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Clinical Trials

The Clinical Immunology Research Center participates in cutting edge clinical trials of the newest treatments for autoimmune, rheumatic and allergic diseases. In addition to conventional drug studies aimed to improve the efficacy and safety of current therapies, our clinical research center also carries out experimental protocols of particular interest for patients not responding to conventional therapy. The Division currently has numerous active clinical trials in rheumatoid arthritis, psoriatic arthritis, psoriasis, erosive osteoarthritis, Sjogren’s syndrome, lupus as well as with biologics.

Clinical Trial Sponsor
IRB #:
Protocol #:
ClinicalTrials.gov #:
Clinical Trial Title Status PD/PI & Research
Community Members
Investigator Initiated
35516
N/A
Med/AIR Subject Database and Tissue Repository Enrolling Jennifer Anolik, M.D, Ph.D.
NIH
55411
N/A
AMP Collaboration: Cellular Dynamics at the Synovium Bone Interface in Rheumatoid Arthritis Enrolling Jennifer Anolik, M.D, Ph.D.
Amgen
20130207
NCT02376790
SEAM: A Multicenter Double-Blind, Randomized Controlled Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects With Psoriatic Arthritis Enrolling Christopher Ritchlin, M.D., MPH
NIH
54038
N/A
NCT02680067
Near InfraRed Fluorescence Imaging of Lymphatic Transport Using Indocyanine Green Enrolling Christopher Ritchlin, M.D., MPH
ACAAI
64705
N/A
Evaluation of Immunocompetency (Gastrointestinal Dysregulation and Systemic Inflammation in Common Variable Immune Deficiency) Enrolling Maria Slack, M.D.
UCB (IPART Registry)
23525
01-2008
N/A
Susceptibility Factors for Arthritis in Patients with Psoriasis Enrolling Christopher Ritchlin, M.D., MPH
Env HS CTSI
52971
N/A
Old Order Mennonites: Effect of Lifestyle on Allergic and Autoimmune Diseases: Role of the Gut Microbiome in Preventing Allergic Disease Enrolling R. John Looney, M.D.
Medimmune
49798
N/A
Medimmune Collaboration in Primary Sjogren's Syndrome Enrolling Jennifer Anolik, M.D, Ph.D.
N/A
B cell tolerance mechanism
24888
N/A
B cell tolerance mechanisms in human SLE Enrolling Jennifer Anolik, M.D, Ph.D.
N/A
Autoimmunity Cohort
13564
N/A
Autoimmunity Patient Cohort Enrolling Jennifer Anolik, M.D, Ph.D.
Investigator Initiated
31076
N/A
B Cell Homeostasis in Common Variable Immunodeficiency Enrolling Jennifer Anolik, M.D, Ph.D.
None
14883
N/A
Musculoskeletal Ultrasound Enrolling Darren Tabechian, M.D.
Corrona
24243
02-021
NCT02530268
Corrona data collection program Not Enrolling Christopher Ritchlin, M.D., MPH
Corrona
49150
N/A
NCT02530268
CORRONA Spondyloarthritis and Psoriatic Arthritis (SpA/PsA) Registry Not Enrolling Christopher Ritchlin, M.D., MPH
NIH NIAID
48772
ALE06
NCT01946880
ALE06-An Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients With Stable, Quiescent Systemic Lupus Erythematosus (SLE) in Patients with Stable, Quiescent Systemic Lupus Not Enrolling R. John Looney, M.D.
LCTC
27349
N/A
A Prospective Registry to Study Presentation, Clinical Course, Treatment Patterns, and Outcomes in Patients with Systemic Lupus Erythematosus Not Enrolling R. John Looney, M.D.
Celgene Corporation
55329
CC-220-SLE-001
NCT02185040
SLEDerm- A Pilot Phase 2 R, PC, DB, Study to Evaluate the S&E, Tolerability, Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of CC-220 in Subjects with Systemic Lupus Erythematosus Not Enrolling Jennifer Anolik, M.D, Ph.D.
NIH
24715
ARA06
NCT00837434
ARA06 A Partially Blinded, Randomized, Multi-Center, Phase IV Trial to Evaluate Mechanism of Action of Anti-TNF Agents in Rheumatoid Arthritis Data Analysis Jennifer Anolik, M.D, Ph.D.
CTSI
53086
N/A
NCT02413749
Incubator: DC-STAMP and TRAF3: Regulators of Osteoclastogenesis and Biomarkers in Psoriatic Arthritis Not Enrolling Christopher Ritchlin, M.D., MPH
RRF
53131
N/A
NCT02413801
Serum, Cellular and Imaging Markers of Arthritis in Psoriasis Patients Not Enrolling Christopher Ritchlin, M.D., MPH
Amgen
29654
N/A
Imaging and Cellular Markers of Arthritis in Psoriasis Patients Closing Christopher Ritchlin, M.D., MPH
CaRE
39665
N/A
NCT01476956
BIODAM Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis Closing Christopher Ritchlin, M.D., MPH
Fellow Project
45280
N/A
Predicting Psoriatic Arthritis Onset: Skin Biopsy Use as Prognosticator Closing Christopher Ritchlin, M.D., MPH
Celgene Corporation
20101481
CC-10004-PSA-003
NCT01307423
PSA003- A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Two Doses Of Apremilast (CC-10004) In Subjects With Active Psoriatic Arthritis Closed Allen Anandarajah, M.D., MSc
NIH NIAID
39964
ASJ02
NCT01552681
ASJ02-A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial of Baminercept, a Lymphotoxin-beta Receptor Fusion Protein, for the Treatment of Primary Sjögren's Syndrome Closed Andreea Coca, M.D.
Amgen, Inc.
55799
20090406
NCT02029495
AMVISION-2: A Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Efficacy, Safety and Effect on Radiographic Progression of Brodalumab in Subjects With Psoriatic Arthritis Closed Christopher Ritchlin, M.D., MPH
Amgen, Inc.
39346
20101227
NCT02707341
AMG827: A Randomized, Double-blinded, Placebo-controlled, Multiple-dose Study With an Open Label Extension to Evaluate the Safety and Efficacy of AMG 827 in Subjects With Psoriatic Arthritis Closed Christopher Ritchlin, M.D., MPH
None
44568
N/A
Old Order Mennonites: Effect of Lifestyle on Allergic and Autoimmune Diseases
Closed R. John Looney, M.D.
CTSI
47923
N/A
TRAF3 levels in Blood Monocytes in Rheumatoid Arthritis Closed Christopher Ritchlin, M.D., MPH