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Cytopathology

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Contact Information

Division of Cytopathology
University of Rochester Medical Center

601 Elmwood Ave. Box 626
Rochester, NY 14642
Main office: (585) 275-5656
Administrative office: (585) 275-1959

About Us

Cytopathology is a division of the Department of Pathology and Laboratory Medicine at the University of Rochester Medical Center.

We strive for continued excellence and efficiency in patient care through state of the art technology. We value collaboration with colleagues in the healthcare community, and seek to share and educate others on the utility and potential of cytopathology for the study and diagnosis of cancer.

What Makes Us Unique

We bring a personalized, multidisciplinary, practice-based approach founded on the fundamental concepts of cytopathology. We employ a team approach starting from the time the sample is obtained. We strive for an accurate diagnosis, and to decrease ambiguity and uncertainty.

Services

The cytopathology laboratory provides clinical, prognostic and therapeutic diagnostic evaluations for most cancer types and consultative services for physicians. These include pap tests, cytologic evaluations of body fluids and fine needle aspiration (FNA) of a great variety of tumors and body sites.

We assist with and also perform fine needle aspiration biopsies on patients with deep seated and superficial lesions, respectively. These FNA’s can be scheduled by appointment and are performed either in the cytopathology laboratory clinic, at the bedside, on hospital floors, or in outpatient clinics.

We currently provide the following services:

  • Performing, processing and interpreting fine needle aspiration of superficial tumors (palpable or ultrasound-guided).
  • Assistance with rapid on-site evaluations (ROSE) for:
  • Computed tomography guided FNAs (CT-guided FNAs)
  • Endobronchial ultrasound guided FNAs (EBUS-FNAs)
  • Endoscopic ultrasound guided FNAs (EUS-FNAs)
  • Electromagnetic navigation bronchoscopy fine needle aspirations (ENB-FNAs)
  • Triage of cytologic material for various molecular studies including PDL-1, EGFR, EML4-ALK, ROS 1, BRAF, KRAS, etc.
  • Triage of cytologic material for immunostains, microbiology cultures, and flow cytometry studies.

Education

The cytopathology division provides continuous educational activities for in house staff and physicians as well as trainees including medical students, residents, and fellows.

The educational offerings include:

  • Weekly integrated anatomic pathology conference on decision making models that incorporate clinical, laboratory, imaging, gross, cytology, histology and ancillary pathology studies.
  • Weekly didactic cytopathology fellow-resident lectures.
  • Quarterly hands-on workshops for handling aspirated material, smearing, and rapid on site evaluations.
  • On an as-needed basis: cancer prevention related outreach.

Fellowship

The Stanley F. Patten Cytopathology Fellowship is a one-year ACGME-accredited fellowship offering advanced training in diagnostic cytopathology, including application of ancillary techniques such as immunocytochemistry, flow cytometry, molecular diagnostics and electron microscopy to cytologic specimens. Considerable emphasis is placed on correlations between cytopathologic and surgical pathologic diagnoses. Pathologists perform superficial FNAs. The fellow also participates in interdepartmental conferences and in teaching residents and medical students. Individuals interested in applying must have completed a four-year accredited AP/CP Pathology Residency program and be board eligible/certified.

Current openings: 1 (July 2019). Click here for more information.

Our Faculty

Research

Our Cytopathology faculty actively publish new research that supports and enhances our approach to clinical care.

Recent Faculty Publications

2016 Nov
Li W, Molnar SL, Mott M, White E, De Las Casas LE"Superficial CD34-positive fibroblastic tumor: Cytologic features, tissue correlation, ancillary studies, and differential diagnosis of a recently described soft tissue neoplasm." Diagnostic cytopathology. 2016 Nov; 44(11):926-930. Epub 2016 Jul 19.

2016 Sep
Oppenheimer DC, Giampoli E, Montoya S, Patel S, Dogra V. "Sonographic Features of Nodular Hashimoto Thyroiditis." Ultrasound quarterly. 2016 Sep; 32(3):271-6.

2016 Jul 29
Choy B, LaLonde A, Que J, Wu T, Zhou Z. "MCM4 and MCM7, Potential Novel Proliferation Markers, Significantly Correlated with Ki67, Bmi1, and Cyclin E Expression in Esophageal Adenocarcinoma, Squamous Cell Carcinoma, and Precancerous Lesions." Human pathology. 2016 Jul 29; Epub 2016 Jul 29.

