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URMC / Medicine / Allergy, Immunology, and Rheumatology Research / Funding / Clinical Trials and Research Studies

 

Clinical Trials and Research Studies

The Clinical Immunology Research Center participates in cutting edge clinical trials of the newest treatments for autoimmune, rheumatic and allergic diseases. In addition to conventional drug studies aimed to improve the efficacy and safety of current therapies, our clinical research center also carries out experimental protocols of particular interest for patients not responding to conventional therapy. In addition, some faculty conduct translational research linking clinical and basic research.

The principal investigators listed below are conducting active clinical trials.

  Dr. Anandarah's Profile

  • A Phase 4, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy & Safety of Apremilast (CC-10004) in Subjects with Early Oligoarticular Psoriatic Arthritis
    Sponsor: Celgene; NCT03747939
    Status: ENROLLING
  • PSA003 - A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Two Doses Of Apremilast (CC-10004) In Subjects With Active Psoriatic Arthritis
    Sponsor: Celgene Corporation; NCT01307423
    Status: CLOSED

 Dr. Anoliks' Profile

  • B Cell Tolerance Mechanisms in Human SLE
    Status: ENROLLING
  • A Double-Blind, Placebo-Controlled Randomized, Multicenter Study to Assess Changes in Omega-3 Index in Erythrocytes and Health Clinical Benefit after 24 weeks of Daily Consumption of AKBM-3031 (Omega-3 Phospholipids from krill), Followed by a 24 Week Open-Label Extension, in Patients with Systemic Lupus Erythematosus (SLE)
    Sponsor: Aker Biomarine Antarctic AS; NCT0362631
    Status: ENROLLING
  • Med/AIR Subject Database and Tissue Repository
    Sponsor: Investigator Initiated
    Status: ENROLLING
  • AMP Collaboration: Cellular Dynamics at the Synovium Bone Interface in Rheumatoid Arthritis
    Sponsor: NIH
    Status: ENROLLING
  • Medimmune Collaboration in Primary Sjogren's Syndrome
    Sponsor: Medimmune; 49798
    Status: ACTIVE BUT NOT ENROLLING
  • Autoimmunity Patient Cohort
    Sponsor: Autoimmunity Cohort; 13564
    Status: ACTIVE BUT NOT ENROLLING
  • B Cell Homeostasis in Common Variable Immunodeficiency
    Sponsor: Investigator Initiated; 31076
    Status: ACTIVE BUT NOT ENROLLING
  • SSLEDerm- A Pilot Phase 2 R, PC, DB, Study to Evaluate the S&E, Tolerability, Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of CC-220 in Subjects with Systemic Lupus Erythematosus
    Sponsor: Celgene Corporation; NCT02185040
    Status: CLOSED
  • ARA06 A Partially Blinded, Randomized, Multi-Center, Phase IV Trial to Evaluate Mechanism of Action of Anti-TNF Agents in Rheumatoid Arthritis
    Sponsor: NIH; NCT00837434
    Status: CLOSED

  Dr. Korman's Profile

  • Scleroderma Registry
    Sponsor: RSRB 71768 (unfunded)
    Status: ENROLLING

  Dr. Looney's Profile

  • A Prospective Registry to Study Presentation, Clinical Course, Treatment Patterns, and Outcomes in Patients with Systemic Lupus Erythematosus
    Sponsor: RSRB 71768 (unfunded)
    Status: ACTIVE BUT NOT ENROLLING
  • Evaluation of Immunocompetency (Gastrointestinal Dysregulation and Systemic Inflammation in Common Variable Immune Deficiency)
    Sponsor: ACAAI; 64705
    Status: ACTIVE BUT NOT ENROLLING
  • Old Order Mennonites: Effect of Lifestyle on Allergic and Autoimmune Diseases: Role of the Gut Microbiome in Preventing Allergic Diseas
    Sponsor: Env HS CTSI
    Status: CLOSED
  • ALE06-An Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients With Stable, Quiescent Systemic Lupus Erythematosus (SLE) in Patients with Stable, Quiescent Systemic Lupus
    Sponsor:  NIH NIAID; NCT01946880
    Status: CLOSED
  • Old Order Mennonites: Effect of Lifestyle on Allergic and Autoimmune Diseases
    Status: CLOSED

