Clostridium difficile Infection (CDI) Surveillance
Purpose
C. difficile is a bacteria that causes diarrhea, and occasionally, severe infection, hospitalization, and death. The purpose of this surveillance in Monroe County is to monitor trends in C. difficile incidence and strain type in order to target prevention efforts.
Goals and Objectives
- Determine the population-based incidence of community- and healthcare-associated CDI among participating EIP sites.
- Characterize C. difficile strains that are responsible for CDI in the population under surveillance with a focus on strains from community-associated cases.
- Describe the epidemiology of community- and healthcare-associated CDI and generate hypotheses for future research activities using EIP CDI surveillance infrastructure.
Activities
The incidence of C. difficile in Monroe County has decreased since 2010, specifically in nursing home- and hospital-onset cases. This may be due in part to local efforts to reduce C. difficile infections in these healthcare settings. A change in the strain type of C. difficile over time may also account for the decreases.
Selected Publications
- Guh AY, Mu Y, Baggs J, Winston LG, Bamberg W, Lyons C, Farley MM, Wilson LE, Holzbauer SM, Phipps EC, Beldavs ZG, Kainer MA, Karlsson M, Gerding DN, Dumyati G. Trends in incidence of long-term-care-facility-onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. Am J Infect Control. 2018 (in press).
- Hunter JC, Mu Y, Dumyati GK, Farley MM, Winston LG, Johnston HL, Meek JI, Perlmutter R, Holzbauer SM, Beldavs ZG, Phipps EC, Dunn JR, Cohen JA, Avillan J, Stone ND, Gerding DN, McDonald LC, Lessa FC. Burden of nursing home-onset Clostridium difficile infection in the United States: estimates of incidence and patient outcomes. Open Forum Infect Dis. 2016;3(1): ofv196.
- Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise M, Clifford McDonald L, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine. 2015 Oct 5; Epub 2015 Oct 05.
- Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, Dunn JR, Farley MM, Holzbauer SM, Meek JI, Phipps EC, Wilson LE, Winston LG, Cohen JA, Limbago BM, Fridkin SK, Gerding DN, McDonald LC. Burden of Clostridium difficile in the United States. The New England journal of medicine. 2015 Feb 26; 372(9):825-34.
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