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Multi-Site Gram-negative Surveillance Initiative (MUGSI)

Purpose

MUGSIGram-negative bacilli commonly cause infections in both health care and community settings. Emergence of resistance of these organisms to several antibiotics, such as carbapenems, makes treatment of these organisms more challenging. Examples of gram-negative bacilli include E. coli and K. pneumoniae. To monitor trends in the incidence of carbapenem resistant Enterobacteriaceae (“CRE”) and Extended-Spectrum β-Lactamases (ESBLs) Enterobacteriaceae, we conduct population-based surveillance among residents of Monroe County, NY, as part of the Centers for Disease Control and Prevention (CDC) Emerging Infections Program MUGSI initiative

Goals and Objectives

  • Determine the extent of CRE, carbapenem-resistant Acinetobacter and ESBLs disease in Monroe County
  • Identify people most at risk for illness from these organisms
  • Measure trends of disease over time

Activities

Working with laboratories in Monroe County, the surveillance team identifies carbapenem resistant organisms, as well as those resistant to third generation cephalosporins. Demographic data and potential risk factors for infection and prior exposure to health care are collected. Selected isolates are sent to the CDC for further study.

Publications

  • Wozniak JE; Band VI; Conley A; Rishishwar L; Burd EM; Satola SW; Hardy D; Tsay R; Farley MM; Jacob JT; Dumyati G; Jordan IK; Weiss DS.  A Nationwide Screen of carbapenem-resistant reveals an isolate with enhanced virulence and clinically undetected colistin-heteroresistance. Antimicrob agents and chemother. 2019;Epub 2019 Feb 25. doi: 10.1128/AAC.00107-19.
  • Bulens SN, Yi SH, Walters MS, Jacob JT, Bower C, Reno J, Wilson L, Vaeth E, Bamberg W, Janelle SJ, Lynfield R, Vagnone PS, Shaw K, Kainer M, Muleta D, Mounsey J, Dumyati G, Concannon C, Beldavs Z, Cassidy PM, Phipps EC, Kenslow N, Hancock EB, Kallen AJ. Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012-2015External. Emerg Infec Dis. 2018 Apr;24(4):727-34. doi: 10.3201/eid2404.171461.
  • Guh, A: Bulens., SN; Mu, Y; Jacob, JT; Reno, J; Scott, J; Wilson, LE, Sc,M; Vaeth, E; Lynfield, R; Shaw, KM; Snippes, PM; Vagnone, MT(ASCP); Bamberg, WM; Janelle, SJ; Dumyati, G; Concannon, C; Beldavs, Z; Cunningham, M; Cassidy, M; Phipps, EC; Kenslow, N; Travis, T; Lonsway, D; Rasheed, JK; Limbago, BM; Kallen, AJ. Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013. Journal of the American Medical Association. 5 October 2015. Article Link