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Developmental Impact of NICU Exposures (DINE)

Research Question:
Does exposure to phthalate in the neonatal intensive care unit harm cognitive development of pre-term infants?

Basic Study Information

Entry into the DINE study requires prior enrollment in the Prematurity and Respiratory Outcomes Program (PROP) or the Impact of Respiratory Virus Infections and Bacterial Microbiome Shifts/PRISM study. If you have not participated in these studies in the past you will not be eligible for this trial. The DINE study will test the hypothesis that potentially avoidable NICU-based exposures contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates. This hypothesis is drawn from the documented impact of phthalate exposure on early development in term-born children, and the acknowledged presence of these toxic chemicals in the NICU. Third trimester in utero exposure to phthalates have been linked to poorer childhood performance in cognition, motor function, attention, hyperactivity and social behavior. Phthalate exposure is also associated with altered onset of puberty and asthma. The multi-site cohort and approach will clarify the role of NICU-based phthalate exposure on high-prevalence clinical outcomes.

Location: University of Rochester

Lead Researcher (Principal Investigator)

Lead Researcher:  Gloria Pryhuber

Study Contact Information

Study Coordinator: Gloria S Pryhuber, MD
Phone: (718) 839-7009

Additional Study Details

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