  Dr. Palma's Profile

  • A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Phase II Study to Investigate the Safety and Efficacy of Two Different Dose Regimens of IFX-1 as Add-on to Standard of Care in Subjects TH Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)
    Sponsor: InflaRx; NCT03712345
    Status: ENROLLING
  • A Study to Evaluate the Safety and Efficacy of Upadacitnib in Participants with Giant Cell Arteritis (SELECT-GCA)
    Sponsor: Abbvie; NCT03725202
    Status: ENROLLING

  Dr. Ritchlin's Profile

  • DC-STAMP: Regulators of Osteoclastogenesis and Response Marker in PsA
    Sponsor: NIH; NCT03011242
    Status: ENROLLING
  • A Multicenter, Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Bimekizumab in the Treatment of Subjects with Active Psoriatic Arthritis
    Sponsor: UCB; NCT03896581
    Status: ENROLLING
  • Near InfraRed Fluorescence Imaging of Lymphatic Transport Using Indocyanine Green
    Sponsor: NIH; NCT02680067
    Status: ENROLLING
  • Susceptibility Factors for Arthritis in Patients with Psoriasis
    Sponsor: UCB (IPART Registry)
    Status: ENROLLING
  • Predicting Psoriatic Arthritis Onset: Skin Biopsy Use as Prognosticator
    Status: ENROLLING
  • A Study to Evaluate the Long-Term Safety and Efficacy of Bimekizumab in Subjects With Psoriatic Arthritis
    Sponsor: UCB Biopharma; NCT03347110
    Status: ACTIVE BUT NOT ENROLLING
  • Incubator: DC-STAMP and TRAF3: Regulators of Osteoclastogenesis and Biomarkers in Psoriatic Arthritis
    Sponsor: CTSI; NCT02413749
    Status: ACTIVE BUT NOT ENROLLING
  • Serum, Cellular and Imaging Markers of Arthritis in Psoriasis Patients
    Sponsor: RRF; NCT02413801
    Status: ACTIVE BUT NOT ENROLLING
  • Corrona data collection program
    Sponsor: Corrona; NCT02530268
    Status: ACTIVE BUT NOT ENROLLING
  • BIODAM Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis
    Sponsor: CaRE; NCT01476956
    Status: ACTIVE BUT NOT ENROLLING
  • Imaging and Cellular Markers of Arthritis in Psoriasis Patients
    Sponsor:  Amgen
    Status:  CLOSED
  • CORRONA Spondyloarthritis and Psoriatic Arthritis (SpA/PsA) Registry
    Sponsor:  Corrona; NCT02530268
    Status:  CLOSED
  • A Randomized, Placebo-Controlled, Double-blind, Multicenter Study to Assess the Efficacy and Safety of Multiple Doses of BMS-986165 in Subjects with Active Psoriatic Arthritis (PsA)
    Sponsor:  Bristol-Meyers Squibb; NCT03881059
    Status: CLOSED
  • SEAM: A Multicenter Double-Blind, Randomized Controlled Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects With Psoriatic Arthritis
    Sponsor:  Amgen; NCT02376790
    Status: CLOSED
  • AMVISION-2: A Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Efficacy, Safety and Effect on Radiographic Progression of Brodalumab in Subjects With Psoriatic Arthritis
    Sponsor:  Amgen; NCT02029495
    Status: CLOSED
  • AMG827: A Randomized, Double-blinded, Placebo-controlled, Multiple-dose Study With an Open Label Extension to Evaluate the Safety and Efficacy of AMG 827 in Subjects With Psoriatic Arthritis
    Sponsor:  Amgen; NCT02707341
    Status: CLOSED
  • TRAF3 levels in Blood Monocytes in Rheumatoid Arthritis
    Sponsor:  CTSI
    Status: CLOSED

  Dr. Shah's Profile

  • Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE)
    Sponsor: NIH; NCT02633163
    Status: ENROLLING
  • A Study of KZR-616 in Patients With Systemic Lupus Erythematosus With and Without Nephritis
    Sponsor: Kezar Life Sciences; NCT03393013
    Status: ENROLLING
  • Pilot Trial of Ustekinumab for Primary Sjögren’s Syndrome
    Sponsor: Janssen; NCT04093531
    Status: ENROLLING

  Dr. Tabechian's Profile

  • Musculoskeletal Ultrasound
    Sponsor: None; 14883
    Status: ACTIVE BUT NOT ENROLLING