for orthopaedic research. Major research areas include bone biology and disease, cartilage biology and arthritis, musculoskeletal stem cell biology, musculoskeletal repair and maintenance, musculoskeletal development, and bone cancer biology.
- Jennifer Jonason, PhD (Orthopaedics)
- Alayna Loiselle, PhD (Orthopaedics)
- Ed Puzas, PhD (Orthopaedics)
- Edward Schwarz, PhD (Orthopaedics)
- Chia-Lung Wu, PhD (Orthopaedics, CMSR)
- Lianping Xing, BMed, PhD (Pathology and Laboratory Medicine)
- Zhenqiang Yao, B. Med, PhD (Pathology and Laboratory Medicine)
- Xinping Zhang, BMed, PhD (Orthopaedics)