Pediatrics / Divisions & Centers / Critical Care Division / Research / Current Studies Current Studies ABC-Trial, “Age of Blood Cell Transfusions in Children” An international study examining the impact of the age of blood cells in pediatric critically ill patients.” (PALISI Network) PI: Phillip Spinella; Marissa Tucci; Jacques Lacroix. University of Rochester Site PI: Jill M. Cholette, MD, Co-Investigator: L. Eugene Daugherty, MD. “Genetic Epidemiology of Life Threatening Influenza in Children.” PI: Adrienne Randolph, MD, Children's Hospital Boston. Co-Investigator: Kate Ackerman, MD, Sub-Investigators: L. Eugene Daugherty, MD and Jill M. Cholette, MD. "Iron Treatment for Insomnia in Children with Autism Spectrum Disorders." A multi-site, collaborative trial with University of Colorado. PI: Ann Reynolds, MD. University of Rochester Site PI: Heidi V. Connolly, MD. "Prevention of Central Venous Catheter-Associated Thrombosis in Critically Ill Children: A Multicenter Phase 2b Trial" Yale (Vince Faustino PI). Site PI: Jill M. Cholette, MD. "Enoxaparin Prophylaxis for High Risk Pediatric Cardiac Surgery Patients" PI: Jill Cholette, MD. "Transfusion of Cell Saver Blood for 24 Hours After its Collection: Impact on Infection and Outcomes." PI: Elizabeth Nocera.Senior Investigator: Jill M. Cholette, MD. "Use of Neural Networking to Create Smarter PICU Alarm Parameters." PI: Heather Reyes. Senior Investigator: Jeffrey Rubenstein, MD, MBA. "Cell-Free DNA (cfDNA) as a Marker for Clinical Outcomes After Neonatal Cardiovascular Surgery." PI: Melissa Cullimore. Senior Investigator: Kate Ackerman, MD. "Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE)." PALISI Network. Site PI: Kate Ackerman, MD. "Patient Driven Gene Discovery in Children with Critical Illness." Yale (Saquib Lakhani). Site PI: Kate Ackerman, MD. "Epigenetics of Transition from Fetal to Adult Circulation." PI: Kate Ackerman, MD.