Faculty ABCDEFGHIJKLMNOPQRSTUVWXYZFacultyDepartment/LabInterestsRobert J. Agate, Ph.D.NeurologyGoldman LabIdentifying and characterizing those molecular pathways that serve to link testosterone-induced angiogenesis and neurogenesis. His work focuses on the adult songbird forebrain, a uniquely powerful model for assessing the molecular mechanisms of induced angiogenesis and neurogenesis in the adult vertebrate brain.Abdellatif Benraiss, Ph.D.NeurologyGoldman LabThe use of gene therapeutic strategies to induce and regulate neurogenesis from endogenous neural stem cells in the adult mammalian brain, with a particular emphasis on developing this as a therapeutic strategy in Huntington's disease.Rashid Deane, B.Sc., Ph.D.NeurosurgeryNedergaard LabThe role of the neurovascular unit (blood-brain barrier, pericytes, astrocytes, microglia and neurons) in controlling the brain’s microenvironment in health and disease. This includes clearance mechanisms of molecules (e.g., tau), from the aging and injured brain, and the impact of toxicants and metals in the development of cognitive decline and diseases, such as Alzheimer’s disease (AD). Understanding how the aging brain distributes and eliminates molecules may lead to novel therapeutic approaches for the diagnosis and prevention of AD, and thus minimize the burden of the pending AD tsunami.Steven A. Goldman, M.D., Ph.D.NeurologyGoldman LabIdentify the expression patterns of the major categories of stem and progenitor cells of the adult human brain and to use that information to define the signaling pathways that distinguish one progenitor from another, as well as those that distinguish brain tumor stem and progenitor cells from their normal counterparts.Nanhong Lou, M.D.NeurosurgeryNedergaard LabThe role of gliosis and glial cell signaling in stroke by using in vivo multiphoton imaging and electrophysiological methods.Maiken Nedergaard, M.D., DMScNeurosurgeryNedergaard LabThe basic biology of glial cells in the CNS and the role of astrocytes in several neurological diseases, including stroke, spinal cord injury, epilepsy, tremor, and ALS. Research is aimed at defining new strategies for the treatment of neurological diseases that target astrocytic dysfunction.Weiguo Peng, M.D.NeurosurgeryNedergaard LabSpinal cord and spinal nerve injury; more specifically the secondary injury after spinal cord trauma and how to improve the recovery of spinal cord injury.Martha Windrem, Ph.D.NeurologyGoldman LabThe use of glial progenitor cells for treating disorders of myelin, in both pediatric and adult animal models of myelin disease. She also studies the biology of human astrocytes and oligodendrocytes in vivo, in chimeric brain models that permit the assessment of human cells in vivo, in rodent models of neurological disease.