Lactate Dehydrogenase (CSF)
Does this test have other names?
Lactic acid dehydrogenase (CSF), LDH CSF
What is this test?
This test measures the amount of the enzyme lactate dehydrogenase (LDH) in your cerebrospinal
CSF is the clear liquid that surrounds the brain and spinal cord. Enzymes are catalysts,
or chemicals in your tissues and organs that cause the reactions necessary to provide
energy to your cells.
This test can help diagnose diseases and conditions that affect your central nervous
system, such as:
Jakob-Creutzfeldt disease, a rare, degenerative brain disorder that is fatal. Symptoms
include impaired memory and judgment, impaired vision, muscle jerks, and personality
changes. It primarily affects people in their 50s, 60s, and 70s.
Bacterial meningitis, an infection of the protective layers of tissue, or meninges,
that surround the brain and spinal cord. Symptoms of bacterial meningitis include
headache, fever, neck stiffness, nausea, vomiting, and confusion.
Neurosyphilis, an infection of the brain or spinal cord. Neurosyphilis is different
from syphilis, a sexually transmitted disease, because it affects the nervous system.
But people with untreated syphilis are susceptible to neurosyphilis. Neurosyphilis
may have no symptoms, or it may cause headaches, memory loss, and visual problems.
Tumors of the central nervous system
Why do I need this test?
You may have this test if your healthcare provider suspects that you have a disease
or condition that affects your central nervous system.
You may also have this test to see if cancer has spread to your brain and spinal cord.
What other tests might I have along with this test?
Your healthcare provider may also order a glucose test to measure the amount of sugar
in your CSF.
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
Results are given in units per liter (units/L). Normal findings for lactate dehydrogenase
in CSF are:
If your LDH level is higher, it means you may have an infection or inflammation in
your central nervous system.
Higher LDH levels may also mean you have a disease that affects your brain or spinal
cord, such as bacterial meningitis, neurosyphilis, or tumors that have spread to the
brain or spinal cord.
How is this test done?
This test requires obtaining a sample of your cerebrospinal fluid. Your healthcare
provider will take the sample through a lumbar puncture, or spinal tap, using a thin
needle. The needle will be pushed into your lower back, and fluid will be removed.
Does this test pose any risks?
A lumbar puncture, or LP, carries these possible risks:
What might affect my test results?
Other factors aren't likely to affect your results.
How do I get ready for this test?
Empty your bladder and bowels before testing. In addition, be sure your healthcare
provider knows about all medicines, herbs, vitamins, and supplements you are taking.
This includes medicines that don't need a prescription and any illicit drugs you may