Bile Duct Cancer: Chemotherapy
What is chemotherapy?
Chemotherapy (or chemo) uses strong medicines to kill cancer cells. The medicines
attack and kill cells that divide and grow quickly, like cancer cells. But some normal
cells also divide and grow quickly. Because of this, chemotherapy can also affect
these cells, which can lead to side effects.
When might chemotherapy be used to treat bile duct cancer?
Chemotherapy can help some people with bile duct cancer. It may be used for these
After surgery, often with radiation therapy, to kill any cancer cells left in the
body and help lower the risk that the cancer will come back
Before surgery to shrink tumors so they're easier to remove
To slow cancer growth and shrink tumors to relieve symptoms and help people live longer.
This may be done if you can't have surgery or if you have advanced cancer that has
How is chemotherapy given for bile duct cancer?
Chemo medicines are injected into a vein or given by mouth. They then go into the
bloodstream and reach all parts of the body. This is called systemic treatment.
Sometimes chemo is given right into the main artery that goes into the liver. This
treatment is called hepatic artery infusion. It focuses the chemo on the tumors in
the bile duct, and then the healthy liver gets rid of most of it. This limits the
amount of chemo that goes to the rest of the body. Chemo is not often given this way,
but it may help people who can't have surgery live longer.
Which chemotherapy medicines are used to treat bile duct cancer?
These are the medicines most often used to treat bile duct cancer. They might be given
alone, or two or more may be used at the same time:
Researchers are looking for new and better ways to treat bile duct cancer with chemotherapy.
These treatments are tested in clinical trials. Ask your healthcare provider if you
should think about being part of a clinical trial.
Targeted drug treatments that work directly on the changes that occur in cancer cells
may work if standard chemotherapy does not.
What are the side effects of chemotherapy?
Side effects are common with chemotherapy. But it's important to know that they can
often be controlled or even prevented. Most chemo side effects usually go away over
time after treatment ends. Side effects depend on the type and dose of chemo you’re
getting. They vary from person to person.
Some common side effects include:
Nausea and vomiting
Skin irritation or rash
Loss of appetite
Increased chance of infection
Increased chance of bleeding or bruising
Numbness, tingling, or pain in the hands or feet (neuropathy)
Working with your healthcare provider
It's important to know which medicines you're taking. Write down the names of your
medicines. Ask your healthcare team how they work, what they're for, and what side
effects you could have.
Talk with your healthcare providers about what side effects to watch for and when
to call them. Be sure you know how to get help any time, including after office hours
and on holidays and weekends.
It may be helpful to keep a diary of your side effects. Write down physical and emotional
changes. A written list will make it easier for you to remember your questions when
you go to your appointments. It will also make it easier for you to work with your
medical team to make a plan to manage your side effects.