Devin Chandler-Militello, M.S.Email Devin
Differentiation of human glial progenitor cells from iPSCs for amyotrophic lateral
sclerosis to examine changes in gene expression. Working with Dr. Windrem to generate iPSC
and hESC-derived glial progenitor cells for cell therapy.
Steven A. Goldman, M.D., Ph.D.Email Steven
Identify the expression patterns of the major categories of stem and progenitor cells of the adult human brain and to use that information to define the signaling pathways that distinguish one progenitor from another, as well as those that distinguish brain tumor stem and progenitor cells from their normal counterparts.
Tamara Major, Ph.D.Email Tamara
Application of glial progenitor cells derived from human embryonic stem (hES) cells and induced pluripotent stem (iPS) cells for neurodegenerative disease modeling and development of stem cell based therapeutic strategies.
Maiken Nedergaard, M.D., DMScEmail Maiken
The basic biology of glial cells in the CNS and the role of astrocytes in several neurological diseases, including stroke, spinal cord injury, epilepsy, tremor, and ALS. Research is aimed at defining new strategies for the treatment of neurological diseases that target astrocytic dysfunction.
Joana Osorio, M.D.Email Joana
Cell based therapies for treatment of congenital disorders of myelin, particularly Pelizaeus Merzbacher disease and Krabbe disease. Gene editing of human induced pluripotent stem cells from patients with Pelizaeus Merzbacher disease for autologous cell transplantation. Differential characteristics of human and murine NG2+ oligodendrocyte progenitor cells in the grey and white matter. Migration and dispersal of human oligodendrocyte progenitor cells in the rat brain.
Martha Windrem, Ph.D.Email Martha
The use of glial progenitor cells for treating disorders of myelin, in both pediatric and adult animal models of myelin disease. She also studies the biology of human astrocytes and oligodendrocytes in vivo, in chimeric brain models that permit the assessment of human cells in vivo, in rodent models of neurological disease.
Jim Xu, Ph.D.Email Jim
Using in vivo
and in vitro
electrophysiological, multiphoton, oxygen sensor and potassium sensor methods to investigate the physiological functions of astrocytes in the central nervous system.