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Lynne Elizabeth Maquat, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-5640

Fax: (585) 271-2683

Research Labs

Faculty Appointments

  • Professor - Department of Biochemistry and Biophysics (SMD) - Primary
  • Professor - Cancer Center
  • J. Lowell Orbison Distinguished Service Alumni Professorship - Department of Dean's Office, SMD (SMD)
  • Director, Center for RNA Biology - Department of Office of VP for Health Sciences (URMC)



Research in my lab focuses on RNA decay pathways. One pathway, called nonsense-mediated mRNA decay (NMD) or mRNA surveillance, surveys all newly synthesized mRNAs during what we call a "pioneer" round of translation. This round of translation involves mRNA that is associated with the cap-binding heterodimer CBP80 and CBP20. It is distinct from the type of translation that supports the bulk of cellular protein synthesis and involves a different cap-binding protein, eukaryotic initiation factor (eIF) 4E. Generally, if translation terminates more than 50-55 nt upstream of an exon-exon junction that is marked by the NMD factors Upf3 or Upf3X, Upf2 and ultimately Upf1, then the mRNA will be subject to NMD. By the time CBP80 and CBP20 have been replaced by eIF4E, the Upf mark has been removed so that mRNA is largely immune to NMD.

Studies in progress will significantly advance our understanding of the mRNP proteins, translation factors and nucleases that trigger NMD. Our results will be useful when designing therapies that aim to abrogate NMD in order to abrogate the severity of nonsense-generated diseases. We are also interested in further characterizing the pioneer translation initiation complex and requirements for its remodeling to the steady-state initiation complex that involves eIF4E. Additionally, we are interested in the cycle of posttranslational modifications that typify at least some of the NMD factors, including phosphorylation of Upf1 that is mediated by the PI 3-kinase-related protein kinase Smg1.

Over the past 15 years, our discovery and subsequent work on the mechanism of Staufen (Stau)-mediated mRNA decay (SMD) has uncovered new roles for cytoplasmic long non-coding RNAs (lncRNAs) and retrotransposon-derived short interspersed elements (SINEs) in post-transcriptional gene regulation. These SINEs include human Alu elements and mouse B1, B2, B4 and ID elements. We have shown that NMD and SMD are competitive pathways in ways that contribute to cellular homeostasis and also differentiation. We continue to define new cellular roles for SINEs as sites for nucleating intermolecular base-pairing between different mRNAs, between mRNAs and lncRNAs, and between different lncRNAs. We are additionally extending our studies of inverted-repeat Alu elements (IRAlus) and how competitive binding among the many nuclear and cytoplasmic double-stranded RNA binding proteins influence nuclear and cytoplasmic IRAlus-containing RNA metabolism.

Most recently, we have discovered a new microRNA decay pathway that is mediated by Tudor-SN. This pathway, which we call TumiD, promotes G1-to-S phase transition by degrading microRNAs that degrade mRNAs encoding proteins that promote this transition. We are currently working on how TumiD is regulated.

Please visit our lab website for more information on our exciting past and ongoing research pursuits as well as opportunities available to join our group.



BA | University of Connecticut

PhD | Univ Wisconsin-Madison


FASEB Excellence in Science Award
Sponsor: Federation of American Societies for Experimental Biology

2017 Vanderbilt Prize in Biomedical Science
Sponsor: Vanderbilt

2017 International RNA Society Lifetime Achievement in Science Award
Sponsor: RNA Society
Location: Prague, Czech Republic

Canada Gairdner International Award
Sponsor: The Gairdner Foundation

William C. Rose Award
Sponsor: American Society of Biochemistry and Molecular Biology

Athena Award
Sponsor: Women's Council of the Rochester Business Alliance

2013 - Present
MERIT Award from the NIH GM

Batsheva de Rothschild Fellow of the Israel Academy of Sciences and Humanities

Presidential Diversity Award
Sponsor: University of Rochester

Elected to the National Academy of Sciences
Sponsor: National Academy of Sciences

RNA Society Lifetime Achievement Award in Service
Sponsor: RNA Society

Elected to the American Academy of Arts and Sciences
Sponsor: American Academy of Arts and Sciences

Elected to the American Association for the Advancement of Science
Sponsor: American Association for the Advancement of Science

Davey Memorial Award for Outstanding Cancer Research
Sponsor: Wilmot Cancer Center, URMC

RPI/RNA Award for most significant paper co-authored by a junior scientist published in RNA
Sponsor: RNA Journal

Exemplary "Woman in Government"
Sponsor: New York State Commissioner of Health

1985 - 1989
American Heart Association Established Investigatorship
Sponsor: American Heart Association

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Title: Compositions and Methods for Inhibiting CBP80 Binding to PGCI Family of Co-Activators
U.S. Serial #:
Filed: Dec 08, 2016
Invented By: RudiFasan, LynneMaquat

Title: Methods and Compositions Related to Staufen 1 Binding Sites Formed By Duplexing ALU Elements
U.S. Serial #: 13/984,709
Filed: Feb 09, 2012
Invented By: ChenguangGong, LynneMaquat


Journal Articles

Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M, Maquat LE. "Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay." Proceedings of the National Academy of Sciences of the United States of America.. 2018 Jan 30; 115(5):968-973. Epub 2018 Jan 16.

Rambout X, Dequiedt F, Maquat LE. "Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing." Chemical reviews.. 2017 Dec 18; Epub 2017 Dec 18.

Popp MW, Maquat LE. "Nonsense-mediated mRNA Decay and Cancer." Current opinion in genetics & development.. 2017 Nov 7; 48:44-50. Epub 2017 Nov 07.