Robert J. Agate, Ph.D.
NeurologyIdentifying and characterizing those molecular pathways that serve to link testosterone-induced angiogenesis and neurogenesis. His work focuses on the adult songbird forebrain, a uniquely powerful model for assessing the molecular mechanisms of induced angiogenesis and neurogenesis in the adult vertebrate brain.
Abdellatif Benraiss, Ph.D.
NeurologyThe use of gene therapeutic strategies to induce and regulate neurogenesis from endogenous neural stem cells in the adult mammalian brain, with a particular emphasis on developing this as a therapeutic strategy in Huntington's disease.
Devin Chandler-Militello, M.S.
NeurologyDifferentiation of human glial progenitor cells from iPSCs for amyotrophic lateral
sclerosis to examine changes in gene expression. Working with Dr. Windrem to generate iPSC
and hESC-derived glial progenitor cells for cell therapy.
Rashid Deane, B.Sc., Ph.D.
NeurosurgeryThe role of the neurovascular unit (blood-brain barrier, pericytes, astrocytes, microglia and neurons) in controlling the brain’s microenvironment in health and disease. This includes clearance mechanisms of molecules (e.g., tau), from the aging and injured brain, and the impact of toxicants and metals in the development of cognitive decline and diseases, such as Alzheimer’s disease (AD). Understanding how the aging brain distributes and eliminates molecules may lead to novel therapeutic approaches for the diagnosis and prevention of AD, and thus minimize the burden of the pending AD tsunami.
Fengfei Ding, M.D.
NeurosurgeryEEG recording and behavior tests
Ali Erturk, Ph.D.
NeurosurgeryStudy of neurodegeneration and inflammation in acute brain
injuries using tissue clearing technologies.
Steven A. Goldman, M.D., Ph.D.
NeurologyIdentify the expression patterns of the major categories of stem and progenitor cells of the adult human brain and to use that information to define the signaling pathways that distinguish one progenitor from another, as well as those that distinguish brain tumor stem and progenitor cells from their normal counterparts.
Rashad Hussain, Ph.D.
NeurosurgeryGlymphatic system in health and disease; neuron-glia interactions and signaling mechanisms.
Nanhong Lou, M.D.
NeurosurgeryThe role of gliosis and glial cell signaling in stroke by using in vivo multiphoton imaging and electrophysiological methods.
Yuan Lu, Ph.D.
NeurosurgeryElectrophysiological study of neuro-glia interaction in neurological
diseases including Alzheimer's disease
Iben Lundgaard, Ph.D.
NeurosurgeryThe function of astrocyte-oligodendrocyte gap junctions.
Tamara Major, Ph.D.
NeurologyApplication of glial progenitor cells derived from human embryonic stem (hES) cells and induced pluripotent stem (iPS) cells for neurodegenerative disease modeling and development of stem cell based therapeutic strategies.
Rupal Mehta, M.D.
Pathology & Laboratory MedicineSmall vessel disease and blood-brain barrier disruption in stroke
Erlend Arnulf Nagelhus, M.D., Ph.D.
Maiken Nedergaard, M.D., DMSc
NeurosurgeryThe basic biology of glial cells in the CNS and the role of astrocytes in several neurological diseases, including stroke, spinal cord injury, epilepsy, tremor, and ALS. Research is aimed at defining new strategies for the treatment of neurological diseases that target astrocytic dysfunction.
Joana Osorio, M.D.
NeurologyCell based therapies for treatment of congenital disorders of myelin, particularly Pelizaeus Merzbacher disease and Krabbe disease. Gene editing of human induced pluripotent stem cells from patients with Pelizaeus Merzbacher disease for autologous cell transplantation. Differential characteristics of human and murine NG2+ oligodendrocyte progenitor cells in the grey and white matter. Migration and dispersal of human oligodendrocyte progenitor cells in the rat brain.
Weiguo Peng, M.D.
NeurosurgerySpinal cord and spinal nerve injury; more specifically the secondary injury after spinal cord trauma and how to improve the recovery of spinal cord injury.
Jiandi Wan, Ph.D.
Imaging SciencesRed cell mechanosensing dynamics, tissue engineering and fluid dynamics.
Su Wang, M.D., Ph.D.
NeurologyDifferentiation of human striatal neural progenitor cells into medium spiny neurons, and the additional changes in their gene expression that accompany their expression of mutant Huntington protein. His goal is to identify targets for intervention in Huntington’s Disease. Working together with Dr. Windrem, Dr. Wang also studies the oligodendrocytic differentiation of human glial progenitor cells, as derived from pluripotential stem cells, for the purpose of establishing iPS and ES cell-based sources of oligodendrocyte progenitors for cell therapy.
Martha Windrem, Ph.D.
NeurologyThe use of glial progenitor cells for treating disorders of myelin, in both pediatric and adult animal models of myelin disease. She also studies the biology of human astrocytes and oligodendrocytes in vivo, in chimeric brain models that permit the assessment of human cells in vivo, in rodent models of neurological disease.
Jim Xu, Ph.D.
NeurologyUsing in vivo and in vitro electrophysiological, multiphoton, oxygen sensor and potassium sensor methods to investigate the physiological functions of astrocytes in the central nervous system.