What is a liver transplant?
A liver transplant is a surgical procedure performed to replace a diseased liver with
a healthy liver from another person. The liver may come from a deceased organ donor
or from a living donor. Family members or individuals who are unrelated but make a
good match may be able to donate a portion of their liver. This type of transplant
is called a living transplant. People who donate a portion of their liver can live
healthy lives with the remaining liver.
An entire liver may be transplanted, or just a section. Because the liver is the only
organ in the body able to regenerate, a transplanted portion of a liver can rebuild
to normal capacity within weeks.
Why is a liver transplant recommended?
A liver transplant is recommended for individuals who have serious liver dysfunction
and will not be able to live without having the liver replaced. The most common liver
disease for which transplants are done is viral hepatitis-induced cirrhosis. Other
diseases may include the following:
Acute hepatic necrosis or fulminant liver failure
Biliary atresia and other congenital disorders
Liver cancers or bile duct cancer
Autoimmune hepatitis, primary biliary cirrhosis, or sclerosing cholangitis
Liver damage from overdose of medicines toxic to the liver, such as acetaminophen
or too much alcohol use in the past
How many individuals in the U.S. need liver transplants?
Visit the United Network for Organ Sharing (UNOS) website for statistics of patients awaiting a liver transplant, and the number of patients
who underwent a transplant this year.
Where do transplanted organs come from?
The majority of livers that are transplanted come from organ donors who have died.
These organ donors are adults or children who have become critically ill (often due
to an accidental injury) and have died as a result of their illness. If the donor
is an adult, he or she may have agreed to be an organ donor before becoming ill. Parents
or spouses can also agree to donate a relative's organs. Donors can come from any
part of the U.S. This type of transplant is called a deceased donor transplant.
An individual receiving a transplant may either get a whole liver, or a segment of
one. If an adult liver is available and is an appropriate match for 2 individuals
on the waiting list, the donor liver can be divided into 2 segments and each part
is transplanted one for the adult and one for a child.
Living family members may also be able to donate a section of their liver. This type
of transplant is called a living-related transplant. Individuals receiving a partial
liver seem to do as well as those receiving a whole liver. Relatives who donate a
portion of their liver can live healthy lives with the segment that remains.
How are transplanted organs allocated?
UNOS is responsible for transplant organ distribution in the U.S. UNOS oversees the
distribution of many different types of transplants, including liver, kidney, pancreas,
heart, lung, and cornea.
UNOS receives data from hospitals and medical centers throughout the country regarding
adults and children who need organ transplants. The medical team is responsible for
sending the data to UNOS, and updating it as your condition changes.
Criteria have been developed to make sure that all people on the waiting list are
judged fairly. They judge the severity of their liver illness using the MELD score
and the associated urgency of receiving a transplant. Once UNOS receives the data
from local hospitals, people waiting for a transplant are placed on a waiting list
and given a "status" code. In adults, this is called a MELD score. The people in most
urgent need of a transplant are placed highest on the status list. They are given
first priority when a donor liver becomes available. The MELD score was updated in
January 2016 and now is calculated using measurements of bilirubin, creatinine, an
international normalized ratio (INR), sodium level, and whether the patient is receiving
dialysis for kidney disease. Certain patients get an upgrade in their MELD score based
on certain diseases, such as hepatocellular cancer.
When a donor organ becomes available, a computer searches all the people on the waiting
list for a liver and sets aside those who are not good matches for the available liver.
A new list is made from the remaining candidates. The person at the top of the specialized
list is considered for the transplant. If he or she is not a good candidate, for whatever
reason, the next person is considered, and so forth. Sometimes, people lower on the
list might be considered before a person at the top because of the size of the donor
organ or the geographic distance between the donor and the recipient. There is now
a regional share for sudden liver failure and a MELD score of over 35 in the United
How is an individual placed on the waiting list for a new liver?
Extensive testing must be done before an individual can be placed on the transplant
list. Testing includes:
Psychological and social evaluation
Diagnostic tests for heart, lung, and other organ conditions
Blood tests. Blood tests are done to gather information that will help determine how urgent it
is that an individual is placed on the transplant list. They also are used to make
sure that the individual receives a donor organ that is a good match. These tests
Liver enzymes. Elevated levels of liver enzymes can alert healthcare providers to liver damage or
injury, since the enzymes leak from the liver into the bloodstream.
