Microsphere Delivery of Immunotherapy Agents to Tumors
Booyeon Han (Linehan and Gerber Labs) publishes her work on the delivery of microsphere-encapsulated immunomodulatory agents to the tumor microenvironment. Using a model of pancreatic ductal adenocarcinoma, Booyeon found that within hours of intratumoral delivery, microspheres containing IL-12 were found in the tumor, lymphatics, and draining lymph node. The drainage of IL-12 microspheres from the tumor to the lymph node boosted Th1 cells and induced an antitumor cytokine profile that was essential for treatment efficacy. This efficacy was abrogated with draining lymph node ablation as noted by continued tumor growth and decreased survival. These studies demonstrate the potential for microsphere delivery of factors that locally modulate both tumor and lymph node microenvironments to enhance antitumor activity.
URMC Research Awards
Maureen Banach Melville A. Hare Award for excellence in Research
Maxime Jean Melville A. Hare Award for excellence in Research
Zanah Francis Melville A. Hare Award for excellence in Teaching
Janelle Veazey Outstanding Student Mentor Award
Best Department Seminar - 2019
- Jonathan Pinney - 3rd year
Science Policy Memo Writing Contest (3 prizes all to IMV students) – 2019
- Janelle Veazey
- Nicholas Battaglia
Recent Student Papers:
- Alissa Trzeciak
Title: Long-Term Microgliosis Driven by Acute Systemic Inflammation
Authors: Trzeciak, A, Yelena, VL, Kim, TH, Kim, MR, Mai, N, Marc, WH and Kim, M
Journal: Journal of Immunology
Links: Cover Images, Top Reads
- Daphne Pariser
Title: The Little Platelet That Could: PF4’s Regulation of Immune Responses.
Authors: Pariser, DN, Hilt, ZT, Bennett, JA, Morrell, CN
Journal: ASHI Quarterly
- Jonathan Pinney
Journal: Journal of Cell Science paper
*Waiting on response about paper acceptance
- Vascular Discovery: From Genes to Medicine Travel Award for Young Investigators, Council of Atheriosclerosis, Thrombosis, and Vascular Biology, 2019
- National Heart, Lung, And Blood Institute of the National Institutes of Health F31, NIH, 2019-2021, 1F31HL147458-01
- National Heart, Lung, And Blood Institute of the National Institutes of Health F31, NIH, 2018-2020, 1F31HL140795
- National Institutes of Health F31CA254132, “Double Duty: Elucidating the Effects of Estrogen on Tumor Cells and their Microenvironment in Lymphangioleiomyomatosis”
Project Summary: Lymphangioleiomyomatosis (LAM), a destructive cystic lung disease caused by TSC2-null, estrogen-sensitive, metastatic tumors, has a notable female sexual dimorphism and limited therapeutic options. Succinctly, the project is designed to delineate the mechanisms of estrogen actions in a murine model for Lymphangioleiomyomatosis (LAM) tumor growth, focusing on direct estrogen stimulation of TSC2-null LAM cells as well as estrogen involvement in the actions of granulocytic cells that infiltrate and promote LAM tumors.
Travel to Conferences
- Abstracts by Nick Battaglia, Cassandra Houser, and Janelle Veazey were selected for short talks at the 2019 Upstate New York Immunology Conference.
- A little about the conference by Janelle Veazey: “The Upstate Immunology conference is one of my favorites. It's a great chance to have lunch/dinner with the invited speakers including the keynotes! This year they also ran a mock study section, which was helpful to see what parts of your grant reviewers look at and discuss as well as better understand how [grant] scoring works.”