Developmental Impact of NICU Exposures (DINE)Research Question:
Does exposure to phthalate in the neonatal intensive care unit harm cognitive development
of pre-term infants?
Basic Study Information
Purpose:Location: University of Rochester
Entry into the DINE study requires prior enrollment in the Prematurity and Respiratory
Outcomes Program (PROP) or the Impact of Respiratory Virus Infections and Bacterial
Microbiome Shifts/PRISM study. If you have not participated in these studies in the
past you will not be eligible for this trial.
The DINE study will test the hypothesis that potentially avoidable NICU-based exposures
contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates.
This hypothesis is drawn from the documented impact of phthalate exposure on early
development in term-born children, and the acknowledged presence of these toxic chemicals
in the NICU. Third trimester in utero exposure to phthalates have been linked to poorer
childhood performance in cognition, motor function, attention, hyperactivity and social
behavior. Phthalate exposure is also associated with altered onset of puberty and
asthma. The multi-site cohort and approach will clarify the role of NICU-based phthalate
exposure on high-prevalence clinical outcomes.
Lead Researcher (Principal Investigator)
Lead Researcher: Gloria Pryhuber
Study Contact InformationStudy Coordinator: Gloria S Pryhuber, MD
Phone: (718) 839-7009
Additional Study Details
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