Bilirubin. Bilirubin is made by the liver and is excreted in the bile. Elevated levels of bilirubin
often indicate an obstruction of bile flow or a defect in the processing of bile by
Albumin. Below-normal levels of proteins made by the liver are associated with many chronic
Clotting studies, such as an international normalized ratio (INR) formerly known as
the prothrombin time (PT). Tests that measure the time it takes for blood to clot are often used before liver
transplantation. Blood clotting needs vitamin K and proteins made by the liver. Liver
cell damage and bile obstruction can both interfere with proper blood clotting.
Renal function. Creatinine reflects the liver function in critically ill people.
Other blood tests will help improve the chances that the donor organ will not be rejected.
They may include:
Your blood type. Each person has a specific blood type: type A+, A -, B+, B -, AB+, AB -, O+, or O
-. When receiving a transfusion, the blood received must be a compatible type with
an individual's type of blood or an immune reaction will happen. The same immune reaction
will happen if the blood contained within a donor organ enters an individual's body
during a transplant.
Viral studies. These tests determine if the recipient has viruses that may increase the likelihood
of infecting the donor organ. These include hepatitis B virus, hepatitis C virus,
cytomegalovirus (CMV) and Epstein-Barr virus (EBV).
Diagnostic tests may include any of the tests that have been done to evaluate the
extent of the disease, including the following:
Abdominal ultrasound (also called sonography). A diagnostic imaging technique that uses high-frequency sound waves and a computer
to create images of blood vessels, tissues, and organs. Ultrasounds are used to view
internal organs and to assess blood flow through various vessels.
Liver biopsy. A procedure in which tissue samples from the liver are removed (with a needle) from
the body for examination under a microscope.
How long does it take to get a new liver?
There is no definite answer to this question. Sometimes, individuals wait only a few
days or weeks before receiving a donor organ. If no living-related donor is available,
it may take months or years on the waiting list before a suitable donor organ is available.
Unfortunately, some people die, about 20%, before an acceptable donor organ can be
How is a person notified when a liver is available?
Each transplant team has its own specific guidelines regarding waiting on the transplant
list and being notified when a donor organ is available. In most instances, you will
be notified by phone or pager that an organ is available. You will be told to come
to the hospital immediately so you can be prepared for the transplant.
What is rejection?
Rejection is a normal reaction of the body to a foreign object. When a new liver is
placed in a person's body, the body sees the transplanted organ as a threat and tries
to attack it. The immune system makes antibodies to try to kill the new organ, not
realizing that the transplanted liver is beneficial. To allow the organ to successfully
live in a new body, medicines must be given to trick the immune system into accepting
What is done to prevent rejection?
Medicines must be given for the rest of the individual's life to fight rejection and
each transplant team has preferences for different medicines. The antirejection medicines
most commonly used include:
The doses of these medicines may change often, depending on your response. Because
antirejection medicines affect the immune system, individuals who receive a transplant
are at higher risk for infections. A balance must be maintained between preventing
rejection and making you very susceptible to infection. Blood tests to measure the
amount of medicine in the body are done periodically to make sure you do not get too
much or too little of the medicines. White blood cells are also an important indicator
of how much medicine you may need.
This risk of infection is especially great in the first few months after transplant
because higher doses of antirejection medicines are given during this time. You will
most likely need to take medicines to prevent other infections from occurring. Some
of the infections you will be especially susceptible to include oral yeast infection
(thrush), herpes, and respiratory viruses.
What are the signs of rejection?
The following are the most common symptoms of rejection. However, each individual
may experience symptoms differently. Symptoms may include:
A fever of 100.4 F (38.0 C) or higher, or as directed by your healthcare provider
Jaundice. A yellowing of the skin and eyes.
Abdominal swelling or tenderness
The symptoms of rejection may resemble other medical conditions or problems. Talk
with your transplant team right away with any concerns you may have.
What is the long-term outlook after a liver transplant?
Living with a transplant is a lifelong process. Medicines must be taken for the rest
of your life to fight rejection. Other medicines must also be taken to prevent side
effects of the antirejection medicines, such as infection. Frequent visits and contact
with the transplant team are essential.
There is no good answer as to how long an individual can be expected to live after
a liver transplant. Each person and every transplant is different. Results improve
continually as healthcare providers and scientists learn more about how the body deals
with transplanted organs and search for ways to improve the success of transplantation.