2016 May
Molnar SL, Zarka MA, De Las Casas LE"Going beyond "Basaloid neoplasm": Fine needle aspiration cytology of epithelial-myoepithelial carcinoma of the parotid gland." Diagnostic cytopathology. 2016 May; 44(5):422-5. Epub 2016 Jan 22.

2016
Ghatak S, Reveiller M, Toia L, Ivanov AI, Zhou Z, Redmond EM, Godfrey TE, Peters JH. "Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling". J Gastrointest Surg. 2016; 20(3): 500-9.

2016
Rong Lu, Y Zhang, S Wu, Y Xia, Z Zhou, I Tako, H Dong, M Bissonnette, J Sun. "Salmonella protein AvrA activates the STAT3 signaling pathway in colon cancer." Neoplasia. 2016; 18(5): 308-16.

2016
Toumeh A, Sakhi R, Shah S, Arudra SK, De Las Casas LE, Skeel RT. "Ipilimumab-Induced Granulomatous Disease Occurring Simultaneously With Disease Progression in a Patient With Metastatic Melanoma." American journal of therapeutics. 2016 23(4):e1068-71.

2015 Jul 9
Huber AR, Tan D, Sun J, Dean D, Wu T, Zhou Z"High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7." BMC gastroenterology. 2015 Jul 9; 15:80. Epub 2015 Jul 09.

2015 Apr
Li W, Molnar S, Cantley R, Kurtycz DF, De Las Casas LE"Metastatic small cell carcinoma of uterine cervix to the thyroid gland diagnosed by ultrasound guided fine needle aspiration (US-FNA) cytology: a proactive approach." Diagnostic cytopathology. 2015 Apr; 43(4):349-51. Epub 2014 Aug 01.

2015 Mar
Tchantchaleishvili V, Staicu SA, Giampoli EJ, Chen L, Massey HT. "Utilizing right ventricular assist device with extracorporeal membrane oxygenator for management of diffuse alveolar damage after orthotopic heart transplant." Artificial organs. 2015 Mar; 39(3):289-91.

2015 Mar
Hammer A, Oladimeji P, De Las Casas LE, Diakonova M. "Phosphorylation of tyrosine 285 of PAK1 facilitates ?PIX/GIT1 binding and adhesion turnover." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Mar; 29(3):943-59. Epub 2014 Dec 02.

2015 Jan
Jain S, Chaitanya Arudra SK, De Las Casas LE"Cystic nephroma of the kidney." The Journal of urology. 2015 Jan; 193(1):313-4. Epub 2014 Oct 16.

2015
Datar I, Feng J, Qiu X, Lewandowski J, Yeung M, Ren G, Aras S, Al-Mulla F, Cui H, Trumbly R, Arudra SK, De Las Casas LE, de la Serna I, Bitar MS, Yeung KC. "RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13." PloS one. 2015 10(8):e0134494. Epub 2015 Aug 26.

2015
Jiang M; Ku WY; Zhou Z; Dellon ES; Falk GW; Nakagawa H; Wang ML; Liu K; Wang J; Katzka DA; Peters JH; Lan X; Que J. "BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis". J. Clin. Inves. 2015; 125(4): 1557-1568.

2015
Huber AR; Tan D; Sun J; Dean D; Wu T; Zhou Z. "High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7." BMC Gastroenterology. 2015; 15: 80.

2015
Wu S; Zhang YG; Lu R; Xia Y; Zhou D; Petrof EO; Claud EC; Chen D; Chang EB; Carmeliet G; Sun J. "Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis." Gut. 2015; 64(7): 1082-1094

2015
Chuang KH; Whitney-Miller CL; Chu CY; Zhou Z; Dokus MK; Schmit S; Barry CT. "MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs via targeting TET1 invasive human HCC tumors." Hepatology. 2015; 62(2): 466-480.

2015
Costaldi ME; Lall A; Burack R; Zhou ZD. "Using Flow Cytometry for the Diagnosis of Lung Neuroendocrine Carcinoma With Samples From Endobronchial Ultrasound Fine Needle Aspiration and Pleural Fluid." J. Interdiscipl. Histopathol. 2015; 3(1): 3-8.

2015
AK.Martin and Z Zhou. "Endoscopic ultrasound-guided FNA for the Diagnosis of Pancreatic Cysts by Combined Cytopathology and Cystic Content Analysis." World Journal of Gastroenterologic endoscopy. 2015; 7(15).