Fadia A. Kamal, Ph.D.
Research Assistant Professor of Orthopaedics
Primary Appointment: Department of Orthopaedics
Center Affiliation: Center for Musculoskeletal Research
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Osteoarthritis is a debilitating disease with no disease modifying treatment available. Osteoarthritis is characterized by continuous and progressive cartilage loss leading to joint dysfunction. Chondrocyte, the functional cell of cartilage controls cartilage homeostasis by secreting cartilage matrix components and matrix degrading enzymes. In osteoarthritis, the chondrocyte acquires an aberrant phenotype, it differentiates to become hypertrophic and secretes higher levels of matrix degrading enzymes, ultimately leading to cartilage matrix degradation and cartilage loss. The Kamal laboratory studies cellular pathways that control chondrocyte homeostasis in healthy tissue and the key processes that transform them to pathological cells, which leads to cartilage damage and loss in osteoarthritis. Eventually, our research focuses on discovering new drugs that target these disease pathways, and control chondrocyte behavior to delay or even reverse osteoarthritis disease process.
Le Bleu HK, Kamal FA, Kelly M, Ketz JP, Zuscik MJ, Elbarbary RA (2017). Extraction of high-quality RNA from human articular cartilage. Anal Biochem. 2017 Feb 1;518:134-138. doi: 10.1016/j.ab.2016.11.018. Epub 2016 Nov 29. PMID: 27913164.
Kamal FA, Travers JG, Schafer AE, Ma Q, Devarajan P, Blaxall BC. G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure. J Am Soc Nephrol. 2016 Jun 13. pii: ASN.2015080852. PubMed PMID: 27297948.
Travers JG, Kamal FA, Robbins J, Yutzey KE, Blaxall BC. Cardiac Fibrosis: The Fibroblast Awakens. Circ Res. 2016 Mar 18;118(6):1021-40. doi: 10.1161/CIRCRESAHA.115.306565. Review. PubMed PMID: 26987915; PubMed Central PMCID: PMC4800485.
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. J Am Coll Cardiol. 2014 Jun 17;63(23):2549-57. doi: 10.1016/j.jacc.2014.02.587. Epub 2014 Apr 2. PubMed PMID: 24703913; PubMed Central PMCID: PMC4083020.