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  • Munger Research - microscope photo

Virus-Host Interactions that Determine Infectious Outcomes

Kegg Pathway

Representation of the cellular metabolome.
(Modified from the KEGG Pathway Database)
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A major focus of our laboratory is  human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HCMV infection also poses a serious health risk to immunosuppressed individuals, increasing morbidity in the elderly and in patients receiving immunosuppressive chemotherapy, including cancer patients, transplant recipients, and AIDS patients.

The majority of the projects in our lab study the interfaces between viruses and the host cell that determine the outcome of infection. Specifically, we focus on how viruses usurp cellular metabolic controls and subvert cellular anti-viral signaling to support productive infection. The goal of our laboratory is to increase our mechanistic understanding of these processes to identify novel avenues for therapeutic intervention that could prevent virally-associated pathogenesis.      

Joshua C. Munger, Ph.D.

Joshua C. Munger, Ph.D.
Principal Investigator

Publications

    1. Asantewaa G
    2. Tuttle ET
    3. Ward NP
    4. Kang YP
    5. Kim Y
    6. Kavanagh ME
    7. Girnius N
    8. Chen Y
    9. Duncan R
    10. Rodriguez K
    11. Hecht F
    12. Zocchi M
    13. Smorodintsev-Schiller L
    14. Scales TQ
    15. Taylor K
    16. Alimohammadi F
    17. Sechrist ZR
    18. Agostini-Vulaj D
    19. Schafer XL
    20. Chang H
    21. Smith Z
    22. O'Connor TN
    23. Whelan S
    24. Selfors LM
    25. Crowdis J
    26. Gray GK
    27. Bronson RT
    28. Brenner D
    29. Rufini A
    30. Dirksen RT
    31. Hezel AF
    32. Huber AR
    33. Munger J
    34. Cravatt BF
    35. Vasiliou V
    36. Cole CL
    37. DeNicola GM
    38. Harris IS
    Glutathione supports lipid abundance in vivo.; bioRxiv : the preprint server for biology. 2023 Feb 11.
    1. Goodrum F
    2. Lowen A
    3. Lakdawala S
    4. Alwine J
    5. Casadevall A
    6. Imperiale M
    7. Atwood W
    8. Avgousti D
    9. Baines J
    10. Banfield B
    11. Banks L
    12. Bhaduri-McIntosh S
    13. Bhattacharya D
    14. Blanco-Melo D
    15. Bloom D
    16. Boon A
    17. Boulant S
    18. Brandt C
    19. Broadbent A
    20. Brooke C
    21. Cameron C
    22. Campos S
    23. Caposio P
    24. Chan G
    25. Cliffe A
    26. Coffin J
    27. Collins K
    28. Damania B
    29. Daugherty M
    30. Debbink K
    31. DeCaprio J
    32. Dermody T
    33. Dikeakos J
    34. DiMaio D
    35. Dinglasan R
    36. Duprex WP
    37. Dutch R
    38. Elde N
    39. Emerman M
    40. Enquist L
    41. Fane B
    42. Fernandez-Sesma A
    43. Flenniken M
    44. Frappier L
    45. Frieman M
    46. Frueh K
    47. Gack M
    48. Gaglia M
    49. Gallagher T
    50. Galloway D
    51. García-Sastre A
    52. Geballe A
    53. Glaunsinger B
    54. Goff S
    55. Greninger A
    56. Hancock M
    57. Harris E
    58. Heaton N
    59. Heise M
    60. Heldwein E
    61. Hogue B
    62. Horner S
    63. Hutchinson E
    64. Hyser J
    65. Jackson W
    66. Kalejta R
    67. Kamil J
    68. Karst S
    69. Kirchhoff F
    70. Knipe D
    71. Kowalik T
    72. Lagunoff M
    73. Laimins L
    74. Langlois R
    75. Lauring A
    76. Lee B
    77. Leib D
    78. Liu SL
    79. Longnecker R
    80. Lopez C
    81. Luftig M
    82. Lund J
    83. Manicassamy B
    84. McFadden G
    85. McIntosh M
    86. Mehle A
    87. Miller WA
    88. Mohr I
    89. Moody C
    90. Moorman N
    91. Moscona A
    92. Mounce B
    93. Munger J
    94. Münger K
    95. Murphy E
    96. Naghavi M
    97. Nelson J
    98. Neufeldt C
    99. Nikolich J
    100. O'Connor C
    101. Ono A
    102. Orenstein W
    103. Ornelles D
    104. Ou JH
    105. Parker J
    106. Parrish C
    107. Pekosz A
    108. Pellett P
    109. Pfeiffer J
    110. Plemper R
    111. Polyak S
    112. Purdy J
    113. Pyeon D
    114. Quinones-Mateu M
    115. Renne R
    116. Rice C
    117. Schoggins J
    118. Roller R
    119. Russell C
    120. Sandri-Goldin R
    121. Sapp M
    122. Schang L
    123. Schmid S
    124. Schultz-Cherry S
    125. Semler B
    126. Shenk T
    127. Silvestri G
    128. Simon V
    129. Smith G
    130. Smith J
    131. Spindler K
    132. Stanifer M
    133. Subbarao K
    134. Sundquist W
    135. Suthar M
    136. Sutton T
    137. Tai A
    138. Tarakanova V
    139. tenOever B
    140. Tibbetts S
    141. Tompkins S
    142. Toth Z
    143. van Doorslaer K
    144. Vignuzzi M
    145. Wallace N
    146. Walsh D
    147. Weekes M
    148. Weinberg J
    149. Weitzman M
    150. Weller S
    151. Whelan S
    152. White E
    153. Williams B
    154. Wobus C
    155. Wong S
    156. Yurochko A
    Virology under the Microscope-a Call for Rational Discourse.; mBio. 2023 Jan 26.
    1. Ciesla J
    2. Moreno I
    3. Munger J
    TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state.; PLoS pathogens; Vol 18(7), pp. e1010722. 2022 Jul 14.
    1. Moreno I
    2. Rodríguez-Sánchez I
    3. Schafer X
    4. Munger J
    Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(49), pp. e2205789119. 2022 Jan 02.
    1. Raymonda MH
    2. Ciesla JH
    3. Monaghan M
    4. Leach J
    5. Asantewaa G
    6. Smorodintsev-Schiller LA
    7. Lutz MM
    8. Schafer XL
    9. Takimoto T
    10. Dewhurst S
    11. Munger J
    12. Harris IS
    Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
    1. Monaghan M
    2. Munger J
    Contributions of the HCMV UL30-associated open reading frames to infection.; Journal of virology. 2021 Feb 10.

View All Publications

Contact Us

  Munger Lab
MC 3-7544
601 Elmwood Ave
Rochester, NY 14642

 (585) 273-4801

  (585) 271-2683