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Lymphoma: Brentuximab vedotin and involved site radiotherapy in newly diagnosed, unfavorable risk Hodgkin lymphoma.

Research Question:
Will treatment with a new drug, brentuximab vedotin (BV), combined with adriamycin, vinblastine, and dacarbazine (AVD) chemotherapy followed by radiation improve the ability to cure more patients with Hodgkin Lymphoma?

Basic Study Information

Purpose:
Early stage, high risk HL has a chance of coming back after standard treatment. The best treatment for early stage, high risk HL is chemotherapy followed by radiation. The chemotherapy is called ABVD and has four drugs approved by the Food and Drug Administration (FDA): doxorubicin, bleomycin, vinblastine, and dacarbazine. This is a pilot phase II study of a new treatment plan for your HL. The treatment consists of a new drug, brentuximab vedotin (BV), combined with adriamycin, vinblastine, and dacarbazine (AVD) chemotherapy followed by radiation. The purpose of this study is to find out whether BV with AVD chemotherapy and radiation is a safe and effective treatment. BV is a type of drug called an antibody drug conjugate. BV has 2 parts; a part that targets cancer cells (the antibody) and a cell killing part (the chemotherapy). The antibody part of BV sticks to a target called CD30. CD30 is an important molecule on HL cancer cells and some normal cells of the immune system. The cell killing part of BV is a chemotherapy called monomethyl auristatin E (MMAE). It can kill cells that the antibody part of BV sticks to.

Location: Cancer Center
Study Web URL:  http://clinicaltrials.gov/ct2/show/NCT01868451?term=Brentuximab+Vedotin+Combined+with+AVD+Chemotherapy+and+30+Gray&rank=1
Study Reference #: ULYM-14035

Lead Researcher (Principal Investigator)

Lead Researcher: Carla Casulo

Study Contact Information

Study Coordinator: Yelena Lerman
Phone: (585) 276-8333
Email: ylerman@URMC.Rochester.edu

Additional Study Details

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