Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: The role of B cells in the pathophysiology of human systemic lupus and
rheumatoid arthritis and the study of new immuno-modulatory treatments
Role of Type 3 Interferon in the Pathophysiology of Systemic Lupus
Research Interest: Cutaneous allergic inflammation, Atopic Dermatitis (eczema)
Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow
Research Interest: Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.
Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
Research Interest: Type Three Secretion System mediated pathogenesis of V. cholerae
Translational women’s health research; To identify previously unknown mechanisms of disease for disabling vulvar conditions, namely vulvodynia and lichens
Research Interest: Role of inflammatory mediators in bone marrow microenvironmental dysfunction during hematologic malignancies
Research Interest: Molecular mechanisms and potential pharmacological and gene therapeutic interventions for neurologic disease associated with HIV-1 infection of the central nervous system.
Defining molecular mechanisms for respiratory-virus induced epithelial barrier dysfunction; exploring the use of oscillometry in the diagnosis and management of airways disorders; and determining how race neutral PFT interpretation strategies impact the utility of spirometry
Research Interest: The Gerber lab studies tumor immunology with a focus on harnessing the immune system to recognize and kill cancerous cells utilizing an immunotherapeutic approach to enhance the efficacy of chemo/radiotherapies to control or even cure both primary and metastatic malignancies.
Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.
Research Interest: Androgen Effects on Reproduction and Cancer
Food allergies disorders, caused by milk, eggs and peanuts.
Research Interest: Innate and adaptive immune responses and cancer immunotherapy
Research Interest: Cellular and molecular processes leading to scleroderma (fibrosis)
Research Interest: Influence of environmental factors on the development and function of the immune system
Translational cancer research and immunotherapy
Research Interest: Cell Mediated Immunity to Tumors
Research Interest: Glia-neuron interactions during synaptic plasticity in health and disease
Developing methods to estimate gene regulatory networks from gene perturbation experiments
Cell Motility, and Quantitative light microscopy
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Research Interest: Platelet functions in hemostasis/thrombosis and vascular inflammation. Platelet driven immune responses.
Research Interest: The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: The basic biology of glial cells in the CNS and the role of astrocytes in several neurological diseases, including stroke, spinal cord injury, epilepsy, tremor, and ALS. Research is aimed at defining new strategies for the treatment of neurological diseases that target astrocytic dysfunction.
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Human Skin Immunology
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology
Mechanisms of how allergic inflammation impacts innate immune cell antiviral responses.
Research Interest: Influenza specific immunity, vaccine design and regulation of T cell responses to pathogens.
Neonatal immunology; T cell function in preterm infants
Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants
Research Interest: Studying the mechanisms by which Human Immunodeficiency Virus (HIV) and its close relative Simian Immunodeficiency Virus (SIV) circumvent the barriers of the innate immunity in their respective hosts and cause Acquired Immunodeficiency Syndrome (AIDS)
Research Interest: Platelet - monocyte complex formation
To better understand the mechanisms that control cell identity and lineage commitment by studying the transcriptional regulation and function of cardiac tissue-restricted genes
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Research Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.
Research Interest: Innate immunity, Host-microbial interactions, Immunoparasitology, Mucosal